Abstract: A semiconductor power device comprising an insulated gate bipolar transistor, of the type which comprises a semiconductor substrate with a first type of conductivity and an overlying epitaxial layer with a second type of conductivity, opposite from the first, and whose junction to the substrate forms the base/emitter junction of the bipolar transistor, has the junction formed by a layer of semiconductor material with conductivity of the second type but a higher concentration of dopant than that of the epitaxial layer. Furthermore, the device has the epitaxial layer with conductivity of the second type provided with at least two zones at different dopant concentrations, namely a first lower zone being part of the junction and having a higher dopant concentration, and a second upper zone having a lower concentration.

Abstract: A low molecular weight, tertiary amide terminated polyamide may be blended with a liquid hydrocarbon to form a transparent composition having gel consistency. The tertiary amide terminated polyamide may be prepared by reacting “x” equivalents of dicarboxylic acid wherein at least 50% of those equivalents are from polymerized fatty acid, “y” equivalents of diamine such as ethylene diamine, and “z” equivalents of a monofunctional reactant having a secondary amine group as the only reactive functionality. The stoichiometry of the reaction mixture is preferably such that 0.9≦{x/(y+z)}≦1.1 and 0.1≦{z/(y+z)}≦0.7. The gel contains about 5-50% tertiary amide terminated polyamide, with the remainder preferably being pure hydrocarbon. The gels are useful in formulating personal care products and other articles wherein some degree of gel-like or self-supporting consistency is desired.

Abstract: Compounds, compositions and methods are disclosed for treating mitochondria-associated diseases, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have structure (I) below, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Ar and L are as defined herein. The methods of this invention are directed to treating a mitochondria-associated disease by administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

Abstract: A synthesis member preferably comprises two elements: a crown and a stem. The stem includes a tag, such as a transponder, that is used to identify the synthesis member and/or the synthetic history of the synthesis member when used in the automated synthesis of compound libraries containing large numbers (e.g. 1000 or more) compounds. The crown provides the location at which compounds are synthesized. The combination of a crown for use with compound synthesis and stem allows the tracking of individual synthesis members from a library containing thousands of such synthesis members. Because each synthesis member is individually tracked and can be logged into a database and/or process flow control system, the synthesis of several thousand individual compounds in conventional containers, such as round bottom flasks is made possible using only traditional compound synthesis approaches.

Abstract: Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

Abstract: Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

Abstract: A protective structure having a plurality of protection regions extending along closed lines arranged inside each other. Each intermediate protective region is tangent to two different adjacent protective regions, at different areas, so as to form a connection in series with the adjacent protective regions. The protective structure can be of resistive material, such as to form a series of resistors, or it can include doped portions alternately of P- and N-type, such as to form a plurality of anti-series arranged diodes. The structure can be made of polycrystalline silicon extending on the substrate surface, or can be integrated (implanted or diffused) inside the substrate.

Abstract: A pivot bracket for a convertible boat lounge seat and a bracket in combination with a convertible boat lounge seat having connections for attaching to a pivot bracket beneath and spaced inward of the horizontal seat side edges of the horizontal seat, the bracket having a vertical slot, the bow of a back pivotally and slidably connected to the bracket within the slot for movement of the back into a forward facing position, a rearward facing position, and an upward facing lounge position, the bow pivoting in movement in a slot in the horizontal seat spaced inward from the side edge of the horizontal seat, and bow retaining members spaced forward and aft on the bracket to retain the bow in its forward and rearward facing positions.

Abstract: A pulse inverter with variable pulse frequency for producing a sinusoidal alternating current is provided, wherein the pulse frequency variation is dependent on the configuration of the alternating current to be produced, the pulse frequency at the passage-through-zero of the alternating current to be produced is a multiple greater than in the region of the maximum amplitude of the alternating, current and the lowest pulse frequency in the region of the maximum amplitude of the alternating current is at least 100 Hz. In a preferred embodiment, the pulse frequency in the region of the passage-through-zero of the alternating current to be produced is in the range of about 14-18 kHz, and in the region of the maximum amplitudes of the current it is about 500 Hz to 2 kHz. A wind power installation may be provided with a pulse inverter as described above, or alternatively, a plurality of wind power installations provided with pulse inverters as described above are connected in parallel relationship.

Abstract: Targeting molecules for use in delivering biological agents to non-polarized epithelial cells are disclosed. Upon delivery, the biological agent(s) are lethal to the epithelial cell. The targeting molecules may be used, for example, for the eradication of metastatic epithelial cells.

Abstract: The invention provides a single-well, microscale method of determining the specific apoptotic activity of a cell. The method consists of contacting a cell population of about 1×105 cells for a time period of between about 30 minutes and 4 hours with a sufficient volume of medium containing an apoptotic specific diagnostic reagent and a diagnostic accessory reagent so as to cover the cell population, and determining the activity of the apoptotic specific diagnostic reagent. The invention also provides a method of identifying a compound which induces apoptosis. The invention further provides a rapid method of identifying a compound which inhibits apoptosis.

Abstract: Preparations of nucleic acid condensates and compositions containing such condensates are provided. The nucleic acid condensates are in the form of small particles that are stable when subjected to destabilizing conditions such as lyophilizing, freeze-thawing, and prolonged liquid storage. These compositions may be used to deliver nucleic acid to cells.

Abstract: The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.

Abstract: A method of treating parts (34) in a treatment chamber (33) by hot-isostatic pressing with an inert gas as pressure medium and in the presence of a purifying agent (25a) for the inert gas comprises the steps of reducing the pressure in the treatment chamber (33), increasing the pressure again by introducing the inert gas, increasing the temperature in the treatment chamber (33) by activating heating elements (9a), and, after a certain holding time, reducing the pressure and the temperature again. Especially if the purifying agent (25a) is of the same material as the parts (34) being treated, the purifying effect of the purifying agent becomes insufficient. The effect of the purifying agent (25a) is improved according to the invention by bringing the inert gas, at least when being introduced, to circulate such that it is heated, passes through the purifying agent and is thereafter cooled before contacting the parts. The invention also relates to a device for carrying out the method.

Abstract: This invention relates to a herbicidal composition comprising N-phosphonomethylglycine and/or a salt thereof and an alkyldiamine tetraalkoxylate surfactant, a surfactant composition useful in glyphosate compositions and a method for controlling or eradicating unwanted plants or vegetation.

Abstract: The present invention provide methods and an apparatus for performing amplification and other enzymatic reactions on nucleic acid molecules that have been printed onto a solid substrate, such as a silicon wafer or glass slide.

Abstract: The invention relates to a process for preparing free flowing particles covered with a layer of water glass, comprising the steps of: (a) providing a mixture containing particles to be covered, water and 0.1-5% by weight water glass, calculated on the basis of the weight of the particles, the water glass being dissolved in said mixture, and (b) stirring the mixture mechanically, optionally by supplying heat from an external heat source, and permitting the water to evaporate from the mixture until at least so much water is evaporated that said mixture is no longer sticky. Furthermore, the invention relates to a process for preparing an article with a detailed surface.

Abstract: There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, &bgr;-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the &bgr;-sheet mimetic is a thrombin inhibitor.

Abstract: An ester-terminated dimer acid-based polyamide may be blended with a solvent to form a gel. The solvent may be flammable, and a wick may be added to the resulting gel so as to form a candle. Depending on the composition, the candle may be formed into a free standing pillar, or may be better suited to being placed in a container. The solvent may be mineral oil. A solid coating may be placed around the candle, for advantages including to enhance the clarity and/or mechanical stability of the gelled body, and to eliminate the tendency of a gel to have an oily feel and to accept noticeable fingerprints. The ester-terminated dimer acid-based polyamide may also be combined with an active ingredient, such as a fragrance, colorant, insect-repellant, insecticide, bioactive ingredient or the like, to afford a delivery vehicle for the active ingredient.