Abstract: The present invention is drawn to methods and compounds for transcutaneous photodynamic therapy (“PDT”) of a target tissue or compositions in a mammalian subject, which includes administering to the subject a therapeutically effective amount of a photosensitizing agent or a photosensitizing agent delivery system or prodrug, where the photosensitizing agent or photosensitizing agent delivery system or prodrug selectively binds to the target tissue; and irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent or if prodrug, by a prodrug product thereof, where the light is provided by a light source, and where the irradiation is at low fluence rate that results in the activation of the photosensitizing agent or prodrug product.

Abstract: A device for displaying and exchanging a plurality of documents of various shapes and sizes and for organizing the same. The device of the present invention comprises at least two layers of pliable sheet material. If multiple sheets are used, the sheets may be nested together. The sheets may then be inserted into a binder mechanism where the binder mechanism compressibly engages the layers to create a pressure region adjacent thereto. The frictional force between the sheet material and the inserted document retains a document inserted into the pressure region formed between two adjacent layers.