Abstract: This invention relates to compounds of the formula 1
and to pharmaceutically acceptable salts and solvates thereof wherein X1, X2, R2, R15, R16 and R6 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.
Type:
Grant
Filed:
December 10, 1999
Date of Patent:
December 16, 2003
Assignee:
Pfizer Inc.
Inventors:
Wei-Guo Su, Takushi Kaneko, Yong-Jin Wu
Abstract: A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.
Type:
Grant
Filed:
January 19, 1999
Date of Patent:
July 17, 2001
Assignee:
Pfizer Inc
Inventors:
John Anthony Ragan, Teresa Woodall Makowski, David Jon Am Ende, Pamela Jane Clifford, Gregory Randall Young, Alyson Kay Conrad, Shane Allen Eisenbeis, George Joseph Quallich, Douglas John Meldrum Allen