Abstract: The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post-traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be effected by the antagonism of the CRF-1 receptor.
Type:
Grant
Filed:
January 29, 2004
Date of Patent:
May 1, 2007
Assignee:
Bristol-Myers Squibb Company
Inventors:
Vivekananda M. Vrudhula, Dmitry Zuev, Bireshwar Dasgupta
Abstract: A method for the treatment of depression in a human being, the method comprising administering to the human being an antidepressant effective amount of a compound of the following formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R and R.sup.1 are independently hydrogen or fluorine.
Type:
Grant
Filed:
May 19, 1995
Date of Patent:
July 15, 1997
Assignee:
Glaxo Wellcome Inc.
Inventors:
Nariman Bomanshaw Mehta, Grady Evan Boswell, James Leroy Kelley