Abstract: Expression of an endogenous gene is activated or increased following integration into a cell, by non-homologous or illegitimate recombination, of (1) an enhancer sequence that activates expression of the gene and (2) a sequence that encodes an amplifiable marker. The invention also provides methods for the identification, activation, isolation, and/or expression of genes undiscoverable by current methods since no target sequence is necessary for integration. The invention also provides cells containing the enhancer and amplifiable marker sequence and expressing increased amounts of a desired gene. The invention also provides methods for the isolation of nucleic acid molecules (particularly cDNA molecules) encoding a variety of proteins, including transmembrane proteins, and for the isolation of cells expressing such proteins.

Abstract: A houseplant maintenance device having a base, a water reservoir, one or more wick elements, and wick holder is disclosed. The wick element draws liquid nutrients from the reservoir and makes it available to the plant growing medium, the wick element is capable of being positioned, relative to the water level in the reservoir, to adjust the liquid nutrient delivery rate, both pre-planting and post-planting. Additionally, the wick element can be chemically bonded to provide means to deliver nutrient cations to a potted plant from solid nutrients that are otherwise not readily soluble in water.

Abstract: A method of controlling microbial fouling is provided. The method controls microbial fouling using hypobromous acid, HOBr, formed by the reaction between an aqueous solution of alkali or alkaline earth metal hypochlorite and a bromide ion source. The method is characterized in that the alkali or alkaline earth metal hypochlorite or/and the bromide ion source is/are stabilized by the addition of a stabilizer before the hypobromous acid is formed by the reaction there between.

Abstract: The present invention provides a polyester heat-shrinkable tube for coating electrolytic condenser molded from a resin composition comprising a) 80 to 99 wt % of a copolymerized polyester resin with an intrinsic viscosity of 0.65 to 1.0 dl/g, which comprises 1 to 15 mol % of polyethylene naphthalate and 85 to 90 mol % of polyethylene terephthalate, and b) 1 to 20 wt % of polybutylene terephthalate resin. The polyester heat-shrinkable tube of the present invention has superior heat resistance, strength and coating-adhesion property, so that no cracks may occur in dry-heat treatment after the coating and contraction step, and also that the tube can be tightly adhered to the condenser.

Abstract: Disclosed is a dielectric ceramic composition suitable for use in planar or multilayer type electronic parts containing inner conductors, for the fabrication of which simultaneously sintering base materials and conductors is required.

Abstract: Expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene. The invention also provides methods for the identification, activation, isolation, and/or expression of genes undiscoverable by current methods since no target sequence is necessary for integration. The invention also provides methods for the isolation of nucleic acid molecules (particularly cDNA molecules) encoding a variety of proteins, including transmembrane proteins, and for the isolation of cells expressing such transmembrane proteins which may be heterologous transmembrane proteins. Thus, by the present invention, endogenous genes, including those associated with human disease and development, may be activated and isolated without prior knowledge of the sequence, structure, function, or expression profile of the genes.

Abstract: The present invention relates to a reversible child resistant cap and a closure system having two positions, the first being a child resistant position and the other being a non-child resistant position. The cap is characterized in that it has a closure plane, a circumferential outer skirt for engaging a container, and a circumferential resilient depending inner member.

Abstract: The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment of the invention, expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene. In another embodiment, the expression of the endogenous gene may be further increased by co-integration of one or more amplifiable markers, and selecting for increased copies of the one or more amplifiable markers located on the integrated vector. In another embodiment, the invention is directed to activation of endogenous genes by non-targeted integration of specialized activation vectors, which are provided by the invention, into the genome of a host cell.

Abstract: The present invention provides a new of sulfasalazine as a potent agent for the treatment of neuronal death.

Abstract: This invention relates to a solar control film that blocks the sunlight, when applied to various windows of automobiles, buildings or exhibition places and that prevent any second accident caused by broken glasses at an accident. From the solar control film, a surface protective layer, a plastic film substrate, a hologram-engraved layer, a metal deposition layer, a pressure sensitive adhesive layer and a release film are laminated in due order. The solar control film of this. Hence the above-described solar film has a basic function such as an excellent blocking rate of visible and infrared rays, while demonstrating an additional antifog action and an elegant look due to the hologram effect.

Abstract: The polyester composition for films includes, based on 100 parts by weight of a polyester resin, 0.01 to 5 parts by weight of aluminum silicate particles containing aluminum and silica as principal components and an alkali metal. To provide polyester films suitable for magnetic recording media, the polymer composition contains surface- modified aluminum silicate particles and two additional particles distinct in particle diameter. The polyester films thus obtained have excellent abrasion resistance and scratch resistance.

Abstract: Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapuetics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and nuerodegenerative disease. As cancer therapuetics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.

Abstract: The centralized collection of geographically distributed data is accomplished using a system which takes advantage of an interactive programming language, such as Java® and existing wide area networks, such as the Internet including the world wide web (4), to collect high quality data in an information center (10). The information center being connected to remote sites (1) through the wide area network. One or more levels of validation of the data prior to storage in a database is provided for.

Abstract: The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhibitors which are useful as anticoagulants.

Abstract: A process for forming a multilayer coating film on automotive bodies which comprises applying a clear coating for top coating, by the wet-on-wet technique, onto a base coating containing a color pigment and/or a luster pigment as applied to a coated automotive panel and then heating the coat layers for curing, said base coating comprising, as resin constituents, a product obtained by grafting a silicate compound (A) onto a hydroxyl-containing acrylic resin or polyester resin and a melamine type curing agent.

Abstract: Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding to the GLP-1 receptor and/or prevent activation of the receptor by bound GLP-1. The invention further relates to a method of inhibiting the binding of GLP-1 to the GLP-1 receptor and a method of inhibiting the activation of the GLP-1 receptor. Intermediate compounds useful for making non-peptide GLP-1 receptor antagonists are also described.

Abstract: A tray set composed of a first tray and a second tray, wherein the first tray having a plurality of depressed portions in which sushi toppings can be placed and which each has a shape having a depth so as to fill it with the sushi topping and a portion of a lump of rice seasoned with vinegar. The first tray is provided with a plurality of holes on the bottom so as for liquid dropped or oozed out from the toppings to be discharged therethrough. The second tray is arranged such that it can be laid under the first tray and the liquid discharged from the first tray can be received by a depressed face, and a plurality of projections are formed continually and integrally with the depressed face and the plurality of the projections are disposed so as to be engageable with the holes of the first tray and to project through the holes inside the first tray, when the second tray is laid under the first tray. The projections assist in separating the sushi from the tray.

Abstract: Compounds with heterocyclic-hydroxyimino-fluorene nuclei that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin-dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: The present invention relates to a reversible child resistant cap and a closure system having two positions, the first being a child resistant position and the other being a non-child resistant position. The cap is characterized in that it has a closure plane, a circumferential outer skirt for engaging a container, and a circumferential resilient depending inner member.