Patents Represented by Attorney, Agent or Law Firm Shelby J. Walker
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Patent number: 7125973Abstract: Methods and vectors are described for expressing recombinant proteins on the surface of host cells. These processes and compositions provide the basis for strategies to produce a fusion protein, comprising a membrane anchor that allows extracellular attachment of the fusion protein in a type II orientation.Type: GrantFiled: October 24, 2003Date of Patent: October 24, 2006Assignee: ZymoGenetics, Inc.Inventor: Si Lok
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Patent number: 7122350Abstract: The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from an E. coli expression system.Type: GrantFiled: February 9, 2005Date of Patent: October 17, 2006Assignee: ZymoGenetics, Inc.Inventors: Chung Chan, Tracey A. Pownder
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Patent number: 7122352Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.Type: GrantFiled: February 27, 2004Date of Patent: October 17, 2006Assignee: ZymoGenetics, Inc.Inventors: Darrell C. Conklin, Betty A. Haldeman
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Patent number: 7122632Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.Type: GrantFiled: December 22, 2000Date of Patent: October 17, 2006Assignee: ZymoGenetics, Inc.Inventors: Donald C. Foster, Wenfeng Xu, Karen L. Madden, James D. Kelly, Cindy A. Sprecher, Cameron S. Brandt, Mark W. Rixon, Scott R. Presnell, Brian A. Fox
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Patent number: 7122186Abstract: The present invention relates to a new member of the serine protease family, Ztryp3. Members of this family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts.Type: GrantFiled: July 25, 2005Date of Patent: October 17, 2006Assignee: ZymoGenetics, Inc.Inventor: Darrell C. Conklin
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Patent number: 7119175Abstract: A mammalian cytokine-like polypeptide, called Zcyto10, polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.Type: GrantFiled: December 29, 2003Date of Patent: October 10, 2006Assignee: ZymoGenetics, Inc.Inventors: Darrell C. Conklin, Betty A. Haldeman, Angelika Grossmann
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Patent number: 7119191Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto 10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto 10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.Type: GrantFiled: February 27, 2004Date of Patent: October 10, 2006Assignee: ZymoGenetics, Inc.Inventors: Darrell C. Conklin, Betty A. Haldeman
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Patent number: 7115714Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.Type: GrantFiled: April 15, 2003Date of Patent: October 3, 2006Assignee: ZymoGenetics, Inc.Inventors: Darrell C. Conklin, Betty A. Haldeman
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Patent number: 7074575Abstract: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.Type: GrantFiled: April 8, 2003Date of Patent: July 11, 2006Assignee: ZymoGenetics, Inc.Inventors: Yasmin A. Chandrasekher, Patricia A. McKernan
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Patent number: 7049126Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Ztryp3 is a new member of the serine protease family.Type: GrantFiled: September 17, 2002Date of Patent: May 23, 2006Assignee: ZymoGenetics, Inc.Inventor: Darrell C. Conklin
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Patent number: 6775622Abstract: The present invention provides a solution to the needs described above through a system and method for efficiently detecting near identities in large DNA databases. The system and method disclosed herein make use of an algorithm used to construct and maintain unique DNA databases wherein the unique database contains no two DNA sequences such that one is nearly identical to a region of the other. The system and method are applicable to problems such as an all against all comparison of all the DNA sequences in a large DNA database, clustering and assembling ESTs into the cDNAs that generated the ESTs, mapping assembled ESTs onto genomic sequence, mapping cDNAs onto genomic sequences and locating alternately spliced cDNAs.Type: GrantFiled: January 30, 2001Date of Patent: August 10, 2004Assignee: ZymoGenetics, Inc.Inventor: James L. Holloway
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Patent number: 6737509Abstract: The present invention provides compositions for stimulating an increase in islet proliferation and &bgr;-cell mass using an insulin homolog polypeptide. The present invention also includes methods for treating diabetes by stimulating islet proliferation and &bgr;-cell mass increases and affecting insulin levels.Type: GrantFiled: March 3, 2000Date of Patent: May 18, 2004Assignee: ZymoGenetics, Inc.Inventors: Stephen R. Jaspers, Katherine H. Sprugel, Hong Ping Ren, Jacqueline M. Humes, Ross C. Hoffman, Darrell C. Conklin
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Patent number: 6709659Abstract: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.Type: GrantFiled: July 17, 2000Date of Patent: March 23, 2004Assignee: ZymoGenetics, Inc.Inventors: Si Lok, Darrell C. Conklin, Catherine E. Lofton-Day, Stephen R. Jaspers, Michael R. Stamm
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Patent number: 6686168Abstract: Methods and vectors are described for expressing recombinant proteins on the surface of host cells. These processes and compositions provide the basis for strategies to produce a fusion protein, comprising a membrane anchor that allows extracellular attachment of the fusion protein in a type II orientation.Type: GrantFiled: November 1, 2000Date of Patent: February 3, 2004Assignee: ZymoGenetics, Inc.Inventor: Si Lok
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Patent number: 6686448Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.Type: GrantFiled: May 21, 2001Date of Patent: February 3, 2004Assignee: ZymoGenetics, Inc.Inventors: Si Lok, Choon J. Kho, Anna C. Jelmberg, Robyn L. Adams, Theodore E. Whitmore, Theresa M. Farrah
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Patent number: 6333312Abstract: The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.Type: GrantFiled: October 13, 1998Date of Patent: December 25, 2001Assignee: Curis, Inc.Inventors: Thangavel Kuberasampath, Charles M. Cohen, Herrmann Oppermann, Engin Ozkaynak, David C. Rueger, John E. Smart, Roy H. L. Pang
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Patent number: 6326142Abstract: A method is described by which the association between an oligonucleotide labeled by attachment of a fluorophore and another macromolecule such as a protein or nucleic acid may be determined quantitatively in solution accurately and with high sensitivity. In the performance of this method the polarization of fluorescence of an extrinsic fluorescence probe that is covalently coupled to the oligonucleotide is determined. Changes in fluorescence polarization are related directly to the degree of association between the labeled oligonucleotide and another macromolecule and may be used to quantify the association. Because of its high sensitivity and accuracy, this method may be used to make reliable quantitative measurements of very small amounts of complexes formed between labeled oligonucleotides and proteins, nucleic acids or other macromolecules. The method also allows the accurate calculation of important biochemical parameters such as dissociation constants.Type: GrantFiled: February 18, 1998Date of Patent: December 4, 2001Assignee: PanVera CorporatedInventor: Catherine A. Royer