Patents Represented by Attorney, Agent or Law Firm Sheldon M. McGee
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Patent number: 6818642Abstract: Benzylaminopyrimidine compounds of a certain general formula I, in which the substituents and symbols are as defined in the description, are suitable for controlling Helicobacter bacteria.Type: GrantFiled: March 23, 2004Date of Patent: November 16, 2004Assignee: Altana Pharma AGInventor: Gerhard Grundler
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Patent number: 6818651Abstract: 3,4-Dihydroisoquinoline and isoquinoline compounds of formula I, in which Ar represents a phenyl raidcal of the formulae IIa, IIb or IIc are novel effective PDE7 inhibitors.Type: GrantFiled: August 21, 2003Date of Patent: November 16, 2004Assignee: Altana Pharma AGInventors: Steffen Weinbrenner, Beate Schmidt, Gerhard Grundler, Josef Stadlwieser, Armin Hatzelmann, Geert Jan Sterk
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Patent number: 6815557Abstract: Compounds of formula (I), in which M, A1, A2, K1 and K2 have the meanings as indicated in the description are novel active tryptase inhibitors.Type: GrantFiled: September 9, 2002Date of Patent: November 9, 2004Assignee: Altana Pharma AGInventor: Thomas Martin
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Patent number: 6812349Abstract: The invention relates to compounds of formula (2) in which R1, R2, R3 and R4 have the meanings indicated in the description, their preparation and their further reaction to give compounds of formula (1), in which A1, A2 and R4 have the meanings indicated in the description. The compounds of the formula (1) are valuable intermediates for the preparation of medicaments.Type: GrantFiled: September 23, 2003Date of Patent: November 2, 2004Assignee: Altana Pharma AGInventors: Wolf-Rüdiger Ulrich, Christian Scheufler, Thomas Fuchss, Jörg Senn-Bilfinger
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Patent number: 6780881Abstract: Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium hydroxide and/or sodium carbonate are disclosed. The preparations have advantageous properties when reconstituted for injection.Type: GrantFiled: July 15, 2002Date of Patent: August 24, 2004Assignee: Altana Pharma AGInventors: Rudolf Linder, Rango Dietrich
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Patent number: 6767901Abstract: The present invention provides a pharmaceutical composition for application to the mucosa to be used in drug therapy comprising a water-insoluble and/or water-low soluble substance, ciclesonide, and an aqueous medium, and having an osmotic pressure of less than 290 mOsm. This composition is superior over conventional pharmaceutical compositions for application to the mucosa, due to efficient and high ciclesonide retentivity and permeability to the submucosa or the blood at the mucosa.Type: GrantFiled: July 15, 2002Date of Patent: July 27, 2004Assignee: Altana Pharma AGInventors: Atsuhiro Nagano, Yoshihisa Nishibe, Kazuya Takanashi
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Patent number: 6756371Abstract: The compounds of formula (I) in which R1, R2, A, B and Ar have the meanings as given in the description are novel effective PDe4 inhibitorsType: GrantFiled: April 12, 2002Date of Patent: June 29, 2004Assignee: Altana Pharma AGInventor: Geert Jan Sterk
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Patent number: 6696461Abstract: Compounds of formula (I) in which the substituents as defined in the description are useful for preventing and treating gastrointestinal disorders.Type: GrantFiled: October 4, 2002Date of Patent: February 24, 2004Assignee: Altana Pharma AGInventors: Jörg Senn-Bilfinger, Wilm Buhr, Reinhard Huber, Ernst Sturm
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Patent number: 6676674Abstract: A gastric band of a belt type is presented for attaching around a circumference of a patient's stomach, so as to define the diameter of the stomach opening. The band comprises outer and inner surfaces, wherein the inner surface engages the stomach, and at least the outer surface is formed by an elongated member substantially non-extendable along a longitudinal axis thereof. A through-going opening is made in the elongated member and is located so as to define an end portion of the band having a predetermined length. An opposite end portion of the band is shaped so as to be insertable into the through-going opening for adjusting a desired inner diameter of the band in its closed operating position and fastening the opposite end portion to the outer surface of the band.Type: GrantFiled: March 16, 2000Date of Patent: January 13, 2004Inventor: Moshe Dudai
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Patent number: 6673786Abstract: A compound of formula I in which M, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, B5, B6, K1, and K2 are defined herein and are novel effective tryptase-inhibitors.Type: GrantFiled: May 3, 2002Date of Patent: January 6, 2004Assignee: Altana Pharma AGInventor: Wolf-Rüdiger Ulrich
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Patent number: 6630584Abstract: More than 90% of mutations found in the p53 protein produce a conformational change in p53 which results in the exposure of an epitope, which is otherwise hidden in the hydrophobic core of the molecule. A single chain antibody (scFv) which specifically recognizes this common mutant epitope in mutant p53 but not in wild type p53 is disclosed. Also described are a DNA molecule encoding the scFv, pharmaceutical compositions comprising the antibody and methods of treatment using the pharmaceutical compositions.Type: GrantFiled: March 16, 2000Date of Patent: October 7, 2003Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Beka Solomon, Gerald Cohen, Dimitri Govorko
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Patent number: 6604460Abstract: A stencil printing machine and a control method is provided wherein first and second printing drums 25 and 26 are rotatably supported in close proximity to an outer periphery of a press drum 27 at positions spaced by a given angle, wherein outer circumferential peripheral walls of the first and second printing drums 25 and 26 carry stencil clamping bases 28, respectively, and inner press rollers 33 are located inside the printing drums 25 malid 26, respectively. During printing operation, the printing drums 25 and 26 are rotated with a rotational phase angle of 180 degrees relative to the press drum and, at termination of printing operation, the printing drums 25 and 26 are stopped at respective stationary rest positions which are out of ink stain zones of respective printing drums.Type: GrantFiled: May 2, 2001Date of Patent: August 12, 2003Assignee: Riso Kagaku CorporationInventor: Hiroshi Watanabe
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Patent number: 6591520Abstract: Centrifugal thrower-crusher device for arid matter and other materials having a revolvable inertia wheel (1) and mallets (2) diametrally matched on at least one face of the wheel inside a housing (3) with a front opening (8) at the side in which the mallets (2) are housed in a peripheral channel (17), while in the periphery another opening is defined (9), through which the materials leave thrown selectively in a centrifugal projection.Type: GrantFiled: October 24, 2001Date of Patent: July 15, 2003Inventors: Jose Manuel Abascal Rubio, Pedro Abascal Rubio, Javier Abascal Rubio, Ignacio Abascal Rubio, Jose Fermin Garralda Arizcun
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Patent number: 6569475Abstract: Disclosed are a method for culturing mushroom mycelia using grains, a culture product, and use of the culture product. Edible or medicinal mushroom mycelia are inoculated and cultured in solid media made of grains. Induction of the cultured mushroom mycelia to undergo autolysis produces autolysates rich in antitumorigenic and other medicinally useful materials. The squeezing of the autolysates produces a liquid filtrate, leaving a paste. The filtrate is concentrated for use in foods or medicines. The paste is processed into a nutrient-rich gruel or other foods.Type: GrantFiled: October 5, 2001Date of Patent: May 27, 2003Assignees: C.A. Biotech Co., Ltd.Inventors: Jae-Mahn Song, Se-Youn Han, Yun-Sun Na
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Patent number: 6544250Abstract: The present invention relates to a device for blinding the administration of nonsolid pharmaceutical presentations. The device is in particular an opaque container which has at least two attachments, one of which is intended for connection to a dispenser for the pharmaceutical presentation, and the other of which is intended for connection to an applicator, the inside of said container having means for holding back the pharmaceutical presentation.Type: GrantFiled: April 26, 2001Date of Patent: April 8, 2003Assignee: Altana Pharma AGInventor: Peter Schaffer
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Patent number: 6503246Abstract: An intralesional method for treating a hypertrophic scar or keloid using a cryoprobe. The method comprises: (a) inserting the cryoprobe into the hypertrophic scar or keloid so that the cryoprobe is positioned within the hypertrophic scar or keloid; and (b) introducing a cryogen into the cryoprobe thereby freezing the hypertrophic scar or keloid. The cryoprobe has a sealed distal end comprising a cutting tip. Also disclosed is a cryoprobe comprising an elongated, uninsulated housing having a sealed distal end and a proximal end. The housing comprises therein a cryogen inlet tube. The cryoprobe further comprises a cutting tip at the distal end of the housing and a cryogen vent adjacent to the proximal end and in fluid communication with the interior of the housing.Type: GrantFiled: July 5, 2000Date of Patent: January 7, 2003Assignees: Mor Research Applications Ltd., Cleanetica Ltd.Inventors: Yaron Har-Shai, Micha Amar
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Patent number: 6491890Abstract: The invention concerns a method for continuous long term dosing of CO2 in biologically used media, comprising the steps below: i) expelling an aqueous acid solution from a storage container by means of a chemical reaction which generates gas pressure, ii) dripping the acid solution into a solid and/or liquid carbonate or hydrogen carbonate composition, and iii) supply of the corresponding CO2 to the medium which is used biologically, as well as a set and a reequipment set for carrying out this method.Type: GrantFiled: April 27, 2000Date of Patent: December 10, 2002Inventor: Klaus Söchting