Abstract: The invention provides a biological method of producing isoprenoids.

Abstract: The invention provides a biological method of producing isoprenoids.

Abstract: Disclosed are TALL-1 and TALL-1 receptor protein homologues (agonists and antagonists) designed based on the three-dimensional structure of sTALL-1, eBCMA and eBAFF-R; agonist homologues of APRIL; methods of using wild-type APRIL to inhibit the activity of TALL-1; compositions comprising such homologues, nucleic acid molecules encoding such homologues, and therapeutic methods of using such compounds and compositions. Also disclosed are crystalline complexes of sTALL-1 and sTALL-1 in complex with either BCMA or BAFF-R; models of three-dimensional structures of such crystalline complexes and related structures, methods of drug design using any portion of such structures; methods of design and/or identification of regulatory peptides derived from the such structures; compounds identified by drug design using such structures; and the use of such compounds in therapeutic compositions and methods.

Abstract: A wheel assembly includes a first hub assembly sealingly engageable with a first axial opening in one side of a tire. A second hub assembly is sealingly engageable with a second axial opening on the other side of the tire. The hub assemblies define between them a fluid tight volume within the tire. The wheel further includes a valve having an inlet port in fluid communication with the tire, a valve seat, and at least one annular valve member resiliently biased into unidirectional sealing engagement with the seat. Application of external pressure through the inlet port causes at least a portion of the valve member to resiliently deflect away from the valve seat to thereby open the valve and permit fluid communication with the fluid tight volume.

Abstract: The invention provides isolated and at least partially-purified dicamba-degrading enzymes, isolated DNA molecules coding for dicamba-degrading enzymes, DNA constructs coding for dicamba-degrading enzymes, transgenic host cells comprising DNA coding for dicamba-degrading enzymes, and transgenic plants and plant parts comprising one or more cells comprising DNA coding for dicamba-degrading enzymes. Expression of the dicamba-degrading enzymes results in the production of dicamba-degrading organisms, including dicamba-tolerant plants. The invention further provides a method of controlling weeds in a field containing the transgenic dicamba-tolerant plants of the invention and a method of decontaminating a material containing dicamba comprising applying an effective amount of a transgenic microorganism or dicamba-degrading enzyme(s) of the invention to the material.

Abstract: A communication system and method is provided for handling emergency situations wherein complex public safety radio systems can be used to directly communicate with normally incompatible radio systems used by organizations such as schools, hospital, and other facilities. The system includes a radio communication bridge that is selectively activated by emergency personnel to contact selected organizations. The bridge is activated via a TCP/IP command sent from an organization having activation privileges to the selected communication endpoints. Computer software or firmware installed at various communication endpoints, emergency responder locations, and at an emergency call center is used to facilitate functionality of the system to include emergency notifications, dissemination of information associated with a particular emergency, and the status of the system to include activation and deactivation of the radio bridge.

Abstract: An insulated and refrigerated beverage transport line provides enhanced temperature control of one or more beverages conveyed through the transport line. A plurality of coolant lines carrying a re-circulated coolant makes contact with the one or more product lines. One or more empty lines, referred to as packers, may be placed between the coolant lines and the product lines to provide a dimensionally stable and tight group of lines that are bundled together. An external insulation is provided over the bundle of lines to further enhance insulation for the beverage being transported through the product lines. At least one dedicated coolant return line may be placed remote from the other lines. The dedicated coolant return line carries the highest temperature coolant found in a beverage transport system. Independent and separate insulation of this dedicated coolant return line prevents inadvertent heat transfer to the one or more product lines.

Abstract: A liquid/solid separator system mounted on a mobile cart and connected to a process tank for reducing the rate at which fluids are consumed in manufacturing processes. The system may include automation and also may include a shear-stepped screen including tilted wire wedge wires arranged at varying cant angles. The system may include a fine screen basket received in a settling box.

Abstract: An insulative label is provided for a beverage container to reduce heat transfer, particularly heat transfer by conduction from a consumer's hand to the beverage container. The label comprises a dual-ply construction, with a grid pattern placed between the layered materials. Preferably, the label comprises a film base layer secured to the container, the grid pattern comprising an ink and varnish mixture printed over the film base layer, and a laminate top layer secured to the film base layer. Air is trapped in the gaps or spaces between the protrusions created by the grid pattern, and the trapped air insulates the container. The label has a very thin profile, thereby not perceptibly changing the appearance of the label or the container.

Abstract: The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.

Abstract: The present invention provides methods for identifying and/or enriching fetal cells from maternal blood, using as fetal cell markers the antibodies that the mother produces against paternally inherited fetal antigens. The fetal cell-maternal antibody complexes are identified and isolated using labelled agents that bind to the maternal antibodies. The present invention also provides fetal cells, isolated by use of said maternal antibodies, as a source of fetal DNA for prenatal genetic diagnosis of the fetus.

Abstract: A method of keeping an alcoholic beverage in an open topped vessel cool, said beverage comprising a water content and a dissolved gas content, and said method comprising forming ice in the beverage in the open-topped vessel said ice having a cooling effect on the beverage, said ice being formed in the beverage from water of said water content.

Abstract: Shrink-wrap packaging is provided with at least one reinforced integral handle. Each handle is formed by an opening formed in the shrink-wrap material, and a reinforced area that surrounds the opening. Preferably two handles are located at opposite ends or sides of the package. The reinforced areas include an additional layer of the shrink-wrap film, or may include other material such as other types of thermoplastics, paper/fiber composites, or combinations thereof. Shading may be applied to the reinforced areas in order that a consumer can more easily recognize the openings in the shrink-wrap as designated handles. Other embodiments include handles formed by use of a paperbound element in combination with openings in the shrink-wrap material, and webbing secured to a plurality of the containers along with a handle loop integral with the webbing that is orientated to extend through the opening in the shrink wrap material.

Abstract: This invention relates to improved methods of inducing an immune response for the prevention or treatment of HIV-1 infection by using a nucleic acid vaccine in conjunction with a recombinant viral vaccine, e.g., a poxvirus vaccine, to potentiate and broaden the immune response. The present invention further provides a particularly effective vaccine regimen comprising a DNA vaccine used in combination with a poxvirus virus, especially NYVAC or ALVAC.

Abstract: An air-filter device for a motor vehicle, having a casing and a filtering body separating the clean and dirty compartment, and also having a supporting body for the filtering body and a compression body designed to co-operate mechanically with the supporting body, these bodies being mounted in the manner of sliding drawers in an intermediate mounting compartment; the contact surfaces in mutual sliding bearing of the support and compression bodies are inclined in such a way that the forced stress position leading to a compression of the seal of the filtering body is achieved by displacement of the compression body in the direction of extraction and in that the control device, bringing about this displacement, stresses the supporting body and/or the casing in order to achieve the displacement of the compression body in a forced stress position, at least at the end of displacement.

Abstract: A vehicle lift device and method are provided wherein the lift device has upper and lower platforms that may receive vehicles for parking or storage. The lower platform may be selectively raised or lowered between two levels of a parking structure. The upper platform is mounted on telescoping supports. When the car lift device is raised to place the lower platform at the upper level of the parking structure, the telescoping posts retract allowing the upper platform to lower, thereby providing clearance between the upper platform and a ceiling of the parking structure. The posts retract by the weight of the upper platform, and no hydraulic assist is required. When the lift device is lowered to place the lower platform at the lower level of the parking structure, the upper platform engages the floor of the upper level of the parking structure and thereby covers the opening in the floor. The telescoping posts then extend as the lower platform travels to its lowered position at the lower level.

Abstract: A method and apparatus are provided for the controlled application of ultrasonic energy for conditioning of mixtures of gas and liquids by evolving and/or agglomerating gas bubbles existing with or in a liquid or for coalescing droplets of liquid dispersed in another liquid. The invention in preferred embodiments thereof comprises a coalescing apparatus for increasing the droplet size of a mixture formed as a liquid dispersed in another liquid, and a de-gassing apparatus arranged to evolve and/or agglomerate gaseous bubbles in a gas/liquid mixture. In the apparatuses, ultrasonic transducers are used to impart vibrational energy to the mixtures.