Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: When one time reference distribution node is referenced to another time reference distribution node through a repeater, the same delays are put into signals transmitted from the repeater that are in signals received by the repeater. This is accomplished by introducing variable storage buffers into the paths of signals transmitted from the repeater, and by providing for their control. Since the same delays are added to signals transmitted to a node that are in the signals received from that node, the difference in signal transit times in the two directions of transmission on a duplex transmission path is minimized. Accordingly, the transit time in both directions of transmission between any pair of nodes, which are communicating through the repeater, is essentially the same, and high accuracy is maintained for time reference distribution among the nodes of an electronic network.

Abstract: A method for isolating a non toxic, high molecular weight polysaccharide igen from the crude slime of a Pseudomonas aeruginosa culture, and a method for inducing immunity in a host to said live organisms is described. The slime is initially prepared for the isolation procedure by separating the bacterial cells from the slime and dissolving the slime in a phosphate buffer solution. Dissolved contaminating nucleic acids are then precipitated and separated from solution. A lipid A portion of the contaminating lipopolysaccharide constituent is then removed and precipitated by acetic acid hydrolysis, and the remaining lipids present are extracted with chloroform. Nearly all of the residual nucleic acids are then removed by digestion with nucleases, and the remaining protein extracted with phenol. The aqueous and phenol layers are then separated, and the aqueous layer applied to a gel filter to isolate the antigen by column chromatography. The antigen appears in the void volume.

Abstract: A physiologic facsimile image of a biological target without multipath comination is obtained by first producing, for each one of a plurality of sample locations which are spaced so as to define a two-dimensional array, a time delay spectrum wherein the frequency of each spectral ordinate represents the instantaneous differential propagation delay between a first microwave signal which has been propagated through the target and a second microwave signal which initially corresponds to the first microwave signal, and which has been propagated through means having a predetermined propagation delay, and measuring the amplitude of the spectral ordinate corresponding to the direct ray path of propagation through the target, so as to obtain a set of data. The set of data is then digitized and converted from time domain to frequency domain.

Abstract: The use of narcotic antagonists (e.g., naloxone) in shock therapy is disced.

Abstract: A physiologic facsimile image of a biological target is obtained by: scang the target by transmitting a microwave signal through the target and measuring at least one of the amplitude and phase components of the complex microwave power transmission coefficient at each one of a plurality of sample locations which are spaced so as to define a two-dimensional array and such that a set of digital data for each of the measured components is obtained, and for at least one of the sets of data; sorting the set of data into column order; magnifying data derived from the sorting step so as to enhance the resolution of the image; mapping data derived from the magnifying step into further data using a predetermined mapping function so as to enhance the contrast between selected portions of the image; and obtaining the set of control signals by filtering data derived from the mapping step using a band pass function which rejects spatial frequencies below a predetermined first frequency and/or rejects spatial frequencies a

Abstract: A rapid and accurate method for calibrating an instrument for measuring the reflection coefficient and complex permittivity of unknown dielectric materials in a lumped capacitance method for an automatic network analyzer is described. The method includes the discovery that the capacitance of the instrument filled with air can be calculated by measuring only the reflection coefficients of the instrument filled with air and filled with a standard liquid of known permittivity, without the necessity of calculating the capacitance value from the dimensions of the instrument. The complex permittivity of the unknown can then be calculated by measuring the reflection coefficient of the instrument filled with the unknown dielectric. Complex permittivity measurements are useful in, for example, evaluating the time course of dielectric dispersions in biological samples.

Abstract: A method for electromagnetic analysis of cellular or cell ghost physiology and pharmacology without disrupting the physcial integrity of the cell membrane is described. The method utilizes the technique of multifrequency automatic network analysis and signal processing to derive complex permittivities from the error corrected complex reflection coefficient of cell containing samples at each measured frequency. Complex permittivity at each frequency is then related to the dispersion in dielectric conductivity (a term which includes ohmic and non-ohmic losses) thereby measuring the ion permeability barrier and transport functions of the cell membrane and ion distribution inside of and outside of the cell membrane. The method measures the complex reflection coefficient of a capacitive termination containing a cellular sample as high frequencies are applied.

Abstract: A portable target raising and lowering device system is disclosed which is used for gunnery practice. A remotely controlled motor arrangement moves the target from a lowered position to a raised position, and back again. The device system is capable of operation with specialized targets used for either simulated visible laser training guns or live fire. When live fire is used, a target is employed which does not engage a motor-actuated control arm on the return stroke and a magnet is used to hold the target in the raised position until the target is hit and knocked to the down position. If the target is not hit, a solenoid is used to move the target to the down position.

Abstract: A video highlight attenuation processor is disclosed which comprises an it circuit from which first and second signals corresponding to an input signal are derived, a peak detecting and inverting circuit which detects and inverts peak portions of the first signal to produce an intermediate signal, and a mixer which combines the intermediate signal and the second signal such that an output signal is produced which corresponds to the input signal with the D.C. level of the peak portions attenuated.

Abstract: An apparatus and method for the recovery of small plastic tissue sections described. A container having parallel sides is rotatably supported on its ends. Slides are placed in the container at an angle. The container is filled with a liquid and the histologic specimens are floated on the liquid within the receptacle. The container is then tilted so that the slides are horizontal and the sections are floating over the slides. A valve allows release of the liquid from the container into a trough. When the water level falls just below the level of the slides the valve is closed and the slides are removed for further processing.

Abstract: Preparation of the crystalline complex [Na{NH.sub.3.BH.sub.2 -(CN)}.sub.6 from NMe.sub.3.BH.sub.2 I and NaCN in liquid NH.sub.3 is disclosed. Structural details of this novel octahedral complex are obtained by single-crystal X-ray analysis. Evidence indicates that the complex is a valuable antiarthritic agent, since it completely inhibits bacteria-induced chronic arthritis in rats with no evidence of toxic effects. The complex also possesses analgesic and anti-inflammatory activity.

Abstract: The subject 8-amino-6-methoxy lepidine derivatives have the formula: ##STR1## wherein, R represents an --alkylene (tertiary) amine, --alkylene-NH.sub.2, (N-alkylsubstituted piperadyl amino)-alkylene-, --alkylene-(tertiary) amine or --alkylene-N-heterocyclic; R.sub.1, represents an alkoxy, alkyl, halogenated alkyl, alkenyl, aryloxy, halogen or hydrogen radical; R.sub.2 represents an alkyl, halogenated alkyl or aryloxy; n represents integers 3, 4, 5, 6 or 7; and pharmaceutically acceptable salts thereof wherein the salt forming acid or acid-hydrate is organic or inorganic. These derivatives afford improvement in means for the chemotherapy of leishmaniasis. Presence of a basic sidechain attachment at position 8- provides means for enhancement of the effectiveness of such compounds, which may be administered parenterally or orally to infected animals.

Abstract: Subject triaryl benzyl phosphonium salts afford new means for the treatment f African trypanosomiasis. Such compounds may be administered safely to infected animals either parenterally or orally.