Abstract: The invention relates to defined peptides and the quantitative determination thereof in body fluids of patients suffering from progredient chronic dementia, in relation to the concentration of said peptides in a control group. The inventive peptides come from a protein precursor having the corresponding gene, are processed in a specific manner, and are optionally post-translationally modified, especially phosphorylized. An increase in the concentrations of these peptides or the corresponding non-processed protein indicates progredient chronic dementia. Progredient chronic dementia is detected by identifying the peptides and/or the protein individually or in combinations. The invention also relates to the use of said peptides for controlling the course of progredient chronic dementia and for the prognosis of progredient chronic dementia, especially for complementing or replacing mini-mental scores, and for developing therapeutic agents to combat progredient chronic dementia such as Alzheimer's disease.
Type:
Grant
Filed:
May 8, 2002
Date of Patent:
April 10, 2007
Assignee:
Biovision AG
Inventors:
Norbert Lamping, Hans-Dieter Zucht, Harmut Selle, Michael Jürgens, Gabriele Heine, Rüdiger Hess
Abstract: A retractable applicator system for retractably securing a lip care product to a garment of a user. The retractable applicator system includes an applicator for containing and applying a lip care substance to the lips of the user. A retractor assembly is coupled to the applicator for removably mounting the applicator to a garment of the user in a manner that permits selective movement of the applicator away from the body of the user.
Abstract: This optical arm applicable to robots is comprised of: some bent tubular parts (1, 6, 16, 18), a straight tubular length (21) and an outlet part (23), coupled together with the possibility of rotation; also including some means (7) to secure the optical arm to a robot (5). The bent tubular part (1) is mounted with the possibility of rotation on the outlet (2) of a laser generator (3) secured to the third arm (4) of the robot (5). Parts (1, 6, 16 and 18) have a window (28), in each bend, equipped with some inner lugs (28) which a mirror (29) is pressed on to by means of some springs (33) foreseen with a removable part (32).