Abstract: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
January 2, 2001
Assignee:
Connaught Laboratories Limited
Inventors:
Michel H. Klein, Run-Pan Du, Mary E. Ewasyshyn
Abstract: An implement handle is made for use by a crippled person, utilizing a cap adapted to receive an end of the implement and an initially flexible bag attached to the cap. Material in the plastic state is inserted into the bag, the material becoming rigid with the passage of time, and the bag is placed into the hand of the crippled person while the material is becoming rigid. The crippled person maintain a substantially constant grip on the bag during this process, whereupon the rigidified handle conforms itself to his particular grip.