Abstract: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
Type:
Grant
Filed:
June 13, 2007
Date of Patent:
March 2, 2010
Assignee:
Sanofi Pasteur Limited
Inventors:
Michel H. Klein, Run-Pan Du, Mary E. Ewasyshyn