Abstract: A method predicting of cancer chemoresponse of the population of cancer cells to the one or more chemotherapeutic agents. Our ability to treat patients with advanced stage and recurrent endometrial cancer is hampered by an incomplete understanding of the molecular basis of disease development and response to therapy. A novel class of gene products called microRNA (miRNA) has recently been implicated in the etiology of several different human cancers. Altered levels of expression of specific miRNAs may contribute to cancer development in a variety of cancers such as endometrial cancer and may also influence response to cytotoxic chemotherapy or other cancer treatments. Evidence is provided that differential expression of miRNAs contributes to endometrial carcinogenesis and further associates with sensitivity of endometrial cancer cells to various chemotherapeutic agents including cisplatin and doxorubicin chemotherapy.

Abstract: A method of facilitating payments to service providers such as medical practitioners wherein a virtual payment card issued by a card processor is processed by the service provider responsive to a first payment. The merchant identification number of the service provider and its associated acquirer are captured by the card processor. Subsequent payments to the service provider are made directly from the card processor to the acquirer and an authorization confirmation of the direct payment and an explanation of benefits are sent to the service provider which no longer needs to run virtual payment cards through its card processing system.

Abstract: A multi-port circuit and corresponding method for simultaneous shaping of sub-nanosecond pulses (MCS3P). The MCS3P includes a coupled-line coupler, a Schottky detector diode, and circuitry for compressing the rising and falling edges of a waveform. The MCS3P simultaneously produces square wave, Gaussian, and monocycle waveforms by differentiating a sinusoidal source. The method includes the steps of compressing the rising edge of a sinusoidal source waveform, differentiating the resulting waveform to form a square waveform and a Gaussian waveform, filtering out the positive going Gaussian to produce a negative going Gaussian, differentiating the Gaussian waveform to form a monocycle waveform, and compressing the falling edge of the square waveform to produce a square wave form with both edges compressed.

Abstract: Provided is a critical point method used to determine the points of a real-time stream of location data, such as Global Positioning System (GPS) data, that should be retained based on their importance in reconstructing the travel path of a mobile device. The method may run on a mobile device or on a server. When run on a mobile device, the method reduces the amount of data transferred between mediums by only transferring points that are critical to reconstructing the path of travel of the mobile device. This reduction saves power used in the wireless transmission and reception of the non-critical data and the bandwidth used while transmitting non-critical data. The method may be run every time a new position is calculated. When a new position is determined to be a critical point, the point is transmitted. If the new position is not a critical point, then the point is discarded.

Abstract: An inertial masking assembly that allows multiple thin film structures to be deposited on a single substrate by rotation of a shadow mask relative to the substrate. The assembly rotates the position of the shadow mask by the conservation of momentum. The substrate is seated on means for rotating the substrate in a confined orbit within the mask. Abruptly changing the angular velocity of the mask causes the mask to rotate under the substrate, which is mediated by a combination of friction and the substrate's inertia.

Abstract: A bistable MEMS platform. The bistable MEMS platform converts a rotational input into an ortho-planar displacement and can maintain either it's up or down position without an input force due to bi-stability. The bistable MEMS platform generally includes three components. The first component is a pair of quadrantal bistable mechanisms (QBM). The second is a compliant version of a micro helico-kinematic platform (HKP) that serves to coordinate the motion of the QBM. The third component is an aerial platform, which is a variation of a scissor lift mechanism that attaches to the output of the QBM and amplifies the out-of-plane displacement.

Abstract: An apparatus that enables real time measurement of the spatial profile, circularity, centroid, astigmatism and M2 values of a laser beam generated by a high power laser beam. The apparatus employs the optics used in a process application, including a focus lens and cover glass. An attenuation module includes a pair of high reflecting mirror plates disposed in parallel, spaced apart relation to one another at a common angle of incidence to the laser beam. A beam dump is positioned out of a path of travel of the laser beam and in receiving relation to light reflected by the first and second mirrors. A camera detects spots of light that pass through the first and second mirrors. A high power attenuator formed by a highly reflective mirror pair is positioned between the source and the attenuation module. A second embodiment includes a single mirror plate having highly reflective surfaces.

Abstract: The present invention is a method for electromanipulation of chemical species in vivo relative to a target tissue utilizing a nonconductive, conformable array base adapted to be placed coincident to the target tissue, a plurality of electrode elements projecting from the array base towards the target tissue, the electrode elements addressable individually, an electrical source coupled to the plurality of electrodes, a control means interposed between the electrical source and the plurality of electrode elements and in circuit communication therein, the control means adapted to establish an electrical potential between at least two electrodes, and a delivery means adapted to introduce chemical species to the target tissue.

Abstract: A method of receiving Multiple Input Multiple Output—Orthogonal Frequency Division Multiple Accessing (MIMO-OFDMA) signals using a single receiver rather than multiple receivers and performing measurements specific to various parts of MIMO-OFDMA systems using all measurable parameters of MIMO-OFDMA systems is disclosed. In addition, a method of receiving and completing impairment estimation of WiMAX MIMO signals using a single receiver according to the IEEE 802.16 standards is provided.

Abstract: Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereoselective nature of the palladium catalyzed transformations.

Abstract: Methods and compositions useful for preventing the disruption of thiol (sulfur) signaling which affects degenerative/age related disease and other disease states related to thiol redox signaling, such as S-glutathiolation. The compositions are capable of increasing the DNA transcription of Gamma-Glutamyl-cysteine synthase which is the rate limiting enzyme for the production of the thiol regulating enzyme Glutathione. The acid-stable compositions disclosed herein contain esterfied and free form cafestol and kahweol, and may be formed using ground roasted or unroasted coffee beans. The beans in combination with water are exposed to cavatonic energy sonic or mechanical. C&K typically increase cholesterol and damage the liver. The compositions disclosed are absorbed before or after the distal portion of the small intestines, eliminating liver toxicity and increases in cholesterol.

Abstract: A solid state lighting device includes a first group of semiconductor light emitting devices that produces a yellowish white light, a second group of semiconductor light emitting devices that includes at least one light emitting device that produces a reddish orange light, and a third group of semiconductor light emitting devices that includes at least one wavelength down-converted white light device. A combination of the second and third groups produces a sub-mixture of reddish warm white light. A combination of the first, second and third groups produces a mixture of warm white light with a correlated color temperature between 2700k to 3500K and a color rendering index higher than 85.

Abstract: A ring electrode design that produces a uniform mass sensitivity distribution across a TSM device is presented. A new technique and apparatus to measure this mass sensitivity distribution is also presented. Novel electrode geometries on thickness shear mode (TSM) quartz resonators achieve radial uniformity of mass sensitivity, how receptive the device is to mass loadings, and high frequency stability across the active sensing area of the sensor device. The device allows for absolute mass measurement down to the nanogram level. Fabricated devices utilizing model predictions were tested using this apparatus, and good agreement between theory and experiment is found.

Abstract: Genomic analysis of ovarian cancers demonstrated a regional chromosomal increase in expression and gene duplication. TGF-? stimulation indicated a link between SnoN RNA and TGF-?. In TIOSE, SnoN protein levels were reduced 15 min post TGF-?-stimulation, likely by proteosome-mediated degradation. SnoN inhibition decreased cell growth between 20 and 50% concurrent with increased p21 levels. Stable expression of SnoN led to growth arrest through induction of senescence. Collectively, these results implicate SnoN levels in multiple roles during ovarian carcinogenesis: promoting cellular proliferation in ovarian cancer cells and as a positive mediator of cell cycle arrest and senescence in non-transformed ovarian epithelial cells.

Abstract: In accordance with the present invention, novel methods for adaptive receiver design and related parameter estimation techniques for efficient and non-coherent reception of ultrawideband signals are presented. Efficient estimation of maximum excess delay of the channel for enabling many useful adaptation techniques is additionally provided. Also, noise power estimation which significantly improves the performance of the receivers is presented.

Abstract: The present invention comprises new materials, material structures, and processes of fabrication of such that may be used in technologies involving the conversion of light to electricity and/or heat to electricity, and in optoelectronics technologies. The present invention provide for the fabrication of a clathrate compound comprising a type II clathrate lattice with atoms of silicon and germanium as a main framework forming lattice spacings within the framework, wherein the clathrate lattice follows the general formula Si136?yGey, where y indicates the number of Ge atoms present in the main framework and 136?y indicates the number of Si atoms present in the main framework, and wherein y>0.

Abstract: The optical device projects a three dimensional image into free space. A series of minors are aligned thereby allowing an image reflect three times between the two minors. The distance between the mirrors may be altered, changing the size and orientation of the final image. In other arrangements, the minors are aligned to permit an image to reflect five times. The minors of the device are concave, may be spherical or parabolic, and may be fragments of a spherical or parabolic minor.

Abstract: An apparatus and method for simultaneously applying a compressive and a reciprocating force to underlying adipose cells from a location external to a patient's skin to rupture or otherwise remove the adipose cells within a subcutaneous tissue region. The adipose cells are ruptured through the mechanical application of compression and shearing forces. The patient's body then re-absorbs and expels the ruptured cells. This eliminates the need for invasive liposuction and the trauma associated with invasive liposuction. Various mechanical devices may be employed to impart the compressive and shearing forces.

Abstract: A document navigation tool that automatically navigates a document based on previous input from the user. The document navigation tool is utilized each time a page loads. The method recognizes user behavior on pages using patterns, which are based on four criterion: location, frequency, consistency, and scope. If the user has visited the page previously and has established a pattern, the method automatically focuses on the portion of the page indicated by the pattern, e.g. the location on a web page of the link clicked by the user in the user's last three visits to the page. If the user has not visited the page previously, the method logs the events that occur during this visit to the page.

Abstract: A frame includes a pair of parallel arms that are transversely spaced apart from one another. A first brace interconnects the parallel arms at their respective leading ends and a second brace interconnects the parallel arms at their respective mid-lengths. A table has a first end hingedly connected to the second brace. A first and second plurality of teeth is provided along an extent of the first and second arms, respectively. First and second support struts hingedly interconnect the table to preselected teeth when the table is in a first angular position relative to the frame. First and second book supports are slideably mounted on the table and lockable into any selected position. The parallel arms are releasably attached to the armrests of a conventional wheelchair. The support struts are disengaged from the teeth to enable folding the table into a horizontal storage position where it overlies the frame.