Abstract: A process for the preparation of active receptor and receptor complex fractions from cell lines expressing cell surface receptors which comprises applying ultrasonication to provide said expression to the cells in an aqueous (detergent free or substantially detergent free) composition.

Abstract: Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

Abstract: Immune stimulatory amounts of hematopoietic colony stimulating factors are administered to patients with inflammatory bowel disease. The factors include G-CSF and GM-CSF. These factors induce and maintain remission of the disease and its manifestations, whether within the intestine or without.

Abstract: A method for producing a rigid, closed-cell polyurethane foam having a free-rise density of from about 1.3 lbs/ft.3 to about 4 lbs/ft.3 and exhibiting a shrinkage of less than 10%, comprises mixing together an isocyanate, at least one alkyl alkanoate blowing agent and at least one polyol having a hydroxyl number of from about 150 to about 800 and being selected from the group consisting of polyalkoxylated amines, polyalkoxylated ethers, and polyester polyols, to form a reaction mixture that is curable to produce such foam.

Abstract: The present specification discloses methods of determining risk of developing Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS) in an individual infected with dengue virus (DV). The methods comprise determining, in a fluid or tissue sample of an individual, the presence, absence or quantity of dengue virus protein NS1, and determining, in a fluid or tissue sample of the individual, presence, absence or quantity of SC5b-9 complement complex. The methods can further comprise comparing the levels of NS1 protein and SC5b-9 complement complex with a database comprising epidemiological data correlating levels of NS1 protein and SC5b-9 complement complex with probability of developing DHF/DSS in a population.

Abstract: A series of N-substituted 9-azabicyclo[3.3.1]nonan-3?-yl phenylcarbamate analogs are disclosed, as well as methods of their preparation. Their affinities for sigma (?1 and ?2) receptors are described. Two new compounds, N-(9-(4-aminobutyl)-9-azabicyclo[3.3.1]nonan-3?-yl)-N?-(2-methoxy-5-methylphenyl)carbamate and N-(9-(6-aminohexyl)-9-azabicyclo[3.3.1]nonan-3?-yl)-N?-(2-methoxy-5-methylphenyl)carbamate, are shown to have a high affinity and selectivity for ?2 versus ?1 receptors. Among the disclosed compounds are biotinylated and fluorescent analogs. These compounds can serve as probes to the ?2 receptor. In addition, some disclosed compounds can induce apoptotic cell death by both caspase-dependent and caspase-independent mechanisms, and are effective for treatment of tumors. The compounds can be used as chemotherapeutics or chemosensitizers in the treatment of a wide variety of solid tumors.

Abstract: Novel benzamide compounds of Formula (I), Formula (II), and Formula (III), salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (II) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.

Abstract: This invention provides a novel electronically tunable active duplexer for wireless transceiver applications. It relates to an active duplexer with full-duplex operation, permitting simultaneous transmission and reception of signals at same or different frequencies. It incorporates varactors, instead of fixed or mechanically adjustable capacitors, in phase shifting networks enabling one to electronically tune, with ease and precision, the frequency at which isolation is desired, over a band in both transmit and receive modes of operations. It can be implemented as a Monolithic Microwave Integrated Circuit (MMIC).

Abstract: Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors (KPI) that possess potent anticoagulant activity are provided. The fusions, abbreviated ANV:KPI, utilize ANV having high affinity for phosphatidyl-L-serine with various KPI's to target serine proteases in membrane-associated coagulation complexes in the blood coagulation cascade. ANV:KPIs are potentially useful antithrombotic drugs permitting localized passivation of thrombogenic vessel walls and associated thrombi.

Abstract: A family of reflectin proteins is identified herein that is deposited in flat, structural platelets in reflective tissues of the squid Euprymna scolopes. These proteins are encoded by at least six genes in three subfamilies and have no reported homologues outside of squids. Reflectins possess 5 repeating domains, that are remarkably conserved among members of the family. The proteins have a highly unusual composition with four relatively rare residues (tyrosine, methionine, arginine, and tryptophan) comprising ˜57% of a reflectin, and several common residues (alanine, isoleucine, leucine, and lysine) occurring in none of the family members. These protein-based reflectors in squids provide a striking example of nanofabrication in animal systems.

Abstract: The instant invention relates to the soybean variety designated SE72581. Provided by the invention are the seeds, plants and derivatives of the soybean variety SE72581. Also provided by the invention are tissue cultures of the soybean variety SE72581 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety SE72581 with itself or another soybean variety and plants produced by such methods.

Abstract: The instant invention relates to the soybean variety designated SD82997. Provided by the invention are the seeds, plants and derivatives of the soybean variety SD82997. Also provided by the invention are tissue cultures of the soybean variety SD82997 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety SD82997 with itself or another soybean variety and plants produced by such methods.

Abstract: The instant invention relates to the soybean variety designated 0037393. Provided by the invention are the seeds, plants and derivatives of the soybean variety 0037393. Also provided by the invention are tissue cultures of the soybean variety 0037393 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 0037393 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated 0384279. Provided by the invention are the seeds, plants and derivatives of the soybean variety 0384279. Also provided by the invention are tissue cultures of the soybean variety 0384279 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 0384279 with itself or another soybean variety and plants produced by such methods.

Abstract: The inventive label sensing device includes a label detector within a housing. The label detector includes a bearing assembly serving as a piston, the bearing assembly having a roller bearing for riding over label material. The roller bearing moves the bearing assembly vertically as the roller bearing rides over the label material based on the height differential of the label and the label substrate. The bearing assembly is in contact with the first end of a lever arm at a pivot point located on the bearing assembly. As the bearing assembly moves up and down, the first end of the lever arm moves responsive to movement of the pivot, generating an amplified signal in the second end of the lever arm, proportional to movement of the roller bearing. Provided at a location adjacent to the second end of the lever arm is a proximity sensor for detecting the movement of the second end of the lever arm within a soft switching region.

Abstract: A novelty noisemaker and hand sign comprising a hand-shaped foam rubber body portion having a front panel and a rear panel. The invention has a vinyl plastic or other like material covering which is affixed continuously to said front panel. The rear panel contains five digit slits in a pattern such that the spectator can press his or her fingers into the slits to wear the novelty hand. The invention has an orifice in one of the comers of the bottom of said foam rubber body and a hand strap which is connected to the body through the orifice. The covering can be affixed with team logos, colors, slogans or the like such that the spectator can visually communicate his or her support.

Abstract: The invention provides a temperature-stable liquid droplet comprising a terature-stable hydrocolloid membrane. The hydrocolloid is chosen from low methoxy pectin, Konjac mannan, sodium alginate, or a mixture thereof. The membrane encapsulates a droplet of an edible product or a droplet containing a microorganism, an enzyme or a cell.

Abstract: A method and single solution denaturation and hybridization solution useful with synthetic oligonucleotide probes for hybridizing DNA or RNA sequences by in situ hybridization. The inventive protocol employs synthetic oligonucleotide probes and a glycerol-based hybridization solution which is particularly useful in fluorescence labeling of chromosomes X, Y, 13, 18 and 21 in human lymphocytes, amniocytes and metaphase chromosomes, with the label being sufficiently stable to permit archival storage of the labeled sample for later hybridization or analysis.

Abstract: A non-constricting brassiere that provides limited support comprising a single piece of fabric having a front panel and a continuous rear panel with shoulder straps connected from said panels. The shoulder straps are a continuation of the material of the front and rear panels. The invention has neck and arm holes that are edged with lightweight elastic or aesthetically pleasing knitted trim. The front and rear panels are centrally connected at the front panel to form a seam, the seam having gathers. Affixed to the lower portion of the front and rear panels is a continuous sewn hem. The present invention does not use underwires, hardware, heavy elastic, binding or seaming in sensitive underarm or breast areas where lymph nodes are numerous, nor does it use such features so as to cause the wearer discomfort in the other areas of the body the bra contacts. The preferred bra provides only limited breast support so as to not adversely affect lymphatic circulation and to increase comfort.

Abstract: A charge-flow separation apparatus (CFS) for enriching rare cell populations, particularly fetal cells, from a whole blood sample by separating the rare cell fractions from whole fractions according to the relative-charge density and/or the relative binding affinity for a leukocyte depletion solid phase matrix is described. The apparatus having an internal cooling system allows for dissipating heat generated by the electric field of the apparatus. The internal cooling system, consisting of a plurality of cooling tubes to circulate coolant material, prevents cellular degradation typically associated with the high heat generated by the electric field and permits the use of a higher voltage gradient to shorten separation times.