Patents Represented by Attorney, Agent or Law Firm Stanley A. Kim
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Patent number: 8242074Abstract: The invention is based on the discovery that interleukin-1 alpha (IL-1alpha) is expressed on the proinflammatory CD14+CD16+ monocyte subset. Importantly, since IL-1alpha appears to be almost exclusively expressed on this monocyte subset and not other leukocytes, it represents an ideal marker for targeting the CD14+CD16+ monocyte subset. The effectiveness of an agent that depletes such pathogenic cells or modulates IL-1alpha function on such cells type can be monitored by assessing CD14+CD16+ monocyte levels or functionality.Type: GrantFiled: September 14, 2009Date of Patent: August 14, 2012Assignee: XBiotech, Inc.Inventor: John Simard
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Patent number: 8187817Abstract: Methods of detecting individuals at risk for atherosclerosis and related vascular diseases involving the detection of IL-1? autoantibodies, as well as therapeutic methods to prevent or treat atherosclerosis and related vascular disease by administering a pharmaceutical composition comprising IL-1? autoantibodies.Type: GrantFiled: July 26, 2006Date of Patent: May 29, 2012Assignee: XBiotech, Inc.Inventors: John Simard, Klaus Bendtzen
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Patent number: 8142780Abstract: A pharmaceutical composition includes a purified antibody and a pharmaceutically acceptable carrier. The antibody can be a monoclonal antibody having both an antigen-binding portion that binds at least one bacterial antigen and a constant region that does not bind staphylococcal protein A.Type: GrantFiled: August 31, 2010Date of Patent: March 27, 2012Assignee: STROX Biopharmaceuticals, LLCInventor: Stanley Arthur Kim
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Patent number: 8034337Abstract: Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1? and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.Type: GrantFiled: June 1, 2009Date of Patent: October 11, 2011Assignee: Xbiotech, Inc.Inventor: John Simard
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Patent number: 7795402Abstract: A pharmaceutical composition includes a purified antibody and a pharmaceutically acceptable carrier. The antibody is enriched for immunoglobulins having both an antigen-binding portion that binds a Staphylococcus aureus capsular polysaccharide antigen and a constant region that does not bind staphylococcal protein A.Type: GrantFiled: July 2, 2009Date of Patent: September 14, 2010Assignee: STROX Biopharmaceuticals, LLCInventor: Stanley Arthur Kim
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Patent number: 7569677Abstract: A composition including a purified antibody conjugated with at least one antibiotic, the antibody having an antigen-binding portion that binds at least one antigen derived from Staphylococcus or Streptococcus.Type: GrantFiled: June 27, 2002Date of Patent: August 4, 2009Assignee: STROX Biopharmaceuticals, LLCInventor: Stanley A. Kim
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Patent number: 7547770Abstract: A method (100) and a system (200) for processing mammalian bodily fluids to isolate target peptides and proteins. The method can include the steps of passing a mammalian bodily fluid through at least one ion exchange column (204). The ion exchange column can include an anionic resin and/or a cationic resin. The ion exchange column can be selected to remove large particles at a first pH level selected to remove such large particles at a maximum fluid pressure of 30 pounds per square inch (psi), for example less than 10 psi. The large particles can be released from the ion exchange column with a rinse solution having a pH selected for releasing the large particles. The pH of the fluid then can be adjusted to be a value less than 5.0, and the fluid can be filtered with a microfilter or ultrafilter (210).Type: GrantFiled: November 3, 2004Date of Patent: June 16, 2009Assignee: Advanced Protein SystemsInventors: Andrew Keech, Rafael Jimenez-Flores
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Patent number: 6887005Abstract: A notebook computer features a computer body with a top panel, a keyboard, and a pointing device; and a wrist support attached to the top panel whereby it does not interfere with the operation of the keyboard or pointing device. The wrist support is compressible and has a base with having a surface area of less than 60 cm2 and a means for attaching the wrist support to the top panel of the notebook computer.Type: GrantFiled: September 22, 2003Date of Patent: May 3, 2005Inventor: Stanley A. Kim
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Patent number: 6780622Abstract: An enzyme having diterpene cyclase activity has been purified from P. elisabethae using a series of chromatography steps. The purified enzyme has an apparent molecular weight of about 47 kilodaltons and an isoelectric point of about 5.1. The purifed enzyme catalyzed the cyclization of geranyl geranyl diphosphate to elisabethatriene.Type: GrantFiled: January 27, 2003Date of Patent: August 24, 2004Assignee: Florida Atlantic UniversityInventors: Russell Kerr, Amber Kohl
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Patent number: 6680051Abstract: Polymers containing amino acid and/or polypeptide moieties in their backbones or pendant to their backbones are made by metathesis. A method of making an amino acid or polypeptide containing polymer includes the steps of: providing a amino acid, amino alcohol, or polypeptide-containing monomer; forming a reaction mixture by contacting the monomer with an agent capable of catalyzing the polymerization of the monomer into a polymer; and placing the reaction mixture under conditions that result in the formation of the polymer in reaction mixture.Type: GrantFiled: August 20, 2001Date of Patent: January 20, 2004Assignee: University of FloridaInventors: Kenneth B. Wagener, Timothy E. Hopkins, James H. Pawlow, Fernando J. Gomez
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Patent number: 6677119Abstract: Nucleic acids and polypeptides correlated with cancer are disclosed. Also disclosed are methods of detecting cancer in a biological sample by determining expression of a colon carcinoma related gene (CCRG) or protein in that sample.Type: GrantFiled: December 5, 2000Date of Patent: January 13, 2004Assignee: Florida Atlantic UniversityInventor: Ramaswamy Narayanan
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Patent number: 6649145Abstract: Disclosed are methods and compositions for increasing tissue oxygen levels by administration of superoxygenated compositions of tissue surfaces. The methods are applicable to treatment of a wide variety of conditions including burns, bedsores, ulcers, necrosis and anaerobic infections.Type: GrantFiled: January 18, 2002Date of Patent: November 18, 2003Assignee: Hydron Technologies, Inc.Inventors: Terrence S. McGrath, Charles Fox
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Patent number: 6638763Abstract: Using a novel culture approach, previously unknown populations of neural progenitor cells have been found within an adult mammalian brain. By limiting cell-cell contact, dissociated adult brain yields at least two types of cell aggregates. These aggregates or clones of stem/precursor cells can be generated from adult brain tissue with significantly long postmortem intervals. Both neurons and glia arise from stem/precursor cells of these cultures, and the cells can survive transplantation to the adult mammalian brain.Type: GrantFiled: October 1, 1999Date of Patent: October 28, 2003Assignee: University of Tennessee Research FoundationInventors: Dennis A. Steindler, Eric D. Laywell, Valery G. Kukekou, L. Brannon Thomas
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Patent number: 6630576Abstract: This invention provides mutant hIL13 molecules include those made by substituting one or more of the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other amino acid residues. Multiply mutated forms of hIL13 conjugated to cytotoxins are used to preferentially target diseased cells over non-diseased cells.Type: GrantFiled: August 24, 2001Date of Patent: October 7, 2003Assignee: Pennsylvania State Research FoundationInventor: Waldemar Debinski
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Patent number: 6630491Abstract: Method of using anabaseine, DMAB-anabaseine, and anabaseine for stimulating brain cholinergic transmission and a method of making anabaseine.Type: GrantFiled: June 7, 1995Date of Patent: October 7, 2003Assignee: University of FloridaInventors: John A Zoltewicz, William R. Kem, Edwin M. Meyer
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Patent number: 6605748Abstract: Functionalized allylic olefins are condensed by metathesis using the catalyst 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ruthenium benzylidene [Ru*].Type: GrantFiled: August 23, 2002Date of Patent: August 12, 2003Assignee: University of FloridaInventors: Kenneth Wagener, James Pawlow, John Sworen
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Patent number: 6586256Abstract: Chemical sensor compositions and methods for quantifying analytes are described. The chemical sensors include analyte-binding moieties and reporter moieties covalently attached to a framework including two trityl groups connected by a linear spacer such as ethyne or butadiyne. The sensors chelate an analyte across the acetylene axis of the molecule to stabilize the molecule in an eclipsed rotamer conformation. This conformation causes the sensors to emit a measurable signal.Type: GrantFiled: May 2, 2000Date of Patent: July 1, 2003Assignee: The Penn State Research FoundationInventors: Timothy E. Glass, Joseph Raker, Ricardo Moran
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Patent number: 6576232Abstract: This invention provides mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13 molecules include those made by substituting the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other amino acid residues. Some of the mutants retain the ability to bind and cause signaling through IL13 receptors, while other mutants do not.Type: GrantFiled: October 5, 2000Date of Patent: June 10, 2003Assignee: The Penn State Research FoundationInventors: Waldemar Debinski, Jeffrey P. Thompson
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Patent number: 6573110Abstract: A combinatorial chemistry system allows for the dual processing of different molecules coated on a library of beads. The system includes beads coated with different molecules on each bead, a bead holder, screening equipment and characterization equipment. Molecules on the beads are both screened and characterized simultaneously.Type: GrantFiled: December 15, 1999Date of Patent: June 3, 2003Assignee: The Penn State Research FoundationInventors: Robert J. Hessler, Robert Braun, Nicholas Winograd
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Patent number: 6569632Abstract: Disclosed are methods for identifying the presence of Pasteuria endospores in soil and soil extract samples and distinguishing between Pasteuria spp and non-Pasteuria spp in the samples. Also disclosed are methods for identifying the presence of Pasteuria endospores after immobilizing a soil extract or an isolated portion of the soil extract on a substrate. Further, methods for quantifying the approximate number of Pasteuria endospores in a soil sample are described.Type: GrantFiled: October 19, 2000Date of Patent: May 27, 2003Assignee: University of FloridaInventors: James F. Preston, Donald W. Dickson, John D. Rice, Jonathan H. Charnecki, Janete A. Brito, Liesbeth M. Schmidt