Patents Represented by Attorney Stanley Sacks
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Patent number: 5911862Abstract: A polymeric material which to form a stable, reproducible interface between the ionic and electronic domains of an ion selective sensor, or an ion selective field effect transistor, or the like is provided. When employed in an ion selective sensor, the polymeric material is advantageously provided over a solid internal reference electrode and an ion selective membrane is provided thereover. According to one embodiment, the polymeric material of the invention includes less than about 1.63.times.10.sup.21 immobilized charged sites per gram (less than about 2.72 millaequivalents/gram). According to another embodiment, the polymeric material includes immobilized sites of charge opposite that of mobile ions involved in the redox couple. A preferred polymeric material comprises a copolymer of methacrylamidopropyltrimethylammoniumchloride and methylmethacrylate. In a particularly advantageous embodiment, the ion selective membrane has little or no plasticizer.Type: GrantFiled: September 8, 1997Date of Patent: June 15, 1999Assignee: Chiron Diagnostics CorporationInventor: Andy D. C. Chan
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Patent number: 5897758Abstract: An improvement to the coated wire electrode has been accomplished via inclusion of a fortiophore into a sensor device. Sensor devices of the present invention include: an internal reference element; a membrane; and a fortiophore. Fortiophores are neutral charge carriers, which complex reversibly a corresponding ion of the conductive material used as the internal reference element. The fortiophore provides an electrochemically defined and reproducible solid internal contact between the membrane and the internal reference element. This solid internal contact, for example, in ion selective sensors, provides more reproducible potential offsets and better precision, and faster wet up. The fortiophores can be utilized in other electrochemical devices.Type: GrantFiled: August 1, 1997Date of Patent: April 27, 1999Assignee: Chiron Diagnostics CorporationInventors: John Musacchio, Urs Oesch
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Patent number: 5804049Abstract: A polymeric material which to form a stable, reproducible interface between the ionic and electronic domains of an ion selective sensor, or an ion selective field effect transistor, or the like is provided. When employed in an ion selective sensor, the polymeric material is advantageously provided over a solid internal reference electrode and an ion selective material is provided thereover. According to one embodiment, the polymeric material of the invention includes less than about 1.63.times.10.sup.21 immobilized charged sites per gram (less than about 2.72 millaequivalents/gram). According to another embodiment, the polymeric material includes immobilized sites of charge opposite that of mobile ions involved in the redox couple. A preferred polymeric material comprises a copolymer of methacrylamidopropyltrimethylammoniumchloride and methylmethacrylate.Type: GrantFiled: September 15, 1993Date of Patent: September 8, 1998Assignee: Chiron Diagnostics CorporationInventor: Andy D. C. Chan
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Patent number: 5785830Abstract: An improved active electrode for use in planar sensors has been discovered, the electrode prepared by a process comprising combining a base component with a metal paste and heating the paste in the presence of air for a time sufficient to oxidize a portion of the electrode to produce the metal/metal oxide electrode. The electrodes may be incorporated into various planar sensor formats, particularly pH and CO.sub.2 sensors.Type: GrantFiled: August 7, 1996Date of Patent: July 28, 1998Assignee: Chiron Diagnostics CorporationInventors: Joseph S. Foos, John S. Benco
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Patent number: 5770028Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: December 19, 1996Date of Patent: June 23, 1998Assignee: Chiron Diagnostics CorporationInventors: Thomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Peter G. Edelman
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Patent number: 5738992Abstract: An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.Type: GrantFiled: April 9, 1996Date of Patent: April 14, 1998Assignee: Chiron CorporationInventors: Thomas A. Cook, Rudolf E. Slovacek, Walter F. Love, Richard L. Schulkind, Irene M. Walczak
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Patent number: 5711868Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: January 27, 1998Assignee: Chiron Diagnostics CorporatiionInventors: Thomas C. Maley, Paul A. D'Orazio, Bonnie C. Dalzell, Peter G. Edelman, James E. Flaherty, Richard W. Mason, Robert R. McCaffrey
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Patent number: 5707502Abstract: A sensor for measuring a concentration of an analyte in a solution. The sensor comprises a substrate layer, an electrode layer and an immobilized enzyme layer. The sensor further includes an enzyme/polymer layer and/or a hydrophobic layer. The enzyme/polymer layer includes an enzyme disposed within a polymer matrix. The hydrophobic layer is formed from a material that is more hydrophobic than the immobilized enzyme layer material. In certain embodiments, the sensor includes the enzyme/polymer layer and the hydrophobic layer disposed between the enzyme/polymer layer and the immobilized enzyme layer such that the enzyme/polymer layer is disposed along the hydrophobic layer within an area above the immobilized enzyme layer.Type: GrantFiled: July 12, 1996Date of Patent: January 13, 1998Assignee: Chiron Diagnostics CorporationInventors: Robert McCaffrey, Katarina Tkacik, Brian Holman, James Flaherty, Josef Brown, Peter Edelman
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Patent number: 5702575Abstract: An improved active electrode for use in planar sensors has been discovered, the electrode prepared by a process comprising combining a base component with a metal paste and heating the paste in the presence of air for a time sufficient to oxidize a portion of the electrode to produce the metal/metal oxide electrode. The electrodes may be incorporated into various planar sensor formats, particularly pH and CO.sub.2 sensors.Type: GrantFiled: November 1, 1995Date of Patent: December 30, 1997Assignee: Chiron Diagnostics CorporationInventors: Joseph S. Foos, John S. Benco
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Patent number: 5696314Abstract: An electrochemical sensor is designed for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by providing the multilayer enzyme electrode membrane having both nonporous and microporous layers. The microporous layer is formed from a polymer binder, a polymer powder, a surfactant and a mineral powder. In another aspect, certain of these goals are achieved by the use of a layer comprised of an enzyme disposed within a polymer matrix. In certain embodiments, the multilayer enzyme electrode membrane includes an outermost layer which is capable of dissolving in the sample solution such that the interface between the multilayer enzyme electrode membrane and the sample solution is continually renewed.Type: GrantFiled: July 12, 1996Date of Patent: December 9, 1997Assignee: Chiron Diagnostics CorporationInventors: Robert McCaffrey, Bonnie Dalzell, Katarina Tkacik, Susan Holbert, Mark Boden, James Flaherty, Michael Flanagan, Josef Brown, Kimiya Takeshita, Peter Edelman
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Patent number: 5667983Abstract: It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one or (2) 5-bromo-5-nitro-1,3-dioxane, that are used in clinical diagnostic reagents. It has also been found that these buffers and certain surfactants, such as BRIJ 700 and related hydrophilic surfactants, enhance the precision and accuracy of enzyme biosensors.Type: GrantFiled: October 24, 1994Date of Patent: September 16, 1997Assignee: Chiron Diagnostics CorporationInventors: Allison L. Abel, Paul A. D'Orazio, Bonnie C. Dalzell, Robert R. McCaffrey, Laura S. Uretsky
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Patent number: 5616222Abstract: A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.Type: GrantFiled: September 15, 1995Date of Patent: April 1, 1997Assignee: Chiron Diagnostics CorporationInventors: Thomas C. Maley, Paul A. D'Orazio, Peter G. Edelman, John A. Zalenski
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Patent number: 5166249Abstract: The invention relates to polymer mixtures which comprise a polyphenylene ether, a polyoctenylene and TiO.sub.2 or BaSO.sub.4. The presence of TiO.sub.2 or BaSO.sub.4 leads to an improvement of the mechanical properties.Type: GrantFiled: April 9, 1991Date of Patent: November 24, 1992Assignee: General Electric Co.Inventors: Theodorus L. Hoeks, Christian M. E. Bailly, Johannes H. G. M. Lohmeijer, Wilhelmus M. M. Roovers
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Patent number: 5103812Abstract: Combinations of alkyl siloxy siloxane-containing polymers admixed with liquid polydimethylsiloxanes are excellent non-stinging, non-irritating liquid coating material for forming films which act as conformable bandages adhering to and protecting nails, skin and mucous membrane wounds from abrasion, contamination, and desiccation, while stopping pain from exposed nerve ends and allowing body fluid evaporation.Type: GrantFiled: February 19, 1991Date of Patent: April 14, 1992Assignees: Rochal Industries, Inc., Rochal Industries, Inc.Inventors: Ann B. Salamone, Joseph C. Salamone, Alfred P. Olson
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Patent number: 5059646Abstract: An improved thermoplastic resin composition is described, containing polyphenylene ether resin, polyamide resin, and certain organophosphorus compounds. Particular examples of the organophosphorus compounds are dimethyloxazolinylmethylbisvinylphenyl phosphate and bis(dimethyloxazolinylmethyl)vinylphenyl phosphate. The compositions are characterized by excellent mechanical properties and oil resistance.Type: GrantFiled: December 13, 1989Date of Patent: October 22, 1991Assignee: General Electric Co.Inventors: Masataka Morioka, Hiromi Ishida
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Patent number: 4801299Abstract: A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the body or externally on the body in a variety of medical uses.Type: GrantFiled: February 22, 1984Date of Patent: January 31, 1989Assignee: University Patents, Inc.Inventors: Klaus Brendel, Raymond C. Duhamel
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Patent number: D253713Type: GrantFiled: January 5, 1978Date of Patent: December 18, 1979Assignee: Acro IncorporatedInventors: Mark L. Robinson, Paul E. Brefka
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Patent number: D254370Type: GrantFiled: April 19, 1978Date of Patent: March 4, 1980Assignee: Barnet WeinsteinInventors: Barnet Weinstein, John F. Price
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Patent number: D257433Type: GrantFiled: June 22, 1979Date of Patent: October 21, 1980Inventors: Barnet Weinstein, John F. Price
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Patent number: D258780Type: GrantFiled: August 24, 1978Date of Patent: April 7, 1981Inventor: Theodore L. Wasserman