Abstract: The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators.
Type:
Grant
Filed:
April 27, 2010
Date of Patent:
February 7, 2012
Assignee:
Genentech, Inc.
Inventors:
Daniel K. Kirchhofer, Robert A. Lazarus, Christian Wiesmann