Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.

Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.

Abstract: This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-

Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.

Abstract: The present invention provides a process for the preparation of functionalized indolizidines comprising the steps and products disclosed within this application.

Abstract: Olefin-based materials react with a range of catalysts and catalytic systems to form catalytic matrices, which are employed in the production of a variety of polyolefin products.

Abstract: A moisture reactive hot melt adhesive composition formed by admixing components including a polyisocyanate, an amorphous polyol, tri-C1-C6-alkyl citrate in the amount of 1.3 to 6% by weight based on the weight of said adhesive composition, and styrene/allyl alcohol copolymer having a hydroxyl number of 100-300 and Mn of 1,000-4,000 in the amount of 0.1 to 10% by weight based on the weight of said adhesive composition, wherein the ratio of NCO/OH groups of the components on an equivalents basis is from 1.05 to 2.5, the components being free from crystalline polyesters and polyethers and the components containing less than 1%, by weight based on the total weight of the components, of water is provided. Also a method for forming the adhesive composition and a method for bonding two substrates using the adhesive are provided.

Abstract: A method for preparing multi-layer protective coatings having enhanced durability with easy removability under conventional stripping conditions is disclosed. The invention is based on applying to a substrate, a first-coating composition that is removable, followed by application of a second-coating composition that is highly durable but not readily removable. Preferred second-coating compositions are based on polymers that provide highly crosslinked ‘non-removable’ (under conventional stripping conditions) coatings if used alone. The resultant multi-layer coating compositions provide enhanced detergent resistance while retaining easy overall removability properties.

Abstract: Hydrophobic, oil-absorbing polymeric compositions, prepared from high levels of hydrophobic monomers, are provided for transferring oily substances and hydrophobic materials to and from various surfaces in a heterogeneous medium. A reversible process is described for transferring oily substances and hydrophobic materials to and from various surfaces in a heterogeneous medium using oil-absorbing films, solid particles or dispersions of aqueous emulsion polymers prepared from hydrophobic monomers.

Abstract: Porous films are provided which include a blend of a film forming polymer and a non-film forming material, the film having a network of pores or channels throughout the film. The porous polymer films are formed between 0° and 80° C. retain porosity at elevated temperatures and are non-friable. A process for preparing porous polymer films and their applications are disclosed.

Abstract: A high productivity catalyst for bisphenol-A has been discovered which comprises strongly acidic cation-exchange resin spheres produced from a polystyrene/divinylbenzene (PS/DVB) copolymer sulfonated under conditions to introduce sulfone cross-linking. Surprisingly, the sulfone cross-linking improves the resistance to deformation but does not have a negative effect on the activity and selectivity of the catalyst in bisphenol-A production.

Abstract: A process for preparing an aqueous emulsion polymer including providing at least one ethylenically unsaturated monomer and a free radical redox initiator system under emulsion polymerization conditions, the redox initiator system including an oxidant; a reductant and a metal promoter complex, and effecting the polymerization of at least some of the ethylenically unsaturated monomer is provided. Also provided is a process for reducing the residual ethylenically unsaturated monomer content of an aqueous emulsion polymer.

Abstract: A new class of polymeric corrosion inhibiting compositions incorporating pendant heterocyclic groups which are surprisingly effective copper corrosion inhibitors are disclosed. The polymers form a protective barrier on metallic components to aqueous systems and remain substantive on metallic surfaces over a wide pH range. Moreover, the polymers are resistant to oxidizing biocides, and are substantially impervious to repeated or prolonged exposure to corrosive agents.

Abstract: Disclosed are compositions containing biologically active compounds that slowly release the biologically active compound. These compositions may be directly incorporated into the locus to be protected or may be applied to a structure in a coating.

Abstract: Aqueous compositions having enhanced thickening properties containing lipophilically-modified copolymer thickeners and one or more hydrophilic surfactants are disclosed. In particular, aqueous compositions containing (i) lipophilically-modified copolymers containing at least 5% of selected lipophilically-modified components and (ii) surfactants having an HLB value of greater than 15 are useful for the thickening of a range of personal, domestic and industrial products.

Abstract: An adjustable clamp holder having multiple securing mechanisms for each attachment structure of the clamp body is disclosed. The clamp has utility in fastening together support rods and supporting an apparatus or laboratory equipment. The clamp holder obviates the limited securing capabilities and safety concerns associated with previously known clamping devices.

Abstract: The present invention relates to an aqueous coating composition having low volatile organic compounds (VOC) and producing a coating having excellent durability and resistance properties. The coating composition contains acetoacetate functional polymer and divalent metal ions. Coating compositions of the present invention are particularly useful in ink, polish and coating compositions where a tough, resistant coating is required. The coating composition can be used on various substrates such as floors, walls wood, metal, plastic, stone, paper, leather and concrete.

Abstract: Polymer compositions derived from selected monoethylenically unsaturated (C3-C6)carboxylic acid monomers, (C1-C4)alkyl (meth)acrylate ester monomers and alkoxylated (meth)acrylate monomers used in certain weight ratios to provide enhanced detergent and cleaning performance are disclosed. Polymer compositions containing from 5 to 40% of monoethylenically unsaturated (C3-C6)carboxylic acid monomer, from 35 to 65% of (C1-C4)alkyl (meth)acrylate ester monomer and from 20 to 60% of alkoxylated (meth)acrylate monomer provide improved cleaning performance in laundry detergent formulations relative to conventional polymer compositions.

Abstract: A polymer composition comprising an aqueous suspension or dispersion of a water insoluble polymer of ethylenically unsaturated monomers, said polymer having a Tg of at least 35° C. and 25% to 65% by weight units of iso-butyl methacrylate (IBMA) and n-butyl methacrylate (BMA), and 3% to 50% by weight units of at least one acidic monomer. Floor polish compositions comprising said polymer may have improved repeatable high speed burnish response.

Abstract: The present invention relates to pellets comprising one or more active ingredients; and either one or both of: (a) one or more binders incorporated within the body of the pellet; and (b) one or more coating materials on the surface of the pellet; characterized in that either one or both of the binders and the coating materials comprise one or more polymers with a Tg in the range −85 to +35°C., and, optionally, wherein the coating and/or binder materials comprise at least one multi-phase polymer and further wherein at least one of the phases of the multi-phase polymer has a Tg in the range −85 to +35° C.