Abstract: This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non- aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.
Type:
Grant
Filed:
June 13, 1997
Date of Patent:
August 3, 1999
Assignee:
ALZA Corporation
Inventors:
Cynthia L. Stevenson, Steven J. Prestrelski
Abstract: This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.
Type:
Grant
Filed:
June 13, 1997
Date of Patent:
June 29, 1999
Assignee:
ALZA Corporation
Inventors:
Cynthia L. Stevenson, Sally A. Tao, Steven J. Prestrelski, James B. Eckenhoff, deceased, Jeremy C. Wright, John J. Leonard, Jr.
Abstract: A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure.
Type:
Grant
Filed:
October 8, 1997
Date of Patent:
February 16, 1999
Assignee:
ALZA Corporation
Inventors:
Judy A. Magruder, James B. Eckenhoff, deceased, Richard Cortese, Jeremy C. Wright, John R. Peery, James B. Pike, Urano A. Robinson, Jonathan P. Smith, Lyle E. Ziemann