Abstract: This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula: that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.
Type:
Grant
Filed:
July 17, 2003
Date of Patent:
March 27, 2007
Assignee:
Warner-Lambert Company
Inventors:
Cleo J. Chivikas Connolly, Christopher James Deur, James Marino Hamby, Denton Wade Hoyer, Chris Limberakis, Jessica Elizabeth Reed, Mel Conrad Schroeder, Clarke Taylor