Patents Represented by Attorney, Agent or Law Firm Steven F. Weinstock
  • Patent number: 4613589
    Abstract: Derivatives of 3-deoxy-D-manno-2-octulosonic acid (KDO) are potent inhibitors of bacterial enzymes and a novel class of antibacterial agents.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: September 23, 1986
    Assignee: Abbott Laboratories
    Inventors: William Rosenbrook, Paul A. Lartey, David A. Riley
  • Patent number: 4613590
    Abstract: Aminodeoxy derivatives of 3-deoxy-D-manno-2-octulosonic acid (KDO) are potent inhibitors of bacterial enzymes and a novel class of antibacterial agents.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: September 23, 1986
    Assignee: Abbott Laboratories
    Inventors: William Rosenbrook, Paul A. Lartey, David A. Riley
  • Patent number: 4607032
    Abstract: Quino-benoxazine compounds having the formula: ##STR1## wherein R.sub.2 is one or more substituents, R.sub.1 is a hydrogen or a carboxy-protecting group and Z is an amine group or an aliphatic heterocyclic group. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: August 19, 1986
    Assignee: Abbott Laboratories
    Inventor: Daniel T. Chu
  • Patent number: 4560558
    Abstract: Disclosed are compounds of the formula: ##STR1## wherein X is hydrogen, loweralkyl, loweralkoxy or halo, Y is hydroxymethyl, carboxyl, carboxamido or carboloweralkoxy, and R is cyclohexyl, benzyl, norbornyl, loweralkyl, or a pharmaceutically acceptable salt thereof.The compounds are effective as diuretic agents.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: December 24, 1985
    Assignee: Abbott Laboratories
    Inventors: James A. Parks, Jacob J. Plattner
  • Patent number: 4558070
    Abstract: Acid salts of valproic acid having the structure: ##STR1## wherein M is potassium, cesium or rubidium. The salts of the invention are useful in the treatment of epileptic seizures, and can be conveniently formulated into oral dosage forms.
    Type: Grant
    Filed: October 26, 1983
    Date of Patent: December 10, 1985
    Assignee: Abbott Laboratories
    Inventors: John F. Bauer, Douglas M. Shada
  • Patent number: 4542133
    Abstract: 1,2-methylenedioxy quino-benoxazine derivatives having the formula: ##STR1## wherein R.sub.2 is a substituent and R.sub.1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: September 17, 1985
    Assignee: Abbott Laboratories
    Inventor: Daniel T. Chu
  • Patent number: 4540694
    Abstract: 1-pyridine substituted quino-benoxazines having the formula: ##STR1## wherein X is halogen or hydrogen; R.sub.2 is a substituent; and R.sub.1 is hydrogen or a carboxy protecting group.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: September 10, 1985
    Assignee: Abbott Laboratories
    Inventor: Daniel T. Chu
  • Patent number: 4533663
    Abstract: Quino-benzothiazine compounds having the formula ##STR1## wherein R.sub.2 is one or more constituents; R.sub.1 is a hydrogen or a carboxy-protecting group; and Z is an amine group or an aliphatic heterocyclic group. The compounds have antibacterial activity.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: August 6, 1985
    Assignee: Abbott Laboratories
    Inventor: Daniel T. Chu
  • Patent number: 4529725
    Abstract: 1-pyridine substituted quino-benzothiazine having the formula: ##STR1## wherein X is halogen or hydrogen; R.sub.2 is a substituent; and R.sub.1 is hydrogen or a carboxy protecting group.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: July 16, 1985
    Assignee: Abbott Laboratories
    Inventor: Daniel T. Chu
  • Patent number: 4528285
    Abstract: 1,2-methylenedioxy quino-benzothiazine derivatives having the formula ##STR1## wherein R.sub.2 is a substituent and R.sub.1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: July 9, 1985
    Assignee: Abbott Laboratories
    Inventor: Daniel T. Chu
  • Patent number: 4517313
    Abstract: A method of manufacturing polyurethane foam by a reaction of organic polyisocyanates and polyols in the presence of a foaming agent and catalysts comprises using as the catalyst, a salt of carbonic acid and polyamine represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are an alkyl group having 1-4 carbon atoms or R.sub.1 and R.sub.2 are combined to form a heterocyclic ring having 3-6 carbon atoms together with a nitrogen atom; and R.sub.3 is an alkylene group.
    Type: Grant
    Filed: April 11, 1984
    Date of Patent: May 14, 1985
    Assignee: Abbott Laboratories
    Inventor: Keiichi Nakatani
  • Patent number: 4505932
    Abstract: A method of producing .alpha..sub.2 -adrenergic receptor agonist activity by contacting an .alpha..sub.2 -adrenergic receptor with an effective amount of a compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently selected from hydrogen or loweralkyl of 1 or 2 carbon atoms, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: March 19, 1985
    Assignee: Abbott Laboratories
    Inventors: John F. DeBernardis, David L. Arendsen
  • Patent number: 4503056
    Abstract: Described are compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently of one another denote hydrogen or loweralkyl, X is hydroxy or amino, and Y is hydrogen, loweralkyl, loweralkoxy, benzyl or ##STR2## wherein W and Z independently of one another denote hydrogen, halo, loweralkyl, loweralkoxy, trifluoromethyl, acetamido, cyano, diloweralkylamino, phenoxy and loweralkylmercapto, and pharmaceutically acceptable salts thereof.The compounds are effective as anti-inflammatory agents.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: March 5, 1985
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, Roland L. Walters
  • Patent number: 4500654
    Abstract: A catalyst and process are provided for producing polyurethanes by contacting an organic polyol and an organic isocyanate with a catalyst comprising an N-substituted alkoxyalkyl piperazine and preferably additionally comprising an N-alkoxyalkyl morpholine wherein the alkylene moieties of the morpholine and piperazine are independently selected from the group consisting of C.sub.1 to about C.sub.5 alkylene moieties, and wherein the alkoxy moieties are independently selected from the group consisting of C.sub.1 to about C.sub.3 alkoxy moieties.
    Type: Grant
    Filed: November 1, 1983
    Date of Patent: February 19, 1985
    Assignee: Abbott Laboratories
    Inventors: Russell O. Carlsen, Francois M. Casati, Daniel S. Raden
  • Patent number: 4500543
    Abstract: Disclosed herein are 1-aminomethyl-phthalans represented by the formula ##STR1## wherein R, R.sub.1, and R.sub.2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, thiomethyl, halo, or ##STR2## wherein R.sub.5 and R.sub.6 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula ##STR3## wherein R.sub.7 is loweralkyl of 1 to 4 carbon atoms; or R and R.sub.1, or R.sub.1 and R.sub.2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R.sub.1 or R.sub.2 must be other than hydrogen; and R.sub.3 and R.sub.4 are independently selected from hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula ##STR4## wherein m is 0, 1 or 2, p is 0 or 1, R.sub.8 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R.sub.9 and R.sub.
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: February 19, 1985
    Assignee: Abbott Laboratories
    Inventors: John F. Debernardis, David L. Arendsen
  • Patent number: 4476137
    Abstract: Described are compounds of the formula ##STR1## wherein R is hydrogen or loweralkyl, X, Y and W independently of one another denote hydrogen, halogen, loweralkyl, nitro, amino, amido, loweralkoxy, hydroxy, nitrile, methylsulfone, methylsulfoxide, methylmercapto, or trifluoromethyl; Z is oxygen, sulfur or --CH.sub.2 ; n and m are each an integer from 0 to 6 inclusive, or pharmaceutically acceptable salts thereof.The compounds are effective as anti-inflammatory agents.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: October 9, 1984
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, James D. Ratajczyk, Francis E. Fischer
  • Patent number: 4473666
    Abstract: A catalyst system and process are provided for producing polyurethane foams using a carboxylic acid blowing agent, wherein an organic polyol and an organic polyisocyanate are contacted with a catalyst system comprising a dialkylcyclohexylamine and an N-substituted alkoxyalkyl piperazine.
    Type: Grant
    Filed: January 30, 1984
    Date of Patent: September 25, 1984
    Assignee: Abbott Laboratories
    Inventors: Francois M. Casati, Daniel S. Raden, Francis W. Arbir
  • Patent number: 4473586
    Abstract: Disclosed herein are 1-aminoalkyl-3,4-dihydronaphthalenes represented by the formula ##STR1## wherein n is 1 or 2; R, R.sub.1, and R.sub.2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, thiomethyl, halo, or ##STR2## wherein R.sub.5 and R.sub.6 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula ##STR3## wherein R.sub.7 is loweralkyl of 1 to 4 carbon atoms; or R and R.sub.1, or R.sub.1 and R.sub.2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R.sub.1 or R.sub.2 must be other than hydrogen; and R.sub.3 and R.sub.4 are independently selected from hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula ##STR4## wherein m is 0, 1 or 2, p is 0 or 1, R.sub.8 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R.sub.9 and R.sub.
    Type: Grant
    Filed: May 3, 1982
    Date of Patent: September 25, 1984
    Assignee: Abbott Laboratories
    Inventors: John F. Debernardis, David L. Arendsen, Martin Winn
  • Patent number: 4456593
    Abstract: Described is the use of .psi.-aglycone and other derivatives of ristocetin A as antibacterial agents.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: June 26, 1984
    Assignee: Abbott Laboratories
    Inventors: Thomas R. Herrin, Alford M. Thomas
  • Patent number: 4456612
    Abstract: Described are compounds of the formula ##STR1## wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula ##STR2## wherein X' and Y' may be the same or different and are selected from hydrogen, loweralkyl, or halo, and Z' is hydrogen, loweralkyl, halo, hydroxy or loweralkoxy, or pharmaceutically acceptable salts thereof.The compounds possess diuretic activity.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: June 26, 1984
    Assignee: Abbott Laboratories
    Inventors: Jacob J. Plattner, Anthony K. Fung