Patents Represented by Attorney, Agent or Law Firm Steven J. Moore
  • Patent number: 6987123
    Abstract: The present invention relates to compounds of the general formula (I), there derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates, wherein all variables are as defined in the specification.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: January 17, 2006
    Assignee: Cadila Healthcare Limited
    Inventors: Braj Bhushan Lohray, Vidya Bhushan Lohray, Vijay Kumar Gajubhai Barot
  • Patent number: 6759663
    Abstract: The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: July 6, 2004
    Assignee: Ikonisys, Inc.
    Inventors: Petros Tsipouras, Triantafyllos Tafas
  • Patent number: 6635763
    Abstract: The present invention relates to a process for the preparation of thieno[3,2-c]pyridine derivatives having pharmacologically significant anti-aggregating and anti-thrombotic properties.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: October 21, 2003
    Assignee: Cadila Health Care Limited
    Inventors: Bipin Pandey, Vidya Bhushan Lohray, Braj Bhushan Lohray
  • Patent number: 6265167
    Abstract: The invention pertains to a novel method and construct for regulating gene expression through inhibition of gene expression by nuclear antisense RNA. The construct provides an efficient means for introducing, expressing and accumulating the antisense RNA in the nucleus. The antisense RNA hybridizes to the sense mRNA in the nucleus, thereby preventing both processing and cytoplasmic transport. The construct comprises a promoter, antisense sequences, and a cis- or trans-ribozyme which generates 3′-ends independently of the polyadenylation machinery and thereby inhibits the transport of the RNA molecule to the cytoplasm. The construct may also comprise a histone stem-loop structure that assists in stabilizing the transcripts against exonucleolytic degradation.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: July 24, 2001
    Inventors: Gordon G. Carmichael, David B. Batt, Zhong Liu
  • Patent number: 6253427
    Abstract: An improved garment loop for engaging and disengaging a button is described which includes at least one aperture for receiving a pin element. In a preferred embodiment, the loop is manufactured from a single piece of wire which provides for resilient movement of a button receiving portion by way of an overlapping element structure comprising a horizontal strap bar which includes a pair of generally flat stamped elements engaged together with a riveted pin.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: July 3, 2001
    Inventor: Stuart Gerson
  • Patent number: 5667986
    Abstract: A yeast promoter comprising the promoter of the (cytoplasmically located glycerol-3-phosphate dehydrogenase gene (GPD 1) possesses advantageous capacity to regulate the expression of heterologous polypeptides in yeasts transformed therewith. Expression of such polypeptides utilizing the GPD1 promoter can be regulated by the presence(repressed) or absence(derepressed) of high levels of sucrose or glucose in the fermentation medium. Alternatively, a non-repressing carbon source, such as glycerol or ethanol, can be added to the fermentation medium.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: September 16, 1997
    Assignee: Delta Biotechnology Limited
    Inventors: Andrew R. Goodey, Darrell Sleep, Dina Vakeria
  • Patent number: 5637504
    Abstract: A 2 .mu.m plasmid vector for transforming yeast, especially brewing yeast, much which comprises a DNA sequence allowing propagation of the plasmid in bacteria, two copies of the 74 base pair FLP recombination site of the 2 .mu.m plasmid in direct orientation and a DNA sequence coding for a protein or peptide of interest. The plasmid is so constructed that in yeast the bacterial DNA sequence is between the two recombination sites which are in direct orientation and is spontaneously lost following recombination. A "gene of interest" is preferable inserted at the SnaBI site.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: June 10, 1997
    Assignee: Delta Biotechnology Limited
    Inventors: Edward Hinchliffe, Simon A. Chinery
  • Patent number: 5625041
    Abstract: Problem: when proteins are purified using a protein-binding dye immobilised on a chromatographic matrix, the dye or a portion/derivative may leak into the eluant. Solution: an ion-exchange resin (e.g. Dowex-1) and a disrupting material (e.g. salt and a fatty acid such as sodium octanoate) are used to separate the dye from the protein.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: April 29, 1997
    Assignee: Delta Biotechnology Limited
    Inventors: Richard A. Johnson, Alan V. Quirk, John R. Woodrow