Patents Represented by Attorney, Agent or Law Firm Steven M. Cui
  • Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production
    Patent number: 6485942
    Abstract: Described herein are vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminus heparin binding domain. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with native VEGF thus providing variants having longer availability for therapeutic effect.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: November 26, 2002
    Assignee: Genentech, Inc.
    Inventors: Thomas F. Zioncheck, Geralyn G. DeGuzman, Rodney Gene Keck