Abstract: The invention provides novel 5-hydroxy-4-aryl- and 5-hydroxy-4-(arylthio)-2(5H)-furanones of the following structure: ##STR1## wherein R contains from about five to about twenty carbon atoms and is defined herein; X is oxygen, sulfur, SO.sub.2, NH, N(lower alkyl), N(lower acyl), aminocarbonyl, carbonyl, carbonylamino, CH.sub.2 or a carbon-carbon bond; Y is hydrogen, halogen, lower alkyl, nitro, alkylthio, perfluoroalkyl, hydroxy, or lower alkoxy(C.sub.1 -C.sub.8); Z is sulfur or a carbon-carbon bond; and Q is H, an alkyl of from 1-20 carbon atoms, COR', COOR', CONHR', PO(OR')2, PO(OR')R" wherein R' and R" are independently selected from the group consisting of H, an alkyl of from 1-20 carbon atoms, phenyl, and substituted phenyl and prodrugs thereof and pharmaceutically acceptable salts thereof.
Abstract: This invention relates to liquid sucralose concentrate compositions comprising sucralose, a preservative system, a buffering system and a liquid.
Type:
Grant
Filed:
August 18, 1992
Date of Patent:
January 24, 1995
Assignee:
McNeil-PPC, Inc.
Inventors:
Robert N. Antenucci, Richard L. Barndt, Kas Mohammed
Abstract: A process for the preparation of o-phthalaldehydes is disclosed comprising the steps of (1) halogenating an o-xylene and (2) hydrolysis of the resulting tetrahalogeno-o-xylene.
Abstract: Novel sunscreen compositions containing titanium dioxide having a particle size less than 10 m.mu. are described as well as methods of protecting the skin from damaging ultraviolet radiation.
Type:
Grant
Filed:
July 20, 1987
Date of Patent:
July 2, 1991
Assignee:
Johnson & Johnson Consumer Products, Inc.
Inventors:
Gulguhji R. Bhat, Martin K. O. Lindemann, Prakash Naik-Satam
Abstract: This invention relates to detergent compositions comprising at least one surfactant, at least one water-soluble nitrogen-containing polymer and a water-soluble, non-particulate substance capable of imparting a desired residual effect to a specific substrate such as the scalp or skin.
Type:
Grant
Filed:
February 18, 1983
Date of Patent:
August 14, 1990
Assignee:
Johnson & Johnson Consumer Products, Inc.
Inventors:
Robert J. Verdicchio, Diane L. Spilatro
Abstract: A skin care composition having improved effectiveness in preventing and treating acute inflammatory skin conditions comprising miconazole nitrate and zinc oxide.
Type:
Grant
Filed:
February 11, 1985
Date of Patent:
March 27, 1990
Assignee:
Johnson and Johnson Consumer Products, Inc.
Abstract: Alcohol/aqueous solutions of certain relatively insoluble imidazole derivatives, particularly micronazole and miconazole nitrate, are prepared to concentrations of at least 1.0 percent by weight active agent. The solutions are pharmacologically acceptable for topical application as the treatment of fungal skin infections and are readily applied by means of a pump sprayer.
Abstract: An aerosol mousse skin care composition comprising mineral oil, an emulsifier, water and a suitable propellant which exhibits desirable foam characteristics, good feel and is non-greasy.
Type:
Grant
Filed:
August 6, 1987
Date of Patent:
July 11, 1989
Assignee:
Johnson & Johnson Consumer Products, Inc.
Inventors:
Victoria F. Dole, Simon D. Monks, Robert J. Verdicchio
Abstract: This invention relates to liquid detergent compositions particularly suited for use on infant and children's clothing comprising an alkoxylated alcohol or alkoxylated alkyl phenol, a fatty acid or alkyl ether carboxylate, an alkyl phosphate ester or alkoxylate phosphoate ester, a water-soluble builder and water.
Type:
Grant
Filed:
February 16, 1988
Date of Patent:
June 6, 1989
Assignee:
Johnson & Johnson Consumer Products, Inc.
Abstract: A process for the preparation of 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl-4-chloro-4-deoxy-.alpha. -galactopyranoside comprising the steps of (a) reacting sucrose with a tritylating agent; (b) acetylating the tritylated reaction product; (c) detritylating the acetylated reaction product; (d) isomerizing the resulting penta-acetate; (e) chlorinating the isomerized product; and (f) deacetylating the chlorinated reaction product.
Type:
Grant
Filed:
October 20, 1986
Date of Patent:
January 31, 1989
Assignee:
McNeilab, Inc.
Inventors:
William Tully, Nicholas M. Vernon, Peter A. Walsh
Abstract: The present invention relates to skin care compositions with improved aesthetic and physical characteristics comprising a lotion, cream or anhydrous base and talc with specific ratios of the non-volatile ingredients to talc.
Type:
Grant
Filed:
March 13, 1987
Date of Patent:
January 24, 1989
Assignee:
Johnson & Johnson Consumer Products, Inc.
Inventors:
Gulgunji R. Bhat, Elvin R. Lukenbach, Ralph C. Stutzman
Abstract: Chlorination of carbohydrates and alcohols utilizing a chlorinating reagent selected from triphenylphosphine oxide/thionyl chloride, thiphenylphosphine oxide/phosgene, triphenylphosphine sulfide/thionyl chloride and triphenylphosphine sulfide/phosgene.
Type:
Grant
Filed:
October 20, 1986
Date of Patent:
November 8, 1988
Assignee:
McNeilab, Inc.
Inventors:
Eleanor A. O'Brien, Thomas O'Connor, Mathew R. J. Tuite, Leroy B. High
Abstract: Novel sunscreen compositions comprising at least one vinylogous amide compound are described as well as methods of protecting the human skin from damaging radiation.
Type:
Grant
Filed:
February 11, 1987
Date of Patent:
August 2, 1988
Assignee:
Johnson & Johnson Baby Products Company
Inventors:
Charles E. Clum, William V. Murray, Elvin R. Lukenbach
Abstract: Novel sunscreen compositions comprising at least one vinylogous amide compound are described as well as methods of protecting the human skin from damaging radiation.
Type:
Grant
Filed:
February 11, 1987
Date of Patent:
August 2, 1988
Assignee:
Johnson & Johnson Baby Products Company
Inventors:
William V. Murray, Charles E. Clum, Elvin R. Lukenbach
Abstract: Novel sunscreen compositions comprising at least one vinylogous amide compound are described as well as methods of protecting the human skin from damaging radiation.
Type:
Grant
Filed:
February 11, 1987
Date of Patent:
July 26, 1988
Assignee:
Johnson & Johnson Baby Products
Inventors:
Charles E. Clum, William V. Murrary, Elvin R. Lukenbach
Abstract: Detergent and cleansing compositions comprising at least one sulfated polyoxyalkylene condensation product and at least one amphoteric surfactant are provided.
Abstract: A process for the preparation of isethionic acid involving the reaction of sodium isethionate and hydrogen chloride in an alcoholic solvent is described.
Type:
Grant
Filed:
July 7, 1986
Date of Patent:
September 29, 1987
Assignee:
Johnson & Johnson Baby Products Company
Inventors:
Elvin R. Lukenbach, Prakash Naik-Satam, Anthony M. Schwartz
Abstract: Novel sunscreen compositions comprising at least one vinylogous amide compound are described as well as methods of protecting the human skin from damaging radiation.
Type:
Grant
Filed:
February 19, 1985
Date of Patent:
May 5, 1987
Assignee:
Johnson & Johnson Baby Products Company
Inventors:
William V. Murray, Charles E. Clum, Elvin R. Lukenbach