Patents Represented by Attorney Steven R. Crowley
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Patent number: 5082656Abstract: An antibacterial composition for topical administration, comprising from about 0.5 to about 10 percent of an antibacterial compound; from about one to about 30 percent of a non water soluble polymeric composition; from about 0.5 to about 40 percent of a plasticizer which plasticizes and polymeric composition; and from about 50 to about 95 percent of a solvent in which said polymeric composition and plasticizer are dissolved; whereby upon topical application of said antibacterial composition, said solvent will evaporate or penetrate the skin and leave a thin protective film of polymeric composition which retains said antibacterial compound against the skin.Type: GrantFiled: December 1, 1989Date of Patent: January 21, 1992Assignee: Abbott LaboratoriesInventors: Ho-Wah Hui, Chung-Chiang Hsu, Madhu K. Vadnere
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Patent number: 5082667Abstract: A solid pharmaceutical dosage in tablet triturate form is disclosed. The tablet triturate form includes a cementatory network constituted by a water-soluble but ethanol-insoluble carbohydrate. Also included are discrete particles of a solid, water-soluble but triglyceride-insoluble active ingredient, a polymer, an emulsifier, and sodium bicarbonate wherein the discrete particles have a triglyceride coating.Type: GrantFiled: April 22, 1991Date of Patent: January 21, 1992Assignee: Abbott LaboratoriesInventor: Kurt G. Van Scoik
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Patent number: 5063208Abstract: A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.Type: GrantFiled: June 29, 1990Date of Patent: November 5, 1991Assignee: Abbott LaboratoriesInventors: Saul H. Rosenberg, Kenneth P. Spina, Steven R. Crowley
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Patent number: 5059589Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-bezyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is substituted hydroxyalkylamino.Type: GrantFiled: March 2, 1990Date of Patent: October 22, 1991Assignee: Abbott LaboratoriesInventors: Herman H. Stein, Jacob J. Plattner, Steven R. Crowley
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Patent number: 5036051Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## where A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is Ch.sub.2 ; R.sub.1 is loweralkyl, cycloalkyl methyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-bezyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is substituted hydroxyalkyamino.Type: GrantFiled: March 2, 1990Date of Patent: July 30, 1991Assignee: Abbott LaboratoriesInventors: Herman H. Stein, Jacob J. Plattner
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Patent number: 5032577Abstract: A renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is C.dbd.O or CHOH; U is CH.sub.2 or NR.sub.2, provided that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, (alpha,alpha)-dimethylbenzyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.2 is hydrogen or loweralkyl; R.sub.3 is loweralkenyl, [(alkoxy)alkoxy]alkyl, (thioalkoxy)alkyl, lowerakenyl, benzyl or heterocyclic ring substituted methyl; R.sub.4 is loweralkyl, cycloalkylmethyl or benzyl; R.sub.5 is vinyl, formyl, hydroxymethyl or hydrogen; R.sub.7 is hydrogen or loweralkyl; R.sub.8 and R.sub.9 are independently selected from OH and NH.sub.2 ; and R.sub.6 is hydrogen, loweralkyl, vinyl or arylalkyl; provided that when R.sub.5 and R.sub.7 are both hydrogen and R.sub.8 and R.sub.9 are OH, the carbon bearing R.sub.5 is of the "R" configuration and the carbon bearing R.sub.Type: GrantFiled: December 18, 1987Date of Patent: July 16, 1991Assignee: Abbott LaboratoriesInventors: Anthony K. L. Fung, Dale J. Kempf, Jay R. Luly, Saul H. Rosenberg, Jacob J. Plattner
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Patent number: 5009897Abstract: A pharmaceutical granule comprising a core of active pharmaceutical agent and a coating of a polymer/microcrystalline cellulose is provided. These granules permit superior tableting of pharmaceutical agents whose physical properties in granule form render them unsuitable for conventional tableting.Type: GrantFiled: July 12, 1990Date of Patent: April 23, 1991Assignee: Abbott LaboratoriesInventors: Dale R. Brinker, Thomas L. Reiland
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Patent number: 5004651Abstract: An improved pharmaceutical preparation uses tromethamine and dibasic potassium phosphate or calcium carbonate to enhance stability.Type: GrantFiled: January 24, 1989Date of Patent: April 2, 1991Assignee: Abbott LaboratoriesInventor: Wallace E. Becker
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Patent number: 4994477Abstract: A renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; R.sub.1 is loweralkyl, loweralkenyl, alkoxyalkyl, [(alkoxy)alkoxy]alkyl, alkoxycarbonylalkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; R.sub.2 is hydrogen, loweralkyl, cycloalkylmethyl or benzyl; D is a substituent; or pharmaceutically acceptable salts or esters thereof.Also disclosed are renin inhibiting compositions, a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.Type: GrantFiled: March 24, 1988Date of Patent: February 19, 1991Assignee: Abbott LaboratoriesInventors: Dale J. Kempf, Saul H. Rosenberg, Jacob J. Plattner, Hing L. Shan, Biswanath De
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Patent number: 4994599Abstract: A process for producing a 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid by reacting an acctophenone with a dialkoxycarbonate to obtain the corresponding .beta.-ketoester, treating the .beta.-ketoester with a trialkylorthoformate in the presence of an acid anhydride followed by treatment with a substituted or unsubstituted amine to obtain the corresponding enaminoketoester, and then reacting the enaminoketoester with a strong base to obtain the corresponding quinoline-3-carboxylic acid ester. The acid ester may then be hydrolyzed, if desired, to obtain the quinoline-3-carboxylic acid. Also disclosed herein are compounds useful as intermediates useful in the production of quinoline-3-carboxylic acid.Type: GrantFiled: August 21, 1989Date of Patent: February 19, 1991Assignee: Abbott LaboratoriesInventor: Daniel T. Chu
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Patent number: 4992421Abstract: The present invention relates to novel luteinizing hormone releasing hormone antagonists ##STR1## The invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds for suppressing levels of sex hormones in male or female mammals.Type: GrantFiled: April 19, 1988Date of Patent: February 12, 1991Assignee: Abbott LaboratoriesInventors: Biswanath De, Hwan-Soo Jae, Jacob J. Plattner
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Patent number: 4988703Abstract: An antiviral compound of the formula: ##STR1## wherein A is selected from a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group and a heterocyclic isostere of a pyrimidin-1-yl group; andG and D are independently selected from hydrogen, C.sub.1 to C.sub.10 alkyl and substituted derivatives thereof, --OH, --C(O)H, --CO.sub.2 R.sub.1 l wherein R.sub.1 is hydrogen or C.sub.1 to C.sub.10 alkyl and --OCH.sub.2 PO.sub.3 H.sub.2, with the proviso that one of D or G is other than hydrogen or C.sub.1 to C.sub.10 alkyl; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 22, 1989Date of Patent: January 29, 1991Assignee: Abbott LaboratoriesInventors: Daniel W. Norbeck, Terry J. Rosen, Hing L. Sham
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Patent number: 4977277Abstract: The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; arylalkyl; OR.sub.8 or SR.sub.8 wherein R.sub.8 is hydrogen, loweralkyl or aminoalkyl; NR.sub.9 R.sub.10 wherein R.sub.9 and R.sub.10 are independently selected from hydrogen, loweralkyl, aminoalkyl, cyanoalkyl and hydroxyalkyl; ##STR2## wherein B is NH, alkylamino, S, O, CH.sub.2 or CHOH and R.sub.11 is loweralkyl, cycloalkyl, aryl, arylalkyl, alkoxy, alkenyloxy, hydroxyalkoxy, dihydroxyalkoxy, arylalkoxy, arylalkoxyalkyl, amino, alkylamino, dialkylamino, (hydroxyalkyl)(alkyl)amino, (dihydroxyalkyl)(alkyl)amino, carboxylic acid-substituted alkyl, alkoxycarbonylalkyl, aminoalkyl, N-protected aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, (N-protected)-(alkyl)aminoalkyl, (heterocyclic)alkyl or a substituted or unsubstituted heterocyclic; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, .alpha.-methylbenzyl, .alpha., .alpha.Type: GrantFiled: June 5, 1989Date of Patent: December 11, 1990Assignee: Abbott LaboratoriesInventors: Saul H. Rosenberg, Jay R. Luly, Jacob J. Plattner
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Patent number: 4971978Abstract: A compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are substituents; R.sub.6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O).sub.2 ; Ar is a heterocyclic group; and n is 1 to 3.Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.Type: GrantFiled: August 22, 1988Date of Patent: November 20, 1990Inventors: Alex M. Nadzan, James F. Kerwin, Chun W. Lin
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Patent number: 4970210Abstract: Pyridazinone, triazinone and oxapyridazinone compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.Type: GrantFiled: June 28, 1988Date of Patent: November 13, 1990Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, Anwer Basha, Bruce P. Gunn, Pramila A. Bhatia
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Patent number: 4962112Abstract: Naphthyridine and quinoline compounds having the formula: ##STR1## wherein A is CH or N; Z is an amine having the formula: ##STR2## R is o,p-difluorophenyl or p-fluorophenyl; and R.sub.1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.Type: GrantFiled: February 26, 1988Date of Patent: October 9, 1990Assignee: Abbott LaboratoriesInventors: Terry J. Rosen, Daniel T. Chu
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Patent number: 4956475Abstract: A process for the preparation of enantiomerically homogeneous aminopyrrolidinyl naphthyridine carboxylic acids and quinolone carboxylic acids, and for the preparation of intermediates that are useful in the production of these carboxylic acids.Type: GrantFiled: May 25, 1989Date of Patent: September 11, 1990Assignee: Abbott LaboratoriesInventors: Daniel T. Chu, Terry J. Rosen
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Patent number: 4927807Abstract: A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof.Type: GrantFiled: September 8, 1988Date of Patent: May 22, 1990Assignee: Abbott LaboratoriesInventors: Herman H. Stein, Jacob J. Pattner, Steven R. Crowley
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Patent number: 4921877Abstract: An improved nutritionally complete formula containing a unique fiber-containing carbohydrate blend, at a relatively low concentration; a unique fat blend, at a relatively high concentration; protein; carnitine; myoinositol; vitamins and minerals, including chromium. This formula is for the dietary management of patients with glucose intolerance.Type: GrantFiled: December 16, 1987Date of Patent: May 1, 1990Assignee: Abbott LaboratoriesInventors: Karen A. Cashmere, Elizabeth M. Besozzi
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Patent number: 4897256Abstract: The invention relates to novel solution and suspension aerosol formulations comprising LHRH analogs.Type: GrantFiled: November 4, 1987Date of Patent: January 30, 1990Assignee: Abbott LaboratoriesInventors: Akwete L. Adjei, Edwin S. Johnson, James W. Kesterson