Abstract: An improved device for containing and administering orally active therapeutic agents is described. A unit dose of a therapeutic agent in free-flowing form is retained and positioned for oral administration in a tube adapted to deliver the dose with a flow of liquid drawn through the tube by normal sipping action of a patient. The combination of small particle size and high flow rates into the alimentary canal allow dosage administration with minimal sensed contact with the oral cavity. The invention is particularly advantageous for the administration of orally active therapeutic agents to pediatric and geriatric patients.

Abstract: Uniform adherent coatings of antimicrobial agents are applied to the surface of implants by applying a film of silicone oil to the surface of the implant and then contacting the film-bearing surface with antimicrobial agents in a film-adherent powder form. A durable antimicrobial coating is formed. The coated implants can be packaged using mechanized implant handling equipment without significant loss of the antimicrobial coating.

Abstract: The presence of a sufficient amount of a calcium complexing agent prevents the gelling of corn steep liquor.

Abstract: A cold-water-swelling granular starch material derived from ungelatinized corn starch and characterized by a cold-water solubility of at least 50% is prepared by subjecting granular corn starch, slurried in selected aqueous alcohols, to conditions of high temperature and pressure. The cold-water-swelling granular starch material derived from chemically unmodified (or minimally modified) ungelatinized corn starch has an ability to set to a sliceable gel without cooking or chilling when blended with an aqueous sugar syrup. That granular starch material is particularly useful in food systems of the type which set or gel upon standing such as pie fillings, jellies, demouldable desserts and puddings.

Abstract: Hydroxypropylation of granular starch in a liquid medium comprising a lower alkanol under alkaline conditions in a confined zone at high temperature provides a novel improved hydroxypropyl substituted granular starch having a pasting temperature reduced from that of the granular starch before hydroxypropyl substitution by at least 6.5.degree. C. for each 1% by weight of hydroxypropyl substitution.

Abstract: A method of promoting growth and enhancing feed efficiency in meat producing animals. The 6' esters of zearalanol are effective growth promoting agents in meat producing animals, particularly ruminants, when implanted subcutaneously in said animals to obtain a controlled release of the compositions.Included in this group of compositions are: zearalanol 6'-butyrate; zearalanol 6'-decanoate; zearalanol 6'-hexanoate; zearalanol 6'-laurate; zearalanol 6'-trichloroacetate; and zearalanol 6'-trifluoroacetate.

Abstract: The "livering" or gelling of corn steep liquor or liquid products containing corn steep liquor is prevented or reversed by the addition of an effective amount of a calcium complexing agent, preferably at a pH of less than about 3.8.

Abstract: Certain novel bipyridine substituted imidazoylidene compounds, their metal complexes (Cu, Fe and Ni) which are effective to improve feed efficiency and promote growth in food-producing animals, particularly ruminants. The compounds are described by the general formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen, alkyl or phenyl, and including the cuprous, nickelous and ferrous salts thereof.

Abstract: Novel compositions of matter comprising the 6' esters of zearalanol which have utility as growth promoting agents in meat-producing animals, particularly ruminants. The compositions include: zearalanol 6'-butyrate; zearalanol 6'-decanoate; zearalanol 6'-hexanoate; zearalanol 6'-laurate; zearalanol 6'-trichloroacetate; and zearalanol 6'-trifluoroacetate.

Abstract: An adsorbable fibrin excipient for active biochemical agents which enables controlled release of the biochemical agents when a fibrin pellet or other article containing the biochemical agent is implanted in an animal. Also contemplated are formable combinations of fibrin and other materials, such as lactose, to vary the absorption rate from the rate obtained using fibrin alone.

Abstract: Novel oxazolinoazetidinone intermediates are prepared by cyclizing 2-chloroazetidinones with lead difluoride in dimethyl sulfoxide. The oxazolinoazetidinone products are useful as intermediates in the preparation of oxygen analogues of penicillins.

Abstract: The kinetically controlled products of the reaction of triaryl phosphites and bromine or chlorine are stabilized by the presence of tertiary amine bases or halide complexing reagents. The stabilized halogenating reagents are useful in the preparation of 3-halo-3-cephem antibiotic compounds.

Abstract: 4'-Nitrobenzyl 7-phenoxyacetamide-3-hydroxy-3-cephem-4-carboxylate forms crystalline solvates with acetic acid, propionic acid and methylene chloride. The corresponding 3-hydroxy-3-cephem sulfoxide forms crystalline solvates with acetic acid, propionic acid and methanol. The described solvates allow for facile isolation and purification of 4'-nitrobenzyl 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate and its 1-oxide.

Abstract: Novel halogenating agents are derived from triaryl phosphites and chlorine or bromine. They are useful in converting 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives.

Abstract: Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives. The product 3-halo-3-cephems are antibiotic compounds or intermediates thereto.

Abstract: Cephalosporin sulfoxides are reduced to the corresponding cephalosporins in the presence of a halogen scavenger with triaryl phosphite-halogen complexes derived from the kinetically controlled reaction of selected triaryl phosphites and chlorine or bromine.

Abstract: Penicillin and cephalosporin imino halides are prepared by reacting of 6-acylaminopenicillins or 7-acylamino cephalosporins with a novel chlorinating compound derived from a triaryl phosphite and chlorine or bromine. The imino halide products are intermediates in the preparation of antibiotic compounds.

Abstract: Cephalosporin compounds of the formula ##STR1## wherein R and R.sub.2 are hydrogen or protecting groups, R.sub.1 is hydrogen or methoxy, R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sub.4 is C.sub.1 -C.sub.4 alkyl, are broad spectrum antibiotics or intermediates thereto.

Abstract: Novel 3-acylaminoazetidin-4-one antibiotic compounds, prepared by reduction of known 2-chloroazetidin-4-one compounds with tri(butyl)tin hydride, are antinicrobial agents.

Abstract: 3-Exomethylenecepham sulfoxides are prepared by the reaction of 3-methyl-3-halocepham sulfoxides with mercuric or mercurous perchlorate.