Abstract: Novel stereoisomers of GS-164 are provided. The compounds, such as (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH-237A) and (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH-242A) exhibit neuroprotective effects via a mechanism that does not involve microtubule stabilization.
Type:
Grant
Filed:
November 1, 2006
Date of Patent:
October 6, 2009
Assignee:
University of Kansas
Inventors:
Mary Louise Michaelis, Ingrid Gunda Georg, Richard H. Himes, Kenneth L. Audus