Patents Represented by Attorney Stuart D. Frenkel
  • Patent number: 6395067
    Abstract: Porous titanium silicate molecular sieves are produced in the form of a membrane capable of separating fluid molecular mixtures.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: May 28, 2002
    Assignee: Engelhard Corporation
    Inventors: Steven M. Kuznicki, Valerie A. Bell, Richard M. Jacubinas
  • Patent number: 6387159
    Abstract: A process for adsorbing hydrocarbons from an acid gas stream includes passing the acid gas stream through an adsorbent which selectively removes hydrocarbons, desorbing the hydrocarbons from the adsorbent and contacting the desorbed hydrocarbons with an acid gas removal solution to remove acid gases which have been coadsorbed with the hydrocarbons. The process is particularly useful in removing hydrocarbons from a hydrogen sulfide-containing stream which is being directed to Claus processing for conversion into elemental sulfur. Useful adsorbents include crystalline titanium silicate molecular sieves containing titania octahedral sites such as ETS-10 and similar materials, as well as high silica aluminosilicate zeolite.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: May 14, 2002
    Assignee: Engelhard Corporation
    Inventors: Kenneth F. Butwell, William B. Dolan, Steven M. Kuznicki
  • Patent number: 6376543
    Abstract: The present invention relates to a secondary cataract inhibitor comprising as the active ingredient N-(3,4-dimethoxy-cinnamoyl)anthranilic acid represented by the formula: or a pharmaceutically acceptable salt thereof, which has an inhibitory activity on posterior capsule opacification formation after cataract surgery and is useful for the prevention or treatment of secondary cataract.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: April 23, 2002
    Assignee: Kissei Pharmaceuticals Co., Ltd.
    Inventors: Masayuki Isaji, Hiroshi Miyata, Yukiyoshi Ajisawa
  • Patent number: 6376513
    Abstract: The present invention relates to a novel drug method for relieving pain and promoting the removal of calculi in urolithiasis which contains an active ingredient having stimulating effects on both &bgr;2- and &bgr;3-adrenoceptors and exerting a potent relaxing effect on human ureteral smooth muscle.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: April 23, 2002
    Assignee: Kissei Pharmaceuticals Co., Ltd.
    Inventors: Masuo Akahane, Yoshitaka Tomiyama
  • Patent number: 6337076
    Abstract: A method and composition for treating hypertrophic scars so as to reduce the size and approve the appearance of scars comprises applying to the scar a composition comprising a film-forming carrier such as a Collodion which contains one or more active ingredients such as a topical steroid, silicone gel and vitamin E. Novel compositions using the Collodion film-forming carrier are also useful to treat a variety of adverse skin disorders.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: January 8, 2002
    Assignee: SG Licensing Corporation
    Inventor: Joel R. Studin
  • Patent number: 6315817
    Abstract: A pressure swing adsorption process for the separation of hydrogen from a mixture of the same with methane, utilizing two separate PSA stages, one containing a nitrogen selective crystalline zeolite, and the second containing a methane selective adsorbent.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: November 13, 2001
    Assignee: Engelhard Corp.
    Inventors: Kenneth F. Butwell, William B. Dolan, Steven M. Kuznicki
  • Patent number: 6310086
    Abstract: The present invention relates to indole derivatives represented by the general formula: (wherein R represents an ethyl group or a 2,2,2-trifluoroethyl group; Y represents a hydroxy group or a pivaloyloxy group; and the carbon atom marked with (R) represents a carbon atom in (R) configuration) and pharmaceutically acceptable salts thereof, which have potent and prolonged reducing effects on intraocular pressure and are useful as agents for lowering intraocular pressure.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: October 30, 2001
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Makio Kitazawa, Toshiaki Yamaguchi, Hiroshi Miyata, Yukiyoshi Ajisawa
  • Patent number: 6303104
    Abstract: An oral product, preferably a toothpaste, effective for remineralizing subsurface dental lesions, mineralizing exposed dentinal tubules and whitening teeth stained with discoloring residues containing heavy metal ions such as Fe+3, Mn+2 and Cu+2, is composed of a first discrete part composed of a water-soluble or partially water-soluble calcium salt and optionally a non-toxic, non-calcium water-soluble divalent metal salt, and a second discrete part composed of a water-soluble orthophosphate salt and preferably a water-soluble fluoride salt. Further enhanced stain-removing properties without excessive abrasivity are imparted to the oral product when part (A) further contains an effective amount of an anhydrous dicalcium phosphate abrasive and part (B) further contains an effective amount of a silica abrasive.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: October 16, 2001
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Jordan Barth, Norman Usen
  • Patent number: 6303655
    Abstract: The present invention relates to an agent for the prevention or treatment of diseases associated with excessive proliferation of retinal pigment epithelial cells such as proliferative vitreoretinopathy comprising as the active ingredient N-(3,4-dimethoxycinnamoyl)anthranilic acid represented by the formula: or a pharmaceutically acceptable salt thereof, which has an inhibitory activity on proliferation of retinal pigment epithelial cells.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: October 16, 2001
    Assignee: Kissei Pharmaceutical Co., Ltd.
    Inventors: Yasuo Takehana, Makio Kitazawa
  • Patent number: 6210621
    Abstract: A plural-chambered dispensing tube is made by a method involving molding a molten resin material into a tube head while a pre-finished tube body having a partition disposed therein is disposed within the molten resin material. Thus, the pre-finished tube body and partition become connected to the tube head as the latter is being molded. In this way, the tube body and the partition are molded into the tube head to form a uniform seal between the partition and the tube head and to improve the separation of the stored components.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: April 3, 2001
    Assignee: Enamelon, Inc.
    Inventors: Norman Usen, Thomas J. Duncan
  • Patent number: 6180673
    Abstract: The present invention relates to a corneal subepithelial opacity (haze) inhibitor comprising as the active ingredient N-(3,4-dimethoxycinnamoyl)anthranilic acid represented by the formula: or a pharmaceutically acceptable salt thereof, is useful for the prevention or treatment of corneal subepithelial opacity (haze) caused by a wound during the operation of refractive surgery such as keratectomy and radial keratotomy, and an external wound.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: January 30, 2001
    Assignees: Kissei Pharmaceutical Co., Ltd., Nihon Tenganyaku Co., Ltd.
    Inventors: Yoichi Iwaki, Ikuo Tobari, Susumu Okamoto, Tatsuro Sakai
  • Patent number: 6159448
    Abstract: Improved one-part and two-part liquid products such as, e.g., mouthwashes, mouthrinses, toothpastes, gels and the like, for remineralizing subsurface lesions and/or mineralizing exposed dentin tubules in teeth contain a cationic component, an anionic component and a separating means for separating the cationic and anionic components. The anionic component contains water-soluble phosphate and fluoride salts, while the cationic component contains at least one partially water-soluble calcium salt and preferably at least one water-soluble salt of a divalent metal other than calcium. The tooth is treated with a mixed aqueous composition formed by mixing the cationic and anionic components with water and/or saliva. The mixed aqueous composition has a pH of from about 4.0 to about 10.0 and, in addition to dissolved calcium cations and dissolved phosphate and fluoride anions, contains a quantity of undissolved calcium salt.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: December 12, 2000
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: 6159449
    Abstract: A dentifrice product substantially free of water-soluble inorganic orthophosphates and capable of remineralizing subsurface lesions and/or mineralizing exposed dentinal tubules in teeth, contains (A) a discrete cationic part containing at least one water-soluble and/or partially water-soluble calcium compound and a fluoride-protecting amount of at least one water-soluble and/or partially water-soluble magnesium compound, and (B) a discrete anionic part containing at least one water-soluble fluoride compound. The cationic and anionic parts are disposed separate from one another in the product and are simultaneously releasable from the product. The cationic and anionic parts each have a pH in water such that a mixed aqueous composition formed by mixing the cationic and anionic parts with (i) saliva or (ii) water and saliva has a pH of from about 4.0 to about 10.0. The mixed aqueous composition simultaneously applies the cationic and anionic parts to the tooth surfaces being treated.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: December 12, 2000
    Assignee: Enamelon, Inc.
    Inventors: Anthony E. Winston, Norman Usen
  • Patent number: 6077836
    Abstract: A peritoneal dialysis composition containing an osmotic agent comprising a glucose polymer mixture, said mixture including at least 15% by weight of glucose polymers having a D.P. (degree of polymerization) greater than 12. A method is provided for preparing the glucose polymers and a defined sterile aqueous solution of the same for use in peritoneal dialysis by introduction into the abdominal cavity. Also disclosed are methods of treating toxaemia caused by toxins arising from internal disorders of the body, such as hepatic encephalopathy, or which arise from external sources such as poisoning by overdoses of drugs or industrial and agricultural chemicals, e.g., paraquat.
    Type: Grant
    Filed: December 9, 1992
    Date of Patent: June 20, 2000
    Assignee: ML Laboratotries, PLC
    Inventor: Jeremiah Milner
  • Patent number: 5869026
    Abstract: Novel ligands for use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.1 -R.sub.14, M", l, m, and n are defined herein.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: February 9, 1999
    Assignee: Hoechst Celanese Corp.
    Inventors: Wei-Jen Peng, David E. Reichert
  • Patent number: 5869025
    Abstract: A composition of matter having the formula ##STR1## wherein R.sub.1 -R.sub.14, M, l, m, and n are defined herein and which have application as MRI contrasting agents.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: February 9, 1999
    Assignees: Hoechst Celanese Corporation, Washington University
    Inventors: Wei-Jen Peng, David E. Reichert
  • Patent number: 5861138
    Abstract: Novel ligands for use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.1 -R.sub.14, M", l, m, and n are defined herein.
    Type: Grant
    Filed: November 20, 1996
    Date of Patent: January 19, 1999
    Assignee: Hoechst Celanese Corp.
    Inventors: Wei-Jun Peng, Daniel A. Aguilar
  • Patent number: 5861140
    Abstract: A composition of matter having the formula ##STR1## wherein R.sub.1 -R.sub.14, M, l, m, and n are defined herein and which have application as MRI contrasting agents.
    Type: Grant
    Filed: November 20, 1996
    Date of Patent: January 19, 1999
    Assignee: Hoechst Celanese Corp.
    Inventors: Wei-Jun Peng, Daniel A. Aguilar
  • Patent number: 5824288
    Abstract: Novel precursors of ligands or use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.2-R.sub.10 are defined herein.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: October 20, 1998
    Assignee: Hoechst Celanese Corporation
    Inventors: Wei-Jen Peng, Humberto Ramos, Jr., Daniel A. Aguilar
  • Patent number: 5820851
    Abstract: A composition of matter having the following ##STR1## wherein R, R.sub.1 -R.sub.10 and M are defined herein.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: October 13, 1998
    Assignee: Hoechst Celanese Corporation
    Inventors: Wei-Jen Peng, Humberto Ramos, Jr.