Patents Represented by Attorney Susan A. Capello
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Patent number: 6014904Abstract: A method for automatically classifying multi-parameter data into cluster groups for the purpose of defining different populations of particles in a sample by automatically defining a position of at least one variable position, geometric boundary surface on a two-dimensional scatter plot so as to enclose a group of the displayed particles in a data cluster; with the boundary surface having a polygonal shape defined by a plurality of vertices about at least one cell cluster created by building at least one histogram from cross sections of the two-dimensional scatter plot. Preferably, each cross section of the geometric boundary includes a rectangular, two dimensional gate. The method is particularly useful in the field of cellular analysis using, for example, flow cytometers wherein multi-parameter data is recorded for each cell that passes through an illumination and sensing region.Type: GrantFiled: October 27, 1997Date of Patent: January 18, 2000Assignee: Becton, Dickinson and CompanyInventor: Michael D. Lock
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Patent number: 6008052Abstract: Cells fixed with a fixative, reduced with a Schiff's base reducing agent and then dried in the presence of .alpha.-.alpha.-trehalose retain their light scatter and fluorescence properties and may be used, when rehydrated, as standards or controls in cellular analysis.Type: GrantFiled: June 10, 1992Date of Patent: December 28, 1999Assignee: Becton, Dickinson & CompanyInventors: Kenneth A. Davis, Anthony J. Ward
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Patent number: 5954684Abstract: An iontophoretic drug delivery device of the present invention includes a power source and an electrode assembly containing at least two electrodes, in electrical contact with a first reservoir and a second reservoir. The present invention also includes at least three electrodes in a three electrode embodiment, with the third electrode in electrical contact with a third reservoir. In either embodiment, the first reservoir and the second reservoir contain an active agent to be delivered to an applied area of a patient. The present invention also includes in its two electrode embodiment a switch for reversing the flow of current or in its three electrode embodiment a switch for switching the flow of current, so as to reduce sensation. The devices also include a timer for controlling the amount of time the electrical current flows in each direction.Type: GrantFiled: October 11, 1995Date of Patent: September 21, 1999Assignee: Becton Dickinson and CompanyInventors: Ronald J. Flower, Burton H. Sage, Jr.
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Patent number: 5899876Abstract: An apparatus and method of delivering drugs from multiple sites on a patients body is provided. A controller is used at each site, and these controllers communicate with each other to coordinate drug delivery from the multiple sites. In a preferred embodiment, the drugs are delivered using iontophoresis.Type: GrantFiled: August 27, 1997Date of Patent: May 4, 1999Assignee: Becton, Dickinson and CompanyInventor: Ronald J. Flower
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Patent number: 5882677Abstract: An improved hydrogel reservoir for use in two-compartment iontophoretic patches is described. The hydrogel reservoir contains a water soluble polyelectrolyte and a fluid. The reservoir may also contain a matrix forming material such as polyvinylpyrrolidone. A preferred water-soluble polyelectrolyte is sodium polystyrene sulfonate.Type: GrantFiled: September 30, 1997Date of Patent: March 16, 1999Assignee: Becton Dickinson and CompanyInventor: Gary B. Kupperblatt
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Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation
Patent number: 5880474Abstract: A multi-laser flow-cytometry system provides for inter-location emissions crosstalk cancellation, through either pulse subtraction or gating, to avoid false triggering based on shadow (pre- and post-) pulses that occur when red-excited red emissions are detected by a photodetector arranged to detect blue-excited red emissions. This overcomes a problem of undercounting of counting beads that led to misdeterminations of cell counts when blue-excited red fluorescence detections were used as a trigger. The approach also provides for more accurate quantitative data regarding fluorochrome emissions amplitudes.Type: GrantFiled: August 29, 1997Date of Patent: March 9, 1999Assignee: Becton Dickinson and CompanyInventors: Pierce Owen Norton, Robert A. Hoffman -
Patent number: 5843015Abstract: The present invention relates to a method for preparing proteins or peptides for iontophoretic delivery by modifying said proteins or peptides, by hydrophobic bonding of acharged molecule to a hydrophobic region of the protein or peptide, to have an isoelectric point of less than about 4.0 or greater than about 7.3 with an electrostatic charge of at least plus or minus 1 over the pH range of about 4.0 to about 7.3. Another embodiment of the present invention relates to a device for delivery of a protein or peptide having an isoelectric point of less than about 4.0 or greater than about 7.3 with an electrostatic charge of at least plus or minus 1 over the pH range of about 4.0 to about 7.3.Type: GrantFiled: February 10, 1997Date of Patent: December 1, 1998Assignee: Becton Dickinson and CompanyInventors: Burton H. Sage, Jr., Randal A. Hoke
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Patent number: 5840580Abstract: One or more population of cells enriched for human hematopoietic stem cells is disclosed. HSC in this population of cells are capable of limited self-renewal and are capable of differentiating into all elements of the hematopoietic system. This population of cells has the phenotype of CD34.sup.+ /CD38.sup.- and more preferably CD34.sup.+ /CD38.sup.- /HLA-DR.sup.+. Cells within this population have been found to express CD13, CD33 and CD71. Hematopoietic stem cells can be used in a number of therapies, including autologous transplantation and in gene therapy.Type: GrantFiled: May 14, 1997Date of Patent: November 24, 1998Assignee: Becton Dickinson and CompanyInventors: Leon W. Terstappen, Michael R. Loken, Shiang Huang, Johanna Olweus, Fridtjof Lund-Johansen
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Patent number: 5830175Abstract: An iontophoretic drug delivery system of the present invention includes a disposable patch electrically interconnectible with a controller. The patch includes at least two electrode assemblies, with one of the electrode assemblies having a first electrode and a second electrode. In this way, during delivery of electrical current one of the electrodes is exhausted so that upon an attempt to reuse the patch, the controller does not detect the delivery of electrical current through said electrodes and fails to supply electrical current to the electrode assemblies for delivery of the drug. Electrical interconnection between the patch and the controller is established by inserting a tab extending from the patch into the controller.Type: GrantFiled: July 24, 1997Date of Patent: November 3, 1998Assignee: Becton Dickinson and CompanyInventor: Ronald J. Flower
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Patent number: 5828198Abstract: The apparatus includes a combination of a microscope and an interactive image analysis system comprising a camera and a computer work station. The purpose of the apparatus is to facilitate the interactive control of coordinate displacements of the stage of the microscope. For each coordinate x and y an electromechanical control channel is established. At the input of the control channel two cascaded wheels in a coaxial arrangement and two angle encoders are used as a detached, independent tool which is not kinematically linked to the stage. In the middle of the control channel, the pulses of the angle encoders undergo a non-linear transformation. A processor performs a calculation which discriminates between slow displacements and fast displacements. At the end of the control channel, a flat, easily accessible platform of the microscope stage has two working areas, one for manual previewing and one for interactive scanning of a specimen.Type: GrantFiled: May 6, 1997Date of Patent: October 27, 1998Assignee: Becton Dickinson and CompanyInventors: Peter Den Engelse, Alexander Flipse, Walter Janus
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Patent number: 5817044Abstract: A user activated iontophoretic device of the present invention includes an electrode assembly, an electrode reservoir and at least one drug reservoir. The device is divided or otherwise separated into at least two portions, with one portion containing the electrode reservoir and the other containing the drug reservoir, which may include a medication in a dry form. In one embodiment, the two portions are each contained in separate compartments of a pouch. In another embodiment, the portions are contained in a single compartment and divided by a barrier. A method of activating the device includes causing the two portions to come into electrical conducting contact with one another to at least partially hydrate one of the reservoirs. This can be accomplished, for example, by either folding the device to bring the two portions into contact with one another or simply by removing the barrier dividing the two portions.Type: GrantFiled: July 28, 1994Date of Patent: October 6, 1998Assignee: Becton Dickenson and CompanyInventors: Hans Christer Arvid Evers, Bernt Fredrick Julius Broberg, John D. DeNuzzio, Randal A. Hoke
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Patent number: 5792097Abstract: The present invention relates to improving the utilization of the active mass of printed ink electrodes by adding a surface active agent to at least one of the following the printed ink formulation, the gel formulation, the electrolyte reservoir or the medicament formulation.Type: GrantFiled: September 27, 1996Date of Patent: August 11, 1998Assignee: Becton Dickinson and CompanyInventor: Vilambi Nrk Reddy
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Patent number: 5788863Abstract: The present invention relates to an apparatus and method for conducting an assay using reverse flow through a membrane. More particularly, the present invention is directed to an apparatus and method which allows for the assaying of analytes, such as antigens, in a fluid sample containing such analytes with more accurate and reproducible results.Type: GrantFiled: December 13, 1995Date of Patent: August 4, 1998Assignee: Becton Dickinson and CompanyInventor: David Milunic
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Patent number: 5776709Abstract: A method of flow cytometric analysis of leukocyte subpopulations using a fluorescence trigger and gating on light scatter vs. fluorescence. The methods are useful where light scatter parameters are unsatisfactory for identification of leukocyte subpopulations, for example when analyzing lysed blood samples without removal of lysing reagent or unbound label prior to analysis.Type: GrantFiled: August 4, 1994Date of Patent: July 7, 1998Assignee: Becton Dickinson and CompanyInventors: Anne Louise Jackson, Robert Alan Hoffman, Andrew D. Blidy, Kenneth Earl Murchison, Pierre Bierre, Dan E. Thiel
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Patent number: 5735810Abstract: The present invention relates to a method and device for the iontophoretic delivery of a therapeutic dose range of bisphosphonate to be delivered to a patient over a period of lime to prevent the onset for advancement of osteoporosis and other metabolic bone diseases for a selected period of time.Type: GrantFiled: September 4, 1996Date of Patent: April 7, 1998Assignee: Becton Dickinson and CompanyInventors: Burton H. Sage, Jr., Philip G. Green
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Patent number: 5730715Abstract: A method for preventing the onset or advancement of osteoporosis or other metabolic bone disorders in a patient by iontophoretically administering to the patient an effective amount of a bisphosphonate which would be effective for preventing the onset or advancement of osteoporosis or other bone disorders and wherein the effective amount of bisphosphonate is delivered over a period of from about four (4) hours to about forty-eight (48) hours, at intervals of from about once a week to about twice a year and wherein the effective amount of bisphosphonate also contains an agent capable of chelating calcium.Type: GrantFiled: June 14, 1996Date of Patent: March 24, 1998Assignee: Becton Dickinson and CompanyInventors: Burton H. Sage, Jr., Philip G. Green
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Patent number: 5716798Abstract: This invention describes a method for the rapid identification of the presence of microorganisms in a sample. Briefly, in the method of this invention the sample container is divided into a plurality of discrete zones, each of which can be separately monitored for microbial presence. When a sample is placed into this container, detection is simplified as the volume monitored is low (as compared with the sample); since microbial detection is a concentration dependent phenomenon, the speed with which the presence of microbial contamination can be detected is increased.Type: GrantFiled: September 22, 1992Date of Patent: February 10, 1998Assignee: Becton Dickinson and CompanyInventors: James F. Monthony, David T. Stitt, Denise H. Burroughs
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Patent number: 5710043Abstract: An assembly for in vitro culture of cells of the present invention includes a culture vessel with at least one well. The well has an open top, a bottom and a wall with an inside surface. The assembly also includes at least one insert sized for placement within the well. The insert has an outside surface, an open end and a closed end. There is a microporous membrane at the closed end of the insert that closes the end and thereby forms a receptacle within the inset. The assembly further includes provisions for adjustably positioning the insert within the well between a first position where the closed end of the insert is a first distance from said bottom of the well and a second position where the closed end of the insert is a second distance from the well bottom.Type: GrantFiled: September 25, 1995Date of Patent: January 20, 1998Assignee: Becton Dickinson and CompanyInventor: Nicholas George Martin Pay
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Patent number: 5681743Abstract: A well plate assembly useful for laboratory-scale cell culture and diagnostic tests of the present invention includes a substantially planar base with at least one well and a top surface. A lid is joined to the base by a hinge as part of the assembly. The hinge allows the lid to be moved between a closed position, where the lid covers the top surface, and a plurality of open positions where the top surface is uncovered. The assembly includes provisions for releasably retaining the lid in the closed and plurality of open positions.Type: GrantFiled: July 20, 1995Date of Patent: October 28, 1997Assignee: Becton Dickinson and CompanyInventors: Barry B. Brian, Larry A. Franchere
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Patent number: D395392Type: GrantFiled: September 26, 1996Date of Patent: June 23, 1998Assignee: Becton Dickinson and CompanyInventors: William J. Lahm, Stephen C. Conley