Patents Represented by Attorney Susan H. Rauch
  • Patent number: 4723011
    Abstract: Pyridine-2,3-dicarboxylates of Formula I ##STR1## are prepared by reacting an alpha halo-beta keto ester of formula II ##STR2## with an alpha, beta-unsaturated aldehyde or ketone of formula III ##STR3## in the presence of a minimum of 2 molar equivalents of ammonium salt.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: February 2, 1988
    Assignee: American Cyanamid Company
    Inventor: Robert F. Doehner, Jr.
  • Patent number: 4698092
    Abstract: The present invention relates to novel herbicidal pyridinium inner salts and ylides, methods for their preparation and a method for controlling undesirable vegetation utilizing said compounds.
    Type: Grant
    Filed: January 24, 1986
    Date of Patent: October 6, 1987
    Assignee: American Cynamid Company
    Inventor: Marinus Los
  • Patent number: 4689324
    Abstract: Novel 10,10-Dihydro-10-[(substituted carbonyl)imino]-10-phenyl-10H-phenoxaphines of the formula: ##STR1## wherein A is selected from the group consisting of hydrogen and COOR.sub.1, where, when A is hydrogen the compound is in the form of a water soluble salt HnX, where n is an integer 1 or 2 and X is selected from the group consisting of sulfate, trefluoroacetate, bromide and chloride and R.sub.1 is selected from the group consisting of straight or branched chain alkyl(C.sub.1 -C.sub.4), alkenyl(C.sub.2 -C.sub.4), alkynyl(C.sub.2 -C.sub.4), cycloalkyl(C.sub.3 -C.sub.6), cycloalkyl(C.sub.3 -C.sub.6)methyl, benzyl, pyridylmethyl or which tetrahydro-3-furanyl; methods for using these compounds for effecting diuresis, treating hypertension and edema and lowering plasma renin activity in mammals; pharmaceutical compositions of matter containing these compounds and processes for their preparation.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: August 25, 1987
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, Joseph W. Marsico, Nancy H. Eudy, Howard Newman
  • Patent number: 4684654
    Abstract: Compounds of the formula: ##STR1## wherein A is a divalent moiety of the formula:--C.sub.n H.sub.2n -- --CH.sub.2 CH.dbd.CHCH.sub.2 --or ##STR2## wherein n is an integer from 2-10, inclusive; R is hydrogen or alkyl having from one to four carbon atoms; R.sub.1 and R.sub.2 may be the same or different and may be selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkoxy having from one to four carbon atoms, alkyl having from one to four carbon atoms, nitro and amino; wherein Heteroaryl is ##STR3## wherein R.sub.3 and R.sub.4 may be selected from hydrogen, alkyl having from one to four carbon atoms, or phenyl; and X is CH or N, together with the pharmaceutically acceptable salts thereof, which act as thromboxane synthetase inhibitors and hypotensive agents; methods for their production and use.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: August 4, 1987
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik
  • Patent number: 4680293
    Abstract: Novel 3-heteroarylalkyl-1,2,3-benzotriazin-4(3H)-ones, having the structural formula: ##STR1## wherein A is a divalent moiety of the formula: ##STR2## wherein n is an integer from 3 to 10, inclusive; R.sub.1 and R.sub.2 may be the same or different and may be selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkoxy having from one to four carbon atoms, alkyl having from one to four carbon atoms, nitro and amino; wherein Heteroaryl is ##STR3## wherein R.sub.3 and R.sub.4 may be hydrogen, alkyl having from one to four carbon atoms or phenyl and X is CH or N; together with the pharmaceutically acceptable salts thereof; processes for their preparation and their use in treating prostaglandin-related vascular disorders including ischemic heart disease, transient ischemic attack, thrombosis, migraine and hypertension.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: July 14, 1987
    Assignee: American Cyanamid Company
    Inventors: William B. Wright, Jr., Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
  • Patent number: 4675336
    Abstract: Novel organic compounds of the formula ##STR1## Where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and method of using the compounds to treat tumors in mammals.
    Type: Grant
    Filed: June 26, 1985
    Date of Patent: June 23, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Patent number: 4657912
    Abstract: The invention is pesticidal granular bait compositions useful for the control of ants and a method of controlling ants using the composition.
    Type: Grant
    Filed: March 18, 1986
    Date of Patent: April 14, 1987
    Assignee: American Cyanamid Company
    Inventors: Munehiro Suzuki, Masaomi Kimpara, Kiyoshi Tsuda
  • Patent number: 4654347
    Abstract: Novel aryl and heteroaryl[7-(3-substituted amino phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]methanones useful as anxiolytic, antiepileptic and sedative-hypnotic agents and as skeletal muscle relaxants, methods of using the novel compounds, compositions containing them and processes for this production.
    Type: Grant
    Filed: May 13, 1985
    Date of Patent: March 31, 1987
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Andrew S. Tomcufcik, Jay D. Albright
  • Patent number: 4654343
    Abstract: Novel organic compounds which are N-substituted-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides , carbamates and ureas which are useful as anxiolytic or antiepileptic agents, methods of using the compounds, compositions of matter containing them as the active ingredient and processes for their production.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: March 31, 1987
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Dennis W. Powell, John P. Dusza
  • Patent number: 4650765
    Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
    Type: Grant
    Filed: July 30, 1985
    Date of Patent: March 17, 1987
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Amedeo A. Fantini, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Patent number: 4626538
    Abstract: Novel [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines useful as anxiolytic, antiepileptic and sedative-hypnotic agents as well as skeletal muscle relaxants, methods of using these compounds, compositions of matter containing them and processes for their production.
    Type: Grant
    Filed: May 13, 1985
    Date of Patent: December 2, 1986
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Andrew S. Tomcufcik, Jay D. Albright
  • Patent number: 4622401
    Abstract: This invention relates to novel 3-amino-1-heteroaryl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.
    Type: Grant
    Filed: September 19, 1984
    Date of Patent: November 11, 1986
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Joseph P. Joseph, Seymour Bernstein
  • Patent number: 4617319
    Abstract: A method of treating neuroimmunologic diseases such as multiple sclerosis and acute disseminated encephalomyelitis using 1,4-dihydroxy-5,8-bis[[(2-hydroxyethylamino)ethyl]amino]anthraquinone, or a pharmacologically acceptable acid addition salt thereof.
    Type: Grant
    Filed: June 13, 1985
    Date of Patent: October 14, 1986
    Assignee: American Cyanamid Company
    Inventors: Suresh S. Kerwar, Adolph E. Sloboda, Susan C. Ridge
  • Patent number: 4608205
    Abstract: Polyanionic benzene ureas and salts thereof useful as complement inhibitors.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: August 26, 1986
    Assignee: American Cyanamid Company
    Inventors: Ransom B. Conrow, Seymour Bernstein
  • Patent number: 4608343
    Abstract: This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: August 26, 1986
    Assignee: American Cyanamid Company
    Inventors: David P. Labeda, Joseph J. Goodman, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Patent number: 4599203
    Abstract: Multisulfonated naphthalene ureas, useful as complement inhibitors.
    Type: Grant
    Filed: March 28, 1984
    Date of Patent: July 8, 1986
    Assignee: American Cyanamid Company
    Inventors: Ransom B. Conrow, Seymour Bernstein
  • Patent number: 4591604
    Abstract: A method of inhibiting the complement system using multisulfonated naphthalene ureas.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: May 27, 1986
    Assignee: American Cyanamid Company
    Inventors: Ransom B. Conrow, Seymour Bernstein
  • Patent number: 4578468
    Abstract: Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: March 25, 1986
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Donald B. Borders, Joseph J. Goodman, David P. Labeda
  • Patent number: 4568646
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: January 24, 1985
    Date of Patent: February 4, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Patent number: 4552867
    Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: November 12, 1985
    Assignee: American Cyanamid Company
    Inventors: John H. E. J. Martin, Jane P. Kirby, Donald B. Borders, Amedeo A. Fantini, Raymond T. Testa