Patents Represented by Attorney Susan L. Steele

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  • Indazole inhibitors of kinase
    Patent number: 8293738
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A1, A2, A3 and L are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora and KDR.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: October 23, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Michaelides, James H. Holms, Douglas H. Steinman
  • Thienopyridine and furopyridine kinase inhibitors
    Patent number: 8273736
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: September 25, 2012
    Assignee: Abbott Laboratories
    Inventors: Patrick Betschmann, Andrew F. Burchat, David J. Calderwood, Michael L. Curtin, Steven K. Davidsen, Heather M. Davis, Robin R. Frey, Howard R. Heyman, Gavin C. Hirst, Peter Hrnciar, Michael R. Michaelides, Melanie A. Muckey, Kelly D. Mullen, Paul Rafferty, Carol K. Wada
  • 2-substituted-1H-benzimidazole-4-carboxamides are PARP inhibitors
    Patent number: 8217070
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: July 10, 2012
    Assignee: Abbott Laboratories
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • Potent PARP inhibitors
    Patent number: 8183250
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: May 22, 2012
    Assignee: Abbott Laboratories
    Inventors: Thomas D. Penning, Sheela A. Thomas, Philip J. Hajduk, Daryl R. Sauer, Kathy Sarris, Vincent L. Giranda
  • Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics
    Patent number: 8148384
    Abstract: Compounds of formula I wherein A1, A2, and A3 are as defined herein are inhibitors of PIM kinase. The compounds of formula I are useful for the treatment of diseases such as cancer.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: April 3, 2012
    Assignee: Abbott Laboratories
    Inventors: Thomas D. Penning, Lisa A. Hasvold, Laura A. Hexamer, Vincent L. Giranda, Nan-horng Lin, Zhi-Fu Tao, Le Wang
  • Poly(ADP-ribose)polymerase inhibitors
    Patent number: 8143284
    Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: March 27, 2012
    Assignee: Abbott Laboratories
    Inventors: Virajkumar B. Gandhi, Vincent Louis Giranda, Thomas D. Penning, Gui-Dong Zhu
  • Inhibitors of protein kinases
    Patent number: 8124759
    Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: February 28, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Michaelides, Zhiqin Ji
  • Inhibitors of protein kinases
    Patent number: 8110572
    Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: February 7, 2012
    Assignee: Abbott Laboratories
    Inventors: Yujia Dai, Zhiqin Ji, Michael R. Michaelides
  • Benzthiazole inhibitors of poly(ADP-ribose)polymerase
    Patent number: 8093396
    Abstract: Inhibitors of poly(ADP-ribose)polymerase having a structure of Formula (I), ways to make them and methods of treating patients using them are disclosed.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: January 10, 2012
    Assignee: Abbott Laboratories
    Inventors: Magdalena K. Przytulinska, Thomas D. Penning, Yunsong Tong
  • Protein kinase inhibitors
    Patent number: 8067409
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: November 29, 2011
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. Ba-Maung, Randy L. Bell, Richard F. Clark, Scott A. Erickson, Steve D. Fidanze, Robert D. Hubbard, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang, Jieyi Wang
  • Benzimidazole poly(ADP ribose)polymerase inhibitors
    Patent number: 8067613
    Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: November 29, 2011
    Assignee: Abbott Laboratories
    Inventors: Virajkumar B. Gandhi, Vincent L. Giranda, Jianchun Gong, Thomas D Penning, Gui-Dong Zhu
  • 2-{(R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 2
    Patent number: 8013168
    Abstract: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide Crystalline Form 2, ways to make it, compositions comprising it and made using it, and methods of treating patients having disease using it are disclosed.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: September 6, 2011
    Assignee: Abbott Laboratories
    Inventor: Gui-Dong Zhu
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7999117
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: August 16, 2011
    Inventors: Vincent L. Giranda, Thomas D. Penning, Virajkumar B. Gandhi, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong
  • Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases
    Patent number: 7956185
    Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: June 7, 2011
    Assignee: Abbott Laboratories
    Inventors: Robert B. Diebold, Stevan W. Djuric, Vincent L. Giranda, Laura A. Hexamer, Nan-Horng Lin, Julie M. Miyashiro, Thomas D. Penning, Magdalena Przytulinska, Thomas J. Sowin, Gerard M. Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith W. Woods, Zhiren Xia, Henry Q. Zhang
  • Pyrroloquinoxalinone inhibitors of poly(ADP-ribose)polymerase
    Patent number: 7790721
    Abstract: Compounds of formula I where X is a bond; A1 and A2, together with the atoms to which they are attached, is pyrrole; and A3 and A4, together with the atoms to which they are attached, are benzene; are poly(ADP-ribose)polymerase inhibitors. The compounds of formula I are useful for the treatment of diseases such as cancer.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: September 7, 2010
    Assignee: Abbott Laboratories
    Inventors: Vincent L. Giranda, Julie M Miyashiro, Thomas D Penning, Keith W. Woods
  • Substituted 2-phenylbenzimidazoles, the production thereof and their use
    Patent number: 7781596
    Abstract: The invention relates to novel 2-phenylbenzimidazoles of general formula (I) or (II), wherein the radicals have the meanings cited in the description, and to their tautomeric forms, possible enantiomeric and diastereomeric forms, to their prodrugs, and to possible physiologically compatible salts. The invention also relates to the production of said compounds and to their use.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: August 24, 2010
    Assignee: Abbott Laboratories
    Inventors: Wilfried Lubisch, Michael Kock, Thomas Höger
  • Thienopyridine and furopyridine kinase inhibitors
    Patent number: 7737160
    Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: June 15, 2010
    Assignee: Abbott Laboratories Inc.
    Inventors: Patrick Betschmann, Andrew F. Burchat, David J. Calderwood, Michael L. Curtin, Steven K. Davidsen, Heather M. Davis, Robin R. Frey, Howard R. Heyman, Gavin C. Hirst, Peter Hrnciar, Michael R. Michaelides, Melanie A. Muckey, Kelly D. Mullen, Paul Rafferty, Carol K. Wada
  • 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
    Patent number: 7728026
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: June 1, 2010
    Assignee: Abbott Laboratories, Inc.
    Inventors: Gui-Dong Zhu, Virajkumar B. Gandhi, Jianchun Gong, Thomas D. Penning, Vincent L. Giranda, Sheela Thomas
  • Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
    Patent number: 7595406
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: September 29, 2009
    Assignee: Abbott Laboratories Inc.
    Inventors: Thomas D. Penning, Sheela A. Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent L. Giranda, Viraj B. Gandhi