Patents Represented by Attorney Susan M. Pellegrino

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  • Factor VII or VIIa-like molecules
    Patent number: 7517974
    Abstract: Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: April 14, 2009
    Assignee: Bayer Healthcare LLC
    Inventors: Anders Hjelholt Pedersen, Kim Vilbour Andersen, Claus Bornaes
  • Factor VII or VIIA-like molecules
    Patent number: 7511024
    Abstract: Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: March 31, 2009
    Assignee: Bayer HealthCare LLC
    Inventors: Anders Hjelholt Pedersen, Kim Vilbour Andersen, Claus Bornaes
  • Human TIMP-1 antibodies
    Patent number: 7432364
    Abstract: Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: October 7, 2008
    Assignee: Bayer HealthCare LLC
    Inventors: Clark Pan, Andreas M. Knorr, Michael Schauer, Claudia Hirth-Dietrich, Sabine Kraft, Barbara Krebs
  • Aza-bicyclic N-biarylamides with affinity for the ?7 nicotinic acetylcholine receptor
    Patent number: 7138410
    Abstract: The invention relates to novel 1-aza-bicyclic N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: November 21, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Joachim Luithle, Frank-Gerhard Böss, Christina Erb, Katrin Schnizler, Timo Flessner, Marja van Kampen, Christoph Methfessel, Frank-Thorsten Hafner
  • 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Patent number: 7122540
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: October 17, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Maria Niewöhner, legal representative, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Semo, Marc Nowakowski, Ulrich Niewöhner, deceased
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 7112597
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: September 26, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • Solid phase dispersion of quinolone or naphthyridonecarboxylic acids
    Patent number: 7112336
    Abstract: The present invention relates to a solid dispersion of quinolone- or naphthyridonecarboxylic acids in an insoluble matrix representative of a shellac, and methods preparing and using the same in masking the taste and improving the uptake by animals.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: September 26, 2006
    Assignee: Bayer HealthCare LLC
    Inventor: Francisco Cabrera
  • Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
    Patent number: 7109218
    Abstract: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
    Type: Grant
    Filed: November 28, 2002
    Date of Patent: September 19, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Ulrich Rosentreter, Thomas Krämer, Mitsuyuki Shimada, Walter Hübsch, Nicole Diedrichs, Thomas Krahn, Kerstin Henninger, Johannes-Peter Stasch, Ralf Wischnat
  • 1,8 Naphthyridine derivatives and their use to treat diabetes and related disorders
    Patent number: 7109196
    Abstract: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: September 19, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Yamin Wang, William H. Bullock, David E. Gunn, Qingjie Liu, Sidney X. Liang, Donglei Liu, Steven R. Magnuson, Tindy Li, Eric S. Mull, Jill E. Wood, Ning Qi
  • Imidazotriazinones and the use thereof
    Patent number: 7098207
    Abstract: Novel imidazotriazinones of general formula a method for the production and the pharmaceutical use thereof are disclosed.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: August 29, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Maria Niewohner, legal representative, Mazen Es-Sayed, Thomas Lampe, Helmut Haning, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Ulrich Niewohner, deceased
  • Imidazo[1,3,5]triazinones and their use
    Patent number: 7091203
    Abstract: The invention relates to imidazo[1,3,5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: August 15, 2006
    Assignee: Bayer Healthcare AG
    Inventors: Ulrich Niewöhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • 2,5-disubstituted pyrimidine derivatives
    Patent number: 7091198
    Abstract: The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of central nervous system diseases.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: August 15, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Achim Feurer, Joachim Luithle, Stephan-Nicholas Wirtz, Gerhard König, Johannes-Peter Stasch, Elke Stahl, Rudy Schreiber, Frank Wunder
  • Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
    Patent number: 7091228
    Abstract: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
    Type: Grant
    Filed: May 6, 2004
    Date of Patent: August 15, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Roger Smith, Ann-Marie Campbell, Philip Coish, Miao Dai, Susan Jenkins, Derek Lowe, Stephen O'Connor, Ning Su, Gan Wang, Mingbao Zhang, Lei Zhu
  • Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity
    Patent number: 7071207
    Abstract: This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: July 4, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Roger A. Smith, Stephen J. O'Connor, Wai C. Wong, Soongyu Choi, Harold C. Kluender, Jianmei Fan, Zhonghua Zhang, Rico C. Lavoie, Brent L. Podlogar
  • Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists
    Patent number: 7041646
    Abstract: The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: May 9, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Clark Pan, James Whelan, Kevin B. Clairmont
  • Substituted imidazotriazinones
    Patent number: 6998402
    Abstract: The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memory retentiveness.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: February 14, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Maria Theresia Niewöhner, legal representative, Dagmar Schauss, Gerhard König, Martin Hendrix, Frank-Gerhard Böss, Franz-Josef van der Staay, Rudy Schreiber, Karl-Heinz Schlemmer, Toshiya Moriwaki, Ulrich Niewöhner, deceased
  • Process for the preparation of sulphonamide-substituted imidazotriazinones
    Patent number: 6998483
    Abstract: The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: February 14, 2006
    Assignee: Bayer HealthCare Aktiengesellschaft
    Inventors: Marc Nowakowski, Reinhold Gehring, Werner Heilmann, Karl-Heinz Wahl
  • Method for assaying enzyme activity
    Patent number: 6994956
    Abstract: The present invention relates to methods for assessing enzyme activity utilizing a phase partition system. In addition, the present invention also relates to methods for screening and identifying compounds that may be used, for example, for the treatment of diabetes, diabetes-related disorders, obesity, cardiovascular disease, cancer, and other diseases or disorders, using this phase partition system.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: February 7, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: James A. Landro, David G. Osterman, Walter Pickett
  • Semi-hydrochloride of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid
    Patent number: 6995170
    Abstract: The present invention relates to a semi-hydrochloride of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, to processes for its preparation and to antibacterial compositions comprising it. The semihydrochloride of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: February 7, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Himmler, Hubert Rast
  • Immunogenic peptides of foot-and-mouth disease viruses
    Patent number: 6984387
    Abstract: The present invention relates to FMDC vaccine based on peptides having a sequence of at least 8 amino acids, which corresponds to a partial sequence of the non-structural protein region of FMDV, which was selected by immunoreactivity with FMDV-specific antibodies or by immunoreactivity with FMDV-specific T lymphocytes, and to their production and their use.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: January 10, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Roberto Correa, Hans-Robert Hehnen, Eberhard Pfaff, Armin Saalmüller, Thomas Pauly, Bettina Höhlich, Bernadette Glatthaar-Saalmüller, Karl-Heinz Wiesmüller