Patents Represented by Attorney, Agent or Law Firm Suzanne E. Babajko
  • 10'-Desmethoxystreptonigrin
    Patent number: 5158960
    Abstract: 10'-Desmethoxystreptonigrin, obtainable by cultivation of a strain of Streptomyces albus, A.T.C.C. No. 55161, and salts, esters and amides thereof. The novel compounds have antitumor and antibiotic activity.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: October 27, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward Meyers, Terrence W. Doyle, Veeraswamy Manne, Wen-Chih Liu
  • Enzymatic process for enantiomer-specific perparation of mercapto alkanoic acid compounds
    Patent number: 5106736
    Abstract: An enzymatic process for the enantiomer-specific preparation of mercapto alkanoic acids by stereoselective hydrolysis of mercapto or thioester alkanoic acid esters.
    Type: Grant
    Filed: April 23, 1991
    Date of Patent: April 21, 1992
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Laszlo J. Szarka
  • Dihydropyrimidine lactone derivatives
    Patent number: 5103006
    Abstract: Novel compounds of the formula ##STR1## wherein X is sulfur or oxygen, R.sub.2 is aryl or heterocyclo and R.sub.1 is as defined herein, are disclosed. Compounds of formula I possess calcium channel activating activity.
    Type: Grant
    Filed: August 21, 1990
    Date of Patent: April 7, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: George C. Rovnyak, Spencer D. Kimball
  • Process for preparing [1S-[1.alpha.,2.alpha.(Z),3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-ami no]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
    Patent number: 5081266
    Abstract: A new process for preparing [1S-[1.alpha.,2.alpha.(Z),-3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-amin o]acetyl]amino]methyl]-7-oxabicyclo [2.2.1]-hept-2-yl]-5-heptenoic acid. New intermediates are also described. [1S-(1.alpha.,2.alpha.(9Z),3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-amin o]acetyl]amino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid is useful in the treatment of thrombotic disease.
    Type: Grant
    Filed: September 26, 1990
    Date of Patent: January 14, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: David Kronenthal
  • Pyranyl quinoline calcium channel blockers
    Patent number: 5070088
    Abstract: Novel calcium channel blockers having the formula ##STR1## wherein X is oxygen or sulfur and wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 are as defined herein, are disclosed. These compounds are useful, for example, as anti-ischemic agents.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: December 3, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal