Patents Represented by Attorney, Agent or Law Firm Swiss Law Group
  • Process for the racemization of chiral quinazolinones
    Patent number: 6753428
    Abstract: Racemates are obtained from one of the enantiomers, or an enantiomerically enriched mixture, of an optically active quinazolinone derivative by reaction of the compound with an alkali alkoxide of a primary alcohol and isolation of the racemate.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: June 22, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: Gustave Bergnes, Bing Yao, David Morgans, Jr., Whitney W. Smith
  • Chronic lymphocytic leukemia treatment
    Patent number: 6733748
    Abstract: Chronic lymphocytic leukemia (CLL) in a patient is treated by administering to the patient oxidatively stressed CLL cells. The CLL cells are oxidatively stressed extracorporeally, e.g. by subjection to oxygen/ozone mixtures, and preferably are simultaneously subjected to other stressors such as UV light. Preferably also, the CLL cells are autologous, and are contained in an aliquot of the patient's blood at the time of subjection to stressing.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: May 11, 2004
    Assignee: Vasogen Ireland Limited
    Inventor: David Elliott Spaner
  • Apparatus for screening compound libraries
    Patent number: 6723235
    Abstract: Disclosed are apparatus for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. The apparatus of this invention also permit a compound library to be rapidly screened to determine if any member of the library has an affinity for the target receptor as measured by a pre-selected indicator compound.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: April 20, 2004
    Inventors: Ole Hindsgaul, David C. Schriemer
  • Methods for screening compound libraries
    Patent number: 6720190
    Abstract: Disclosed are methods for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. Methods are also disclosed which permit a compound library to be rapidly screened to determine if any member of the library has an affinity for the target receptor as measured by a pre-selected indicator compound.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: April 13, 2004
    Inventors: Ole Hindsgaul, David C. Schriemer
  • Dissolution and decontamination process
    Patent number: 6716402
    Abstract: The present invention concerns a process for dissolving ruthenium deposits that are present on a surface and a process for decontaminating the internal circuits of nuclear fuel reprocessing plants using the said dissolution process. The process according to the invention comprises bringing the said surface into contact with an aqueous solution of perruthenate, with the said aqueous solution having a pH equal to or greater than 12, so that the ruthenium is oxidised.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: April 6, 2004
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Jean-Michel Fulconis, Jacques Delagrange, Francis Dalard
  • High efficiency ion exchange system for removing arsenic from water
    Patent number: 6706195
    Abstract: The disclosed invention is a fixed bed ion exchange system from removing arsenic from water. It employs a combination of electronically controlled process steps and specific systems configurations to duplicate the effects of moving resin beds from one operating position to another as is required in moving bed ion exchange water purification systems. The invention combines features of single fixed bed ion exchange systems with those of a moving bed system.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: March 16, 2004
    Inventors: Peter L. Jensen, Gerald A. Guter, Dan Ziol
  • Contoured syringe and novel luer hub and methods for embolizing blood vessels
    Patent number: 6699222
    Abstract: Disclosed are novel syringes and catheters for delivering compositions which form solid masses in vivo. These syringes and catheters are particularly useful for delivering embolizing compositions intravascularly.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: March 2, 2004
    Assignee: Micro Therapeutics, Inc.
    Inventors: Michael L. Jones, Richard J. Greff
  • Endothelial lining effects and treatment of vasospastic disorders
    Patent number: 6696092
    Abstract: Vasospastic disorders are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment so as to render the blood aliquot capable of generating in the patient's blood stream after administration a population of stimulated leukocytes having upregulated expression of CD25 cell surface markers, along with an enhancement of endothelial function in the patient.
    Type: Grant
    Filed: March 15, 1999
    Date of Patent: February 24, 2004
    Assignee: Vasogen Ireland Limited
    Inventor: Anthony E. Bolton
  • Phenylalanine derivatives as alpha 4 integrin inhibitors
    Patent number: 6689781
    Abstract: Disclosed are a series of phenylalanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: February 10, 2004
    Assignees: Elan Pharmaceuticals, Inc., American Home Products Corporation
    Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett, Susan Ashwell, Gregory S. Welmaker, Anthony Kreft, Dimitrios Sarantakis, Darren B. Dressen, Francine S. Grant, Christopher Semko, Ying-Zi Xu