Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
February 15, 1980
Date of Patent:
August 25, 1981
Merck & Co., Inc.
Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo