Abstract: A compound of formula I
or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for reducing Insulin resistance in humans in whom Impaired Glucose Tolerance and Non-Insulin Dependent Diabetes Mellitus have not presented.
Type:
Grant
Filed:
October 30, 2000
Date of Patent:
September 9, 2003
Assignee:
Knoll Aktiengesellschaft
Inventors:
Clifford James Bailey, Robert Brian Jones, Helen Christine Jackson
Abstract: The use of (+)-sibutramine in the treatment of depression, obesity, Parkinson's disease, cerebral function disorders and diabetes is described.