Abstract: An injection control device having a metered/controlled injection rate proportional to the rate of withdrawal/injection, suitable for cosmetic as well as other applications is described. For example, after the cannula is advanced into an object, the cannula is withdrawn to create a tract or tunnel within the targeted area. As the cannula is withdrawn, filler material in the injection control device is uniformly deposited into the tract or tunnel via the automatic metering system. The automatic metering system incorporates a syringe activating mechanism coupled to a system which is capable of proportioning the deposition rate to the retraction/injection rate of the cannula. Accordingly, more consistent and uniform distribution of the material injected can be achieved with less cannula passes as well as requiring less dependence on the skills of the practitioner of this device.

Abstract: Provided are synthetic polysaccharide antigens (SPAs) with anti-inflammatory or inflammatory immunomodulatory properties, depending on their structure. Also provided are compositions comprising these SPAs, and methods of using these SPAs and compositions to either prevent or treat inflammatory pathologies, or diseases or conditions susceptible to treatment with inflammatory immunomodulators, by using appropriate SPAs.

Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.

Abstract: An abdominal training device includes a stationary base with a user support surface and a hub connected to a track with a friction mitigation unit and a track anchor. A console is slidably mounted on the track and includes a hand support member and a console anchor. A bearing is fixedly mounted to the proximal end of the track and supports an elastic resistance element with one end attached to the track anchor and the other end attached to the console anchor. A beam rigidly connects the track to the hub of the stationary base so that the track is at least partially rotatable about the hub of the stationary base. The device may also include an electronic training program that directs a user to rotate the track to specified positions. The device may be part of an abdominal training kit.

Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

Abstract: Improvements in a semiconductor wafer container including improvements in side protection to the wafers, improved cover design to minimize rotation, a simplified top cover orientation mechanism and an improved bottom holding mechanism for automation. The side protection to the wafers is with multiple staggered inner and outer walls. The improved cover design improves alignment of the top and bottom housings and minimizes rotation of the housings in transit or motion. The housings have a recessed tab ramp feature with bi-directional locking that also increases the rigidity of the containment device when the two housings are assembled. The improved bottom holding mechanism for automation is an integrated feature that is molded into the bottom housing and not assembled in a secondary operation. The molded integration reduces tolerance errors that are present in assembling multiple pieces and joining multiple pieces.

Abstract: An apparatus is provided. The apparatus includes a tube having a first end and a second end. The second end prevents access to an inner wall of the tube. Further, the apparatus includes a valve operably connected to the first end of the tube and configured to provide access to the inner wall of the tube to a guiding member inserted through the valve. The guiding member positions the tube in an umbilical vessel of an umbilical cord prior to occlusion of the umbilical vessel so that the tube remains within the umbilical vessel after occlusion of the umbilical vessel.

Abstract: An exercise device for the mid to lower body muscles comprising an inclined base, a base frame to support the base a first support bar and a second support bar, the first and the second support bar each having a mounting end and a support end, wherein the first support bar mounting end is pivotably attached to a first pivot point and the second support bar mounting end is pivotably attached to a second pivot point and the first and the second support bar support end are movably mounted on the perimeter of the base such that the first and the second support ends are movable through an arcuate path along the perimeter of the base a first knee pad pivotably attached to the first support bar at the first support bar support end; a second knee pad pivotably attached to the second support bar at the second support bar support end; and a handle attached to the front portion of the base frame.

Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. A signaling chromophore absorbs energy from the excited multichromophore and emits light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits having reagents for performing such methods are also provided.

Abstract: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.

Abstract: We have identified ZNF206, a novel repressor of human embryonic stem cell (hESC) differentiation. Repressing extra-embryonic endoderm development preserves the pluripotent state of human embryonic stem cells, and, conversely downregulating expression of ZNF206 in hESCs causes them to upregulate the expression of genes associated with the extra-embryonic endodermal lineage, down-regulate genes associated with the pluripotent state, and may lead to the further emergence of genes associated with even more differentiated lineages and phenotypes.

Abstract: A fuel cell device comprising: (a) a catalytic oxidizer; (b) means for delivering gaseous fuel and oxidizer to the catalytic oxidizer; and (c) a fuel cell assembly located in the vicinity of the catalytic oxidizer such that the fuel cell assembly is able to be heated by heat generated from the reaction of fuel and oxidizer at the catalytic oxidizer; wherein the fuel cell assembly causes the generation of hot gases and an electrical output when it is heated and supplied with fuel and oxidizer, and wherein the device is provided with (d) a heat outlet which allows hot gases generated by the device to be directed out of the device and to applications requiring heat. Also provided is the use of such a device to generate heat and/or electrical power, and an appliance comprising such a device.

Abstract: Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keap1/Nrf2 complex.

Abstract: In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPS) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein. Also provided are compositions and methods for targeting the destruction of selected polypeptides in eukaryotic cells based on the ubiquitin-independent mechanism by which ornithine decarboxylase is degraded by the 26S proteasome.

Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

Abstract: We used Accutase™, a commercially available cell detachment solution, for single cell propagation of pluripotent hESCs. Unlike trypsin dissociation, Accutase treatment does not significantly affect the plating efficiency of hESC dissociation into single cells. Cultures dissociated with Accutase to single cells at each passage maintain a higher proportion of pluripotent cells as compared to collagenase-passaged hESCs. Accutase-treated hESCs can be grown to a high density as monolayers, and yet retain their pluripotency.

Abstract: An exercise device is disclosed having at least a base, first and second knee supports which are bilaterally coupled to first and second pivots located off from the center of the base. Independently rotatable knee pads are coupled to the perimeter-side end of the first and second knee supports arranged around a perimeter of the base. An upper extremity support is coupled to the base, and a first base supporting member is positioned at a rear of the base and a second base supporting member is positioned at a front of the base, wherein at least one of an inclination and elevation of the base is determined by adjustment of the base supporting members, wherein the first and second knee supports move around different arcs to generate an elliptical motion for an individual.