Patents Represented by Attorney Ted Apple

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  • Treatment of benign prostatic hyperplasia
    Patent number: 6989400
    Abstract: A method for treatment or prophylaxis of benign prostatic hyperplasia by administration of lonidamine or a lonidamine analog is provided. Also provided are unit dosage forms of lonidamine or an analog, useful for such treatment and prophylaxis.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: January 24, 2006
    Assignee: Threshold Pharmaceuticals, Inc.
    Inventor: George Tidmarsh
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 6921650
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: July 26, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 6858411
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 22, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Polyketide synthase genes from Streptomyces venezuelae
    Patent number: 6503741
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: January 7, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Use of interleukin-10 to produce a population of suppressor cells
    Patent number: 6277635
    Abstract: Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft-versus-host disease or tissue rejection, is described. Interleukin-10 for reducing responses in mixed lymphocyte response (MLR) is also described. Exogenous or induced endogenous IL-10 may be used for the inhibition or suppression of the reactions to alloantigens.
    Type: Grant
    Filed: May 6, 1996
    Date of Patent: August 21, 2001
    Assignee: Schering Corporation
    Inventors: Maria-Grazia Roncarolo, Rene de Waal Malefyt, Rosa Bacchetta, Herve M. Groux, Jan E. de Vries