Patents Represented by Attorney, Agent or Law Firm Teresa J. Welch
  • Direct detection and mutation analysis of low copy number nucleic acids
    Patent number: 6261781
    Abstract: A direct detection and quantitation of RNA or DNA contained in a sample is obtained by capillary electrophoresis of the RNA or DNA hybridized to a DNA or RNA probe of complementary sequence stabilized by the combination of a fluorophore terminally conjugated to the probe and a dye intercalating the RNA-DNA or DNA-DNA hybrid so formed. The RNA or DNA is quantified by measuring the total fluorescence emitted by the electrophoresed hybrid upon excitation by a laser generated light beam.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: July 17, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Jill M. Kolesar
  • Methods for preparation and use of 1&agr;,24(S)-dihydroxy vitamin D2
    Patent number: 6251883
    Abstract: 1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: June 26, 2001
    Assignee: Bone Care International, Inc.
    Inventors: Ronald L. Horst, Charles W. Bishop, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • 24-hydroxyvitamin D, analogs and uses thereof
    Patent number: 6242434
    Abstract: The invention provides 24-hydroxyvitamin D compounds and methods for their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the immune and inflammatory responses as well as the treatment of bone depletive disorders.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: June 5, 2001
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Joyce C. Knutson, Stephen Strugnell
  • Methods for preparation and use of 1&agr;,24 (S)-dihydroxy vitamin D2
    Patent number: 6211168
    Abstract: 1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 3, 2001
    Assignees: Bone Care International, Inc, The United States of America as represented by the Secretary of Agriculture
    Inventors: Charles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
  • Prostate cell surface antigen-specific antibodies
    Patent number: 6207805
    Abstract: Disclosed is an antibody that binds to a protein found on normal and cancerous prostate cells, but not found on nonprostate cells and a hybridoma that produces the antibody to the prostate-specific protein. Also disclosed are antibodies conjugated to labels or cytotoxic moieties.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: March 27, 2001
    Assignee: University of Iowa Research Foundation
    Inventors: George J. Weiner, Oskar W. Rokhlin, Michael B. Cohen