Abstract: A patient ventilator system for automatically weaning a patient from a ventilator.

Abstract: Systems and methods provide a user the ability to select three-dimensional virtual objects in a three-dimensional modeling environment using two-dimensional representations of the objects. In broad overview, the invention involves a multidimensional degree of freedom haptic interface that controls a three-dimensional cursor. A user employs the cursor to select an arbitrary point on a three-dimensional virtual object of interest. Through the application of a mathematical transformation, the system displays the cursor at the location of the selected point on the object. The user can manipulate the object by operating the haptic interface. The systems and methods provide the user with the possibility of editing the selected virtual object. In one embodiment, editing includes sculpting the object. When the user releases the object after manipulation is completed, the cursor is relocated to the position the cursor would have had had the manipulations been applied to the cursor directly.

Abstract: Disclosed herein are expandable surgical implants that may be expanded one or more times by directly or indirectly uncinching one or more expansion loops. Use of the expandable surgical implant permits a physician to expand, with minimal invasion, a surgical implant that was over-tensioned by a surgeon during implantation or became over-tensioned due to changes in the patient's anatomy.

Abstract: A configurable baffle to configure fluid flow through a nozzle. To improve the quality and accuracy of processing apparatus used in the cutting, welding, and heat treating of materials, a self-aligning nozzle includes a configurable baffle. This configurable baffle can be a metallic grid (e.g., a screen) or other type of membrane (e.g., porous, permeable, etc.). During its initial use in the processing apparatus, this configurable baffle is tailored with an energy beam, such as a laser beam or plasma jet, to create an optimal fluid flow velocity profile. When the configurable baffle deteriorates from use, it is easily replaced by another baffle or by using an in situ replacement mechanism. To ensure proper alignment between the nozzle and the energy beam, mating contoured surfaces are used among adjacent components. Threaded surfaces can also be employed to assist in achieving the proper coaxial alignment.

Abstract: The present invention is directed to peptides that interacts with thrombospondin 2 and inhibit matrix metalloproteinase 9 (MMP-9) activity. Consequently, the invention provides peptides that inhibit MMP-9 activity and are useful as inhibitors of angiogenesis and metastasis, among other diseases regulated by MMP-9. The peptides of the invention and their methods of use are therapeutic against diseases, such as cancer and arthritis, which are characterized by neovascularization.

Abstract: Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.

Abstract: A delivery catheter for delivering material(s) into the body of a mammal can include a first elongated member and a second elongated member. At least a portion of the second elongated member can be slidably disposed within a lumen of the first elongated member. The delivery catheter can mix two materials and then introduce the mixed materials into the body of a mammal.

Abstract: An apparatus for dissociating gases includes a plasma chamber that may be formed from a metallic material and a transformer having a magnetic core surrounding a portion of the plasma chamber and having a primary winding. The apparatus also includes one or more switching semiconductor devices that are directly coupled to a voltage supply and that have an output coupled to the primary winding of the transformer. The one or more switching semiconductor devices drive current in the primary winding that induces a potential inside the chamber that forms a plasma which completes a secondary circuit of the transformer.

Abstract: Novel addressing schemes for controlling electronically addressable displays include a scheme for rear-addressing displays, which allows for in-plane switching of the display material. Other schemes include a rear-addressing scheme which uses a retroreflecting surface to enable greater viewing angle and contrast. Another scheme includes an electrode structure that facilitates manufacture and control of a color display. Another electrode structure facilitates addressing a display using an electrostatic stylus. Methods of using the disclosed electrode structures are also disclosed. Another scheme includes devices combining display materials with silicon transistor addressing structures.

Abstract: Electrically (and, possibly, mechanically) active patterns are applied using a colloidal suspension of nanoparticles that exhibit a desired electrical characteristic. The nanoparticles are surrounded by an insulative shells that may be removed by therefrom by application of energy (e.g., in the form of electromagnetic radiation or heat). The nanoparticle suspension is applied to a surface, forming a layer that is substantially insulative owing to the nanoparticle shells. The applied suspension is exposed to energy to remove the capping groups and fuse the particles into cohesion. If the nanoparticle suspension was deposited as a uniform film, the energy is applied in a desired pattern so that unexposed areas remain insulative while exposed areas exhibit the electrical behavior associated with the nanoparticles. If the nanoparticle suspension was deposited in a desired pattern, it may be uniformly exposed to energy.

Abstract: A method for treating wrinkles in skin involves the use of a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.

Abstract: Waste-treatment processes are enhanced through generation and introduction of specific biological populations customized to perform or favor specific tasks either during the main process, or for solids minimization purposes in a post-treatment process. These bacteria may be grown from specialized mixes of activated sludge and waste influent by exposing these materials to controlled environments (e.g., in an off-line treatment area). They may then be added back to the main process to perform certain tasks such as converting particulate cBOD into soluble cBOD for utilization, to reduce high solids yield organisms by supplementing the population with low yield organisms, to improve nitrification/denitrification efficiency, or to disfavor filamentous biology such as Norcardia sp.

Abstract: A bone anchor placement device includes a handle and a shaft extending in a distal direction from the handle. A head is disposed at a distal end of the shaft and a retractable anchor driver is disposed within the head. The recessed anchor mount is operable to advance from the head during placement of an anchor in to a supporting structure. The recessed anchor mount is operable to retract into the head during insertion of the placement device within a human body. The recessed anchor mount may include a push wire for advancing and retracting the retractable anchor mount.

Abstract: A structural chassis includes a structural chassis and a foam chassis or sock liner sandwiched together to form an assembly that can be inserted into and substantially occupy a footbed of a shoe upper. Discrete sole elements are attached to a bottom side of the upper so as to expose certain portions of the bottom side therebetween. This absence of outsole material in those areas makes the upper collapsible about those areas since the outsole provides no support in those areas. Instead, the structure is provided by the chassis of the chassis, which is customized to the user's foot by placing one or more notches in strategic locations along the chassis where the foot naturally flexes. One such notch is located on the chassis in a position that allows the chassis to flex about a forward push-off axis of the foot that runs through the first and second MTP joints.

Abstract: A wireless, in-road traffic sensor system using sensors that are small, low-cost, and rugged. The sensors may be capable of measuring the speed of passing vehicles, identifying the type of passing vehicle and measuring information about roadway conditions, e.g., wet or icy. The sensor includes a wireless transmitter and may be configured for installation beneath a roadway surface. The sensors may be configured as a traffic sensor system including distributed sensors across a roadway system, concentrators for receiving the sensor broadcasts and a central computer for accumulating and organizing the sensed information. The sensed information may also be made available responsive to user requests via the Web through such reports as traffic delays, alternate route planning and travel time estimates. Alternatively, the sensed information may also be used to control traffic through a traffic control means, such as a traffic signal.

Abstract: A system for imparting and detecting mechanical energy includes a projectile and a hollow tube allowing the projectile to move therein. A portion of the projectile is allowed to emerge from one end of the tube and thereby transfer mechanical energy to a receiving entity, e.g., a wound roll of material. An actuator drives the projectile through the tube, and a first sensor detects when the protruding portion of the projectile extends from the tube to make contact with, for example, the core of the wound roll to start a timing sequence. A second sensor detects the arrival of the mechanical energy at, for example, the roll surface so that a comparison can be made between the start and end times.

Abstract: Methods and apparatus to reduce or eliminate misalignment, wrinkles, and creases in coated web product. A relationship between web outgassing pressure and surface roughness of the web and web transporting rollers is developed. This relationship allows for the control over the web outgassing pressure. The ability to adjust the web tension pressure, as well as the selection of web transporting rollers with prescribed surface characteristics, allows an operator to control the degree to which the web floats over or tracks the web transporting roller. A controller, in response to pressure and tension sensors, can also provide dynamic, closed-loop control of the entire system.

Abstract: A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region of the tubular segment and to transport urine from there across the ureter/bladder junction and into the bladder. The tails include an elongated external urine-transport surface sized and configured to transport urine along the ureter. The urine transporting surface(s) are sized and configured to extend along at least part of the ureter, across the ureter/bladder junction, and from there into the bladder.

Abstract: An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.