Patents Represented by Attorney, Agent or Law Firm The firm of Gordon W. Hueschen
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Patent number: 5569669Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.2', R.sub.2", R.sub.2'", R.sub.3 and n are as defined in the description, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable acid or base,and medicinal product containing the same useful for treating a mammal afflicted with a disorder associated to 5-HT.sub.1A or 5-HT.sub.2C receptors.Type: GrantFiled: March 10, 1995Date of Patent: October 29, 1996Assignee: Adir et CompagnieInventors: G erald Guillaumet, Marie-Claude Viaud, Pierre Renard, G erard Adam, Daniel-Henri Caignard, B eatrice Guardiola-Lemaitre, Marie-Claire Rettori
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Patent number: 5569647Abstract: The invention relates to a compound selected from those of formula (I) (SEQ ID NO:1): ##STR1## in which R.sub.1, R.sub.2, X.sub.1 and X.sub.2 are as defined in the description, useful as inhibitor of the proliferation component of vascular smooth muscle cells.Type: GrantFiled: June 6, 1995Date of Patent: October 29, 1996Assignee: Adir et CompagnieInventors: Jean-Luc Fauchere, Christophe Thurieau, Jean-Paul Vilaine, Philip Janiak
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Patent number: 5567804Abstract: Compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl or (C.sub.3 -C.sub.7) cycloalkylR.sub.2 represents alkyl, or (C.sub.3 -C.sub.7) cycloalkyl,R.sub.3 represents hydrogen or alkyl,R.sub.4 represents halogen or alkyl or alkoxy,R.sub.5 represents alkyl,X and Y, which are different, represent CO or SO.sub.2,n represents 1, 2 or 3,p represents 0 or 1,Z represents sulfur or oxygen,A represents any one of the following groups: ##STR2## in which: A.sub.1 represents, with the nitrogen and carbon atoms to which it is attached, a mono- or bicyclic heterocycle,.cndot. or, ##STR3## in which: R.sub.6 represents hydrogen, alkyl or cycloalkyl or 2-indanyl,R.sub.7 represents hydrogen or alkyl,which compounds of formula (I) comprise thereof corresponding hydrates of the ketone function COCF.sub.3,the enantiomers, diastereoisomers and epimers thereof and the addition salts thereof with a pharmaceutically acceptable base and medical products containing the same are useful as HLE inhibitor.Type: GrantFiled: May 5, 1995Date of Patent: October 22, 1996Assignee: Adir et CompagnieInventors: Guillaume de Nanteuil, Bernard Portevin, Emmanuel Canet
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Patent number: 5567707Abstract: Compounds of formula (I): ##STR1## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6, X and Y are defined in the description.Those compounds are used therapeutically in the treatment of cancerous tumours.Type: GrantFiled: February 16, 1995Date of Patent: October 22, 1996Assignee: Adir et CompagnieInventors: Michel Koch, Fran.cedilla.ois Tillequin, Alexios-Leandros Skaltsounis, Yves Rolland, Alain Pierre, Ghanem Atassi
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Patent number: 5567797Abstract: The object of the present invention is a polyamide composition containing, in reference to the polyamide composition 0.1 to 1 wt. % terephthaldialdehyde and/or its acetals of C.sub.1 --C.sub.4 alcohols and optionally 3 to 30 wt. % melamine and/or melamine cyanurate as well as a process for the production of the polyamide, a process to increase the shock resistance, notched impact resistance and viscosity of flameproof, halogen-free polyamides, and a process to increase the mass of such polyamides.Type: GrantFiled: February 27, 1995Date of Patent: October 22, 1996Assignee: A. Schulman, Inc.Inventors: Hubert Christ, Wolfgang Schneider
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Patent number: 5565426Abstract: The invention relates to peptide compounds of formula (I):R.sub.1 --A--Gly--Asp--Trp--R.sub.2 (I)in which R.sub.1, R.sub.2 and A are as defined in the description, and anti-aggregation medicaments containing the same.Type: GrantFiled: August 11, 1994Date of Patent: October 15, 1996Assignee: Adir et CompagnieInventors: Jean-Luc Fauchere, Angela D. Morris, Christophe Thurieau, Tony Verbeuren, Serge Simonet
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Patent number: 5565457Abstract: The compounds are N-(2,3,4-trimethoxybenzyl)piperazines N'-substituted by a radical containing a sulfonamide group, and pharmaceutically tolerable salts thereof, useful for treating myocardial ischaemic pathologies, cerebral vascular accident and manifestations of deficiency associated with chronic cerebral circulatory disorders.A compound disclosed is : N-benzyl-N-{3,3-dimethyl-4-[4-(2,3,4-trimethoxybenzyl) piperazin-1-yl]butyl}-(isoquinolin-5-yl)sulfonamide and its fumarate.Type: GrantFiled: February 23, 1995Date of Patent: October 15, 1996Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Jean-Paul Vilaine, Nicole Villeneuve, Jean-Pierre Iliou, Jean-Pierre Bidouard
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Patent number: 5565429Abstract: Compounds of formula (I): ##STR1## wherein: R.sub.1 represents an unsubstituted or substituted alkyl,R.sub.2 represents an unsubstituted or substituted alkyl,A represents, with the nitrogen and carbon atoms to which it is attached, a nitrogenous mono- or polycyclic structure, andB represent any one of the radicals a through j as defined in the description, and medicaments containing the same, are useful as human leucocyte elastase inhibitors.Type: GrantFiled: May 11, 1995Date of Patent: October 15, 1996Assignee: Adir et CompagnieInventors: Michel Vincent, Guillaume de Nanteuil, Georges Remond, Bernard Portevin, Yolande Herve, Emmanuel Canet, Michel Lonchampt
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Patent number: 5561113Abstract: A compound of formula (I): ##STR1## in which: R represents naphthyl, 5,6,7,8-tetrahydronaphthyl, 1,2,3,4-tetrahydronaphthyl, thienyl, optionally substituted phenyl or (C.sub.3 -C.sub.7)cycloalkyl,n represents an integer such that 1.ltoreq.n.ltoreq.8, their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as antagonists of substance P.Type: GrantFiled: April 26, 1995Date of Patent: October 1, 1996Assignee: Adir ET CompagnieInventors: Jean-Luc Fauchere, Nathalie Kucharczyk-Gentric, Joseph Paladino, Jacqueline Bonnet, Emmanuel Canet, Graham Birrell
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Patent number: 5557256Abstract: A valve cap is screwed onto a pneumatic tire and generates an indication whether a prefilled tire pressure is still existent or not. For this purpose a valve cap (1) comprises a deflectable diaphragm (30) in an inner housing separating a pressure chamber from a reference pressure chamber. The reference pressure chamber registers the prefilled tire pressure. The diaphragm (30) is deflected toward the closed housing end when the actual existent tire pressure drops in comparison with the registered tire pressure. Onto the diaphragm (30) a permanent magnet (40) is placed, which can be in a first position (normal position of the diaphragm) or in a second position adjacent to the housing end. The check of the magnet position and the generation of an indication signal indicative of the actual tire pressure status will be executed by a hand device, which must be brought into a defined position with respect to the valve cap.Type: GrantFiled: April 29, 1994Date of Patent: September 17, 1996Assignee: Auto-Zubehor-Innovationen Gasellschaft mbHInventor: Rainer Achterholt
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Patent number: 5554630Abstract: The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.Type: GrantFiled: March 24, 1995Date of Patent: September 10, 1996Assignees: NeuroSearch A/S, Meiji Seika Kaisha, Ltd.Inventors: Lene Teuber, Oskar Axelsson, Frank W atjen
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Patent number: 5554626Abstract: The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sup.3, and R.sub.4 each have the meanings set forth in the specification.The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.Type: GrantFiled: July 16, 1993Date of Patent: September 10, 1996Assignee: NeuroSearch A/SInventors: Peter Moldt, J.o slashed.rgen Scheel-Kr uger, Leif H. Jensen
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Patent number: 5554632Abstract: The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.Type: GrantFiled: December 9, 1994Date of Patent: September 10, 1996Assignees: NeuroSearch A/S, Meiji Seika Kaisha, Ltd.Inventors: Lene Teuber, Oskar Axelsson, Frank Watjen
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Patent number: 5554642Abstract: A compound which is selected from those of formula (I): ##STR1## in which A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined in the description,its optical isomers and its addition salts thereof with a pharmaceuticaliy-accepable acid or base,and medicinal products containing the same which are useful for treating a disorder of the melatoninergic system.Type: GrantFiled: May 22, 1995Date of Patent: September 10, 1996Assignee: Adir et CompagnieInventors: Michel Langlois, Pierre Renard, G erard Adam
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Patent number: 5554713Abstract: Polyurethane-urea polymers comprising inter-reacted isocyanate A), diol or polyol components B) and C), chain-extending glycol component D), polyester diol or polyol component E), and polyamine component F) using a polyurethane catalyst G) and an optional drying agent, each component having the further characteristics set forth in the Specification and each component being present in the relative proportions by weight as set forth in the Specification, have improved characteristics including a reduced flow time and diminished end-waste characteristics which obviate the necessity of taping a channel in a metal extrusion into which such polymers are poured to provide a thermal barrier in the bridged or debridged channel and are accordingly advantageously employed as thermal barriers in such structures.Type: GrantFiled: January 6, 1995Date of Patent: September 10, 1996Assignee: Azon USA Inc.Inventor: Gerard S. Freeland
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Patent number: 5552418Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification,and a medicinal product containing said compound for treating a disorder of the melatoninergic system.Type: GrantFiled: May 23, 1995Date of Patent: September 3, 1996Assignee: Adir et CompagnieInventors: Patrick Depreux, Hamid Ait Mansour, Daniel Lesieur, Fran.cedilla.ois Lefoulon, Pierre Renard, G erard Adam, Philippe Delagrange
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Patent number: 5550143Abstract: A compound of formula (I): ##STR1## in which X, n, B and Y are as defined in the description. useful as cytokine inhibitors.Type: GrantFiled: April 12, 1994Date of Patent: August 27, 1996Assignee: Adir et CompagnieInventors: Jean-Daniel Brion, Anne-Marie Chollet, Luc Demuynck, Lucy De Montarby, Yves Rolland, Jacqueline Bonnet, Pietro Ghezzi, Armel Fradin
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Patent number: 5536709Abstract: Compound of formula (I): ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino; or a group ##STR3## in which R.sub.6 and R.sub.Type: GrantFiled: August 30, 1994Date of Patent: July 16, 1996Assignee: Adir et CompagnieInventors: Alex Cordi, Patrice Desos, Jean Lepagnol
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Patent number: 5534517Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## wherein Ar, n, B and A are as defined in the description, to their optical isomers, and to their addition salts there of with a pharmaceutically-acceptable acid or base. The compounds are useful for treating or preventing anxiety and depression.Type: GrantFiled: August 26, 1994Date of Patent: July 9, 1996Assignee: Adir Et CompagnieInventors: Ousmane Diouf, Daniel Lesieur, Patrick Depreux, Beatrice Guardiola-Lemaitre, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
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Patent number: 5527552Abstract: The water-soluble and fat-insoluble polyphenolic antioxidants (catechins) present in green tea are made into solution in an edible nonionic lipid-soluble solvent for the tea catechins selected from the group consisting of a fatty alcohol containing 8 to 18 carbon atoms, inclusive, preferably 12 to 14 carbon atoms, inclusive, and a non-ionic surface active agent selected from the group consisting of glyceryl mono-oleate, liquid mono- and di-glycerides, acylated mono- and di-glycerides, benzyl alcohol, triacetin, caproic-caprylic acid polyglycerides, polysorbate, especially glyceryl mono-oleate, and mixtures thereof, which solutions are effective antioxidants in fats, oil, foods, and ingredients of foods without imparting undesirable flavors, aromas, and precipitates. Since it is known that tea polyphenols have positive effects on human health, the resulting stabilized lipids can be considered to have nutritional qualities superior to the same lipid stabilized with common synthetic antioxidants.Type: GrantFiled: December 9, 1994Date of Patent: June 18, 1996Assignee: Kalamazoo Holdings, Inc.Inventor: Paul H. Todd, Jr.