Patent number: 6451789
Abstract: Compound of formula (I):
wherein:
n represents 0 or 1,
R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl,
R2 represents alkyl,
X represents oxygen, chlorine, OR3, SR4 or NOR5,
R3 represents hydrogen , alkyl, acyl, alkoxycarbonyl or arylalkoxycarbonyl,
R4 represents hydrogen, alkyl or aryl,
R5 represents hydrogen or optionally substituted alkyl,
represents a single or double bond,
Ar represents aryl or heteroaryl, its isomers and addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful as facilitators of memory and cognition and antalgic agents.
Type:
Grant
Filed:
September 26, 2001
Date of Patent:
September 17, 2002
Assignee:
Les Labortoires Servier
Inventors:
Sylvain Rault, Olivier Renault, Jean Guillon, Patrick Dallemagne, Pierre Renard, Bruno Pfeiffer, Pierre Lestage, Marie-Cécile Lebrun
Patent number: 6420413
Abstract: A compound selected from those of formula (I):
wherein:
denotes single bond or double bond,
n is integer from 1 to 6 inclusive,
R1, and R2 represent a group selected from hydrogen, linear or branched (C1-C6)-alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl,
X represents a group selected from —CH═CH—, oxygen, S(O)m wherein m is integer from 0 to 2 inclusive, and NR3 wherein R3 represents a group as defined in the description,
Y represents CH or CH2 depending on whether
denotes single bond or double bond, or may have the additional meaning of oxygen when X represents oxygen,
T represents monocyclic or polycyclic (C3-C10)cycloalkyl optionally containing within the ring system oxygen, selenium, S(O)p, NR3, or SiR4R5 wherein p, R3, R4, and R5 are as defined in the description,
its isomers and addition salts thereof with a pharmaceutically-accep
Type:
Grant
Filed:
April 12, 2001
Date of Patent:
July 16, 2002
Assignee:
Les Laboratories Servier
Inventors:
Jean-Louis Peglion, Aimée Dessinges, Bertrand Goument, Mark Millan, Françoise Lejeune, Mauricette Brocco
Patent number: 6350757
Abstract: A compound selected from those of formula (I):
wherein:
represents single or double bond,
R1 represents hydrogen, alkyl, —R6-aryl, —R6-cycloalkyl, —R6-heterocycle, —CO2R7—, —COR8, or —CONHR8, wherein R6, R7, and R8 are as defined in the description,
R2 represents cyano, mono- or di-alkylaminoalkylaminocarbonyl, —CO2R8, —CONHR8, —NR8R9, —NHCO2R7, or —COR8 wherein R7, R8, and R9 are as defined in the description,
R3 and R4 together form (C3-C10)cycloalkyl,
R5 represents hydrogen, alkyl, or arylalkyl,
Ra, Rb, Rc, Rd, which may be identical or different, represent a group as defined in the description,
its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of CNS disorders.
Type:
Grant
Filed:
July 21, 2000
Date of Patent:
February 26, 2002
Assignee:
Les Laboratoires Servier
Inventors:
Solo Goldstein, Guillaume Poissonnet, Jean-Gilles Parmentier, Jean-Daniel Brion, Mark Millan, Anne Dekeyne, Jean Boutin