Patents Represented by Attorney The Genomics Institute of the Novartis Research Foundation

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  • Compounds and compositions as PPAR modulators
    Patent number: 7820705
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: October 26, 2010
    Assignee: IRM LLC
    Inventors: Robert Epple, Ross Russo, Mihai Azimioara, Yongping Xie
  • Inhibitors of cathepsin S
    Patent number: 7297714
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: November 20, 2007
    Assignee: IRM LLC
    Inventors: Hong Liu, Phillip Alper, Daniel Mutnick, Donald Karanewsky
  • Inhibitors of cathepsin S
    Patent number: 7256207
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: August 14, 2007
    Assignee: IRM LLC
    Inventors: Hong Liu, Phillip B. Alper, Donald S. Karanewsky
  • 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells
    Patent number: 7253166
    Abstract: The invention provides a novel class of compounds and compositions of Formula I: in which R1, R2 and R3 are defined herein, that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3?, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-?, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: August 7, 2007
    Assignees: IRM LLC, The Scripps Research Institute
    Inventors: Sheng Ding, Tom Wu, Nathanael S. Gray, Peter Schultz
  • Methods and compositions as protein kinase inhibitors
    Patent number: 7189729
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGF?, KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: March 13, 2007
    Assignee: IRM LLC
    Inventors: Greg Chopiuk, Pascal Furet, Nathanael Schiander Gray, Patricia Imbach, Yi Liu, Joseph Schoepfer, Ruo Steensma
  • Immunosuppressant compounds and compositions
    Patent number: 7060697
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: June 13, 2006
    Assignee: IRM LLC
    Inventors: Thomas H. Marsilje, Nathanael S. Gray, Tao Jiang, Wenshuo Lu, Shifeng Pan