Abstract: A small group of service providers, including specialists in various workplace issues, provides workplace services, such as human resource, legal, tax, accounting, environmental, financial, regulatory, governmental, technological, medical, consulting and marketing services to an organization by using a database of information concerning the organization and its contacts. An initial contact is made by a workplace resources office to the organization to gather background information on the contacts and the organization. The database is then initially populated with this background information. Later, when a situation arises that requires an answer to a specific workplace question, a contact places a telephone call to a specialist. The specialist accesses the database over a network and uses the pre-entered client-specific information to tailor advice to the specific question raised by the contact. The call and the response as categorized by the specialist are then stored in the database for later reference.

Abstract: The invention relates to a method and instrument for the fragmentation of large molecular analyte ions, preferably biopolymer ions, by reactions between multiply charged positive analyte ions and negative reactant ions in RF quadrupole ion traps. Some of these reactions involve electron transfer reactions with subsequent dissociation of the biopolymer analyte ions, and some involve the loss of a proton, leading to stable product ions. The invention can use any type of ion traps, particularly three-dimensional RF quadrupole ion traps, for the reactions between positive and negative ions. The fragmentation yield can be increased because ions that remain stable as radical cations after transfer of an electron are further fragmented by collisionally induced fragmentation, forming fragment ions that are typical of electron transfer, and not those typical of collisionally induced fragmentation.

Abstract: The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption. Always slightly distorted mass scales of different mass spectra from the same type of sample can be aligned. The flight times of identical ions always differ slightly from one mass spectrum to the next due to non-reproducible processes in the ionization method. Thus the apparent mass values of ion signals of identical substances in different mass spectra do not match even if the flight times are converted into mass values with the identical calibration equation. After alignment of the mass scales, mass spectra can be reliably compared with respect to deviations in intensities of bio-makers, or be added together without deterioration in the mass resolution, and improved reference spectrum libraries can be created. Furthermore, the invention allows more reliable library searches to be carried out.

Abstract: The invention relates to RF voltage-operated ion guides based on stacked apertured diaphragms. The invention provides ion guides consisting of diaphragm stacks that permit the ion beam to be shaped in cross-section so that it corresponds to the acceptance profile of the subsequent section of the device, therefore yielding optimal ion transmission. For this purpose, at least some of the diaphragms in the diaphragm stacks do not have circular openings, but instead have openings which shape the cross section of the emerging ion beam in the desired manner. It is possible, for instance, to obtain elliptical beam cross sections, divided beams or beams focused to the shape of a fine thread at the output of the diaphragm stacks.

Abstract: A collaboration system synchronizes an application or applications running on one or more computer systems. Each of the applications has a local data copy and the applications commence operation by creating consistent local copies from a common third copy. The consistency is maintained by distributing address space independent selections and commands to each application as they are entered at a controlling system. The selections and commands are generated by directly manipulating a presentation of each local data copy. When a selection and command arrive at a destination, the selection is used to find and selection the data and the command is applied to the data located by the selection.

Abstract: A multiple wavelength X-ray source includes an electron-generating cathode and an anode with multiple target regions, each of which emits X-rays at a different characteristic wavelength in response to the electrons. The different X-ray radiation outputs are focused by different focusing sections of a focusing optic. The multiple focusing sections are in different respective locations, and each focuses its respective X-ray radiation onto a sample. The focusing sections may be side-by-side mirrors in a Kirkpatrick-Baez configuration, or in a single-bounce, doubly curved elliptical configuration.

Abstract: The invention relates to methods and devices for measuring daughter ion spectra (also called fragment ion spectra or MS/MS spectra) in time-of-flight mass spectrometers with orthogonal injection of the ions. The invention filters the parent ions selected to be fragmented by a mass filter before they are injected into the time-of-flight mass spectrometer, fragments the selected ions in a first stage of the time-of-flight mass spectrometer within a collision cell filled with collision gas at collision energies between one and five kiloelectron-volts, further accelerates the fragment ions and measures the fragment ions in a second stage of the time-of-flight mass spectrometer.

Abstract: At a publisher location, multiple encrypted documents are assembled into a distribution archive that is also encrypted. The distribution archive is then downloaded into a content server at an unsecure site. When the content server receives the distribution archive, it decrypts the archive file and unpacks the encrypted documents, which are then stored, in encrypted form, in a local document database. When a user logs into the local content server, a secure content viewer is downloaded to the user's browser. The content viewer requests a selected document from the local server, which then forwards the encrypted document to the viewer. The viewer then computes a document identifier from the encrypted document content and requests a key from the server with the identifier. The server then returns the requested key and the viewer decrypts that document and presents it in a display area controlled by the viewer.

Abstract: The invention relates to the cleaning of contaminated accelerating or guiding electrodes of ion sources used for ion generation by desorption. A cleaning plate is used that has an outer contour similar to that of a standard sample support plate, and may be equipped with cleaning scrubbers that can be moved out when necessary to contact the electrodes. The scrubbers may include soft covers, and can carry out the cleaning by dry rubbing or with the help of high-boiling solvents for the matrix substances. The moving out of the cleaning scrubbers can be controlled by external light pulses from a laser or video camera spot light. Alternatively, the cleaning plate may be equipped with spray nozzles connected to a reservoir of cleaning fluid which is sprayed onto the electrodes, and the evacuation of the ventilated ion source chamber may be used to initiate the spraying.

Abstract: A magnetic resonance RF coil comprises a conductive material deposited on a dielectric substrate. The conductive material includes magnetic field generating elements used to generate an RF magnetic field and interdigital capacitor elements. The capacitor elements are oriented parallel to the magnetic field generating elements and, therefore, to a main static magnetic field within which the coil is to be located. This orientation minimizes arcing resulted from emitted electrons and helps to prevent catastrophic breakdown of the coil.

Abstract: A method and apparatus for partitioning network data services among multiple subscribers uses information stored in several tables to define a plurality of independent networks where each independent network comprises a set of access ports and a unique set of destination addresses and is logically separate from all other independent networks so that no information can pass from one independent network to another independent network. When a subscriber makes a request to use an independent network, a subscriber key that is based on the subscriber identity and the network access port is used to determine whether the subscriber has permission to use the independent network. If the subscriber has permission to use the independent network, information retrieved from the tables is used to determine whether the source subscriber or a destination subscriber has control over the resource.

Abstract: The invention relates to the identification of substance ions, which are usually generated by electro spray ionization after separation by liquid chromatography or capillary electrophoresis, with the help of libraries with mass spectra. The substance ions are frequently formed not only in a protonated (or deprotonated) form but also as adducts with cations or anions, a fact which complicates identification. The invention involves making identification more accurate by additionally carrying out a determination of the most probable molar mass with the help of adduct patterns.

Abstract: A sample analysis system makes use of both X-ray diffraction analysis and Raman spectroscopy of a sample. The sample is part of a sample library that is mounted on an XYZ stage that allows each sample to be examined in turn, as the XYZ stage is moved to position successive samples to a sample location. The system components may be mounted on a goniometer to allow their repositioning. A video system may be used for optical examination of the sample, and a knife edge may be used to prevent X-ray radiation from reaching a sample adjacent to the sample positioned at the sample location. A controller may be used to automatically control the operation of the analysis components and the movement of the sample holder to as to allow automated analysis of all of the samples in the sample holder.

Abstract: A method for applying a sample film to a sample carrier for subsequent spectroscopic analysis is described, comprising providing a quantity of sample in liquid state, providing a sample carrier having at least one sample position, applying the quantity of sample in liquid state on the at least one sample position in a plurality of partial quantities of the quantity of sample in such a manner that the partial quantities on the at least one sample position are not in contact with one another before being dried, drying the quantity of sample to form the sample film.

Abstract: A limited-use browser and related security system control access to content stored on a server computer linked to a network. The security system secures the content on the server and only permits it to be downloaded to a client computer running the limited-user browser or a general purpose browser executing an add-in security module providing the same functions as the limited-user browser. The limited-use browser or module secures the downloaded content on the client computer and displays it in a “view-only” mode. While the secured content is being displayed, menu selections, key combination, or pointing device commands initiated on the client computer that would modify the content or create a copy on another medium are either disabled as a default or monitored to determine if the action is permitted.

Abstract: The invention relates to an ion guide consisting of RF multipole segments to transfer ions from an ion source into a mass analyzer. The invention consists in having movable RF multipole segments in the ion guide which extend or electrically connect other RF multipole segments along the axis of the ion guide, in which spaces have arisen as a result of a change in configuration of the mass spectrometer, comprising ion source, ion guide and mass analyzer. The moved RF multipole segments bridge the spaces which have arisen between the components of the mass spectrometer and facilitate the transfer of the ions from the ion source to the mass analyzer.

Abstract: The invention relates to the ionization of analyte molecules on a solid surface close to atmospheric pressure as an ion source for mass spectrometers. The invention uses a spray mist from an electrospray apparatus to ionize the analyte molecules, for example a spray mist created by spraying pure water, which generates predominantly multiply charged ions of the analyte molecules which are particularly suitable for fragmentation.

Abstract: The invention relates to ion storage devices for a molecular detector which determines the presence and quantity of a predetermined ion species out of a large number of stored ions. The invention consists in installing two or more ion storage devices in such a way that filling of one ion storage device and detection of predetermined ion species from an other ion storage device can be carried synchronously. In particular, ion filling and ion sampling can occur through the same opening.

Abstract: A scanning line detector according to the present invention uses a detector with a linear arrangement of detection elements that is moved along a range of diffracted x-ray directions to collect data across a multidimensional detection area. The scanning line detector allows for the simulation of a two-dimensional detector system without the need for a two-dimensional detector. The detector may follow a desired path to simulate a desired shape, such as a cylinder. A slit may be included to limit the detector line width, and a scatter shield may be used to minimize noise from air-scattered x-rays. The detector may also use a specially designed monochromator for conditioning the diffracted x-rays. The detector may be rotatable about an axis parallel to a direction along which x-rays are diffracted, allowing it to be used in different orientations.