Patents Represented by Attorney, Agent or Law Firm Theodore R. West
  • Compounds and methods for modulating cerebral amyloid angiopathy
    Patent number: 6670399
    Abstract: The invention provides methods of inhibiting cerebral amyloid angiopathy. The invention further provides methods of treating a disease state characterized by cerebral amyloid angiopathy in a subject with an A&bgr;40 inhibitor having the structure: Q-[—SO3−X+]n or Q-[—OSO3−X+]n wherein Q is a carrier group; X+ is a cationic group; and n is one.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: December 30, 2003
    Assignee: Neurochem (International) Limited
    Inventors: Allan M. Green, Francine Gervais
  • Phosphono-carboxylate compounds for treating amyloidosis
    Patent number: 6440952
    Abstract: Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: August 27, 2002
    Assignee: Queen's University at Kingston
    Inventors: Walter A. Szarek, Xianqi Kong, Gregory R. J. Thatcher, Boris Gorine