Abstract: Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.
Type:
Grant
Filed:
May 23, 2000
Date of Patent:
May 13, 2003
Assignee:
Queen's University of Kingston
Inventors:
Walter A. Szarek, Donald F. Weaver, Xianqi Kong, Ajay Gupta, David Migneault