Patents Represented by Attorney, Agent or Law Firm Thomas C. Basso
  • Preparation of submicron sized nanoparticles via dispersion lyophilization
    Patent number: 6835396
    Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: December 28, 2004
    Assignee: Baxter International Inc.
    Inventors: Sean Brynjelsen, Mark Doty, James E. Kipp, Nailesh Jayswal, Krishnaswamy Narayanan