Patents Represented by Attorney Thomas E. Arthur

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  • 10,11-Dihydro-10,10 ,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-methylisocyanate compounds
    Patent number: 4070387
    Abstract: Tetrafluoro derivatives of 10,11-dihydrodibenzo[a,d]cyclohepten-5-aminomethyl compounds and the corresponding N-substituted derivatives thereof, useful as antiarrhythmic agents, are prepared from tetrafluoro derivatives of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one by reduction to the corresponding 5-ol compound and subsequently converting said 5-ol compound to the corresponding 5-halo and the 5-aminomethyl derivatives by reactions known in the prior art.
    Type: Grant
    Filed: October 4, 1976
    Date of Patent: January 24, 1978
    Assignee: Merck & Co., Inc.
    Inventor: Marcia Elizabeth Christy
  • .alpha.,.alpha.-Dialkyl-4-phenethyl-benzylamines and the salts thereof
    Patent number: 4017543
    Abstract: This application discloses methods of preparing .alpha.,.alpha.-diloweralkyl substituted benzylamines by the catalytic hydrogenation of the corresponding .alpha.,.alpha.-dialkyl-4-(phenyl-ethynyl)-benzylamine. The produced .alpha.,.alpha.-diloweralkylamines are converted to the corresponding N-alkyl and N,N-dialkyl derivatives thereof. The amines and their alkylated derivatives are useful as antiarrhythmics.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: April 12, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Marcia Elizabeth Christy
  • Precursors for prostaglandin E.sub.1
    Patent number: 3933901
    Abstract: This case relates to the synthesis of novel precursors of prostaglandin E.sub.1, particularly the intermediate 4-hydroxy-3 .alpha.-methyl-1.alpha., 2.alpha.-dilower-alkanoyloxymethylcyclohexene.
    Type: Grant
    Filed: May 2, 1973
    Date of Patent: January 20, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Zbigniew S. Zelawski, Norman L. Wendler