Patents Represented by Attorney Thomas E. Byrne

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  • Subtilisin analogs
    Patent number: 4914031
    Abstract: A class of subtilisin analogs suitable for admixture to cleaning compositions and having improved stability over naturally occurring Bacillus subtilisins are prepared by expressing a modified gene encoding the subtilisin analog in Bacillus subtilis. The subtilisin analogs are characterized as having a modified calcium binding site to improve calcium binding and either an Asn or a Gly replaced in any Asn-Gly sequences present in the subtilisin.
    Type: Grant
    Filed: April 10, 1987
    Date of Patent: April 3, 1990
    Assignee: Amgen, Inc.
    Inventors: Mark M. Zukowski, Yitzhak Stabinsky, Michael Levitt