Patents Represented by Attorney Thomas G. Plant
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Patent number: 6111067Abstract: A82846-related glycopeptide compounds are prepared by treating an antibiotic selected from A82846 components A, B and C with trifluoroacetic acid to remove 1) the .alpha.-L-O-4-epi-vancosaminyl group attached to the disaccharide; 2) the (.alpha.-L-O-4-epi-vancosaminyl-.beta.-O-glucosyl) disaccharide group or 3) both the disaccharide group and the .alpha.-L-O-4-epi-vancosaminyl group attached to the peptide core from these antibiotics. The compounds have antibacterial activity, especially against Gram-positive microorganisms.Type: GrantFiled: December 21, 1993Date of Patent: August 29, 2000Assignee: Eli Lilly and CompanyInventors: Manuel Debono, R. Michael Molloy, Ramakrishnan Nagarajan, Amelia A. Schabel
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Patent number: 5876991Abstract: A DNA molecule isolated from Streptomyces fradiae encodes the multi-functional proteins which direct the synthesis of the polyketide tylactone.Type: GrantFiled: February 21, 1997Date of Patent: March 2, 1999Assignee: Eli Lilly and CompanyInventors: Bradley S. DeHoff, Stuart A. Kuhstoss, Paul R. Rosteck, Jr., Kimberly L. Sutton
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Patent number: 5840684Abstract: The present invention provides glycopeptide antibiotic derivative compounds. These derivative compounds possess antibacterial activity against a wide variety of bacteria, including activity against vancomycin-resistant isolates. Methods of making and using these glycopeptide antibiotic derivative compounds are also provided.Type: GrantFiled: March 24, 1995Date of Patent: November 24, 1998Assignee: Eli Lilly and CompanyInventors: Robin D. G. Cooper, Bret E. Huff, Thalia I. Nicas, John T. Quatroche, Michael J. Rodriguez, Nancy J. Snyder, Michael A. Staszak, Richard C. Thompson, Stephen C. Wilkie, Mark J. Zweifel
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Patent number: 5824510Abstract: Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide transporter and in immunoassays to identify agents taken up into the cell by the human influx peptide transporter mechanism. The monoclonal antibodies are also useful for the detection and treatment of carcinomas derived from the gastrointestinal tract and pancreatic duct.Type: GrantFiled: December 1, 1994Date of Patent: October 20, 1998Assignee: Eli Lilly and CompanyInventors: Stuart W. Bright, Anne H. Dantzig, Linda B. Tabas, J. Richard Sportsman
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Patent number: 5773214Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus flavus. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus flavus MDR-1 are also provided. The invention further provides assays which utilize these transformed host cells.Type: GrantFiled: February 27, 1995Date of Patent: June 30, 1998Assignee: Eli Lilly and CompanyInventors: Robert B. Peery, Paul L. Skatrud
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Patent number: 5710018Abstract: The present invention provides isolated DNA compounds and recombinant DNA vectors that encode mammalian influx peptide transporter activity. The invention also provides host cells transformed with these vectors and a method for production of mammalian influx peptide transporter activity by recombinant DNA techniques. The invention also provides a method for identifying compounds that are transported into the cell by the influx peptide transporter.Type: GrantFiled: June 5, 1995Date of Patent: January 20, 1998Assignee: Eli Lilly and CompanyInventors: Anne H. Dantzig, Jo Ann Hoskins, Paul L. Skatrud
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Patent number: 5705352Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus fumigatus. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus fumigatus MDR-1 are also provided. The invention further provides assays which utilize these transformed host cells.Type: GrantFiled: February 27, 1995Date of Patent: January 6, 1998Assignee: Eli Lilly and CompanyInventors: Robert B. Peery, Paul L. Skatrud
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Patent number: 5700933Abstract: The present invention is directed to azetidinone compounds of the following formula: ##STR1## which are useful as intermediates to carbacephalosporins: ##STR2## These carbacephalosporins are useful as antibacterials.Type: GrantFiled: May 18, 1995Date of Patent: December 23, 1997Assignee: Eli Lilly and CompanyInventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
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Patent number: 5672700Abstract: The invention is directed to the crystalline isopropyl alcohol solvate of loracarbef, and also is directed to a process for the preparation of the crystalline monohydrate form of the compound of formula (I) ##STR1## which includes exposing the crystalline isopropyl solvate form of the compound of formula (I) to a temperature of between about 50.degree. and 90.degree. C. and a relative humidity of between about 60 to about 100%.Type: GrantFiled: December 1, 1994Date of Patent: September 30, 1997Assignee: Eli Lilly and CompanyInventors: William C. Henning, Michael E. O'Dea
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Patent number: 5658788Abstract: The present invention provides derivatives of tissue plasminogen activator that lack the Finger, Growth Factor and Kringle 1 domains and comprise a Kringle 2 domain that is monoglycosylated at a site other than that of t-PA. Using recombinant DNA techniques, an alternate glycosylation sequence is provided within the Kringle 2 domain of these t-PA derivatives. This alternate glycosylation consensus sequence, as well as the glycosylation consensus sequence within the Serine Protease domain, is glycosylated upon the expression and secretion of these molecules from eucaryotic host cells. Thus, a homogeneous population of diglycosylated t-PA derivatives that lack the Finger, Growth Factor and Kringle 1 domains is produced.Type: GrantFiled: April 21, 1995Date of Patent: August 19, 1997Assignee: Eli Lilly and CompanyInventors: David T. Berg, Brian W. Grinnell
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Patent number: 5644051Abstract: This invention is directed to carbacephems and methods for their preparation: ##STR1## In the foregoing formulae, R.sup.3 represents phenyl, C.sub.1 -C.sub.4 alkylphenyl, halophenyl, C.sub.1 -C.sub.4 alkoxyphenyl, naphthyl, thienyl, furyl, benzothienyl, or benzofuryl.Type: GrantFiled: May 18, 1995Date of Patent: July 1, 1997Assignee: Eli Lilly and CompanyInventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
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Patent number: 5620855Abstract: The present invention provides isolated DNA compounds and recombinant DNA vectors that encode mammalian influx peptide transporter activity. The invention also provides host cells transformed with these vectors and a method for production of mammalian influx peptide transporter activity by recombinant DNA techniques. The invention also provides a method for identifying compounds that are transported into the cell by the influx peptide transporter.Type: GrantFiled: May 1, 1995Date of Patent: April 15, 1997Assignee: Eli Lilly and CompanyInventors: Anne H. Dantzig, Jo A. Hoskins, Paul L. Skatrud
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Patent number: 5578720Abstract: This invention provides for crystalline hydrochloride C.sub.1 -C.sub.3 alcohol solvate forms of the compound of formula (I): ##STR1## In particular, crystalline hydrochloride ethanol, methanol, and propanol solvates are disclosed.Type: GrantFiled: May 18, 1995Date of Patent: November 26, 1996Assignee: Eli Lilly and CompanyInventors: Jane G. Amos, Perry C. Heath, Douglas E. Prather, John E. Toth
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Patent number: 5576190Abstract: The present invention concerns novel DNA compounds which function as transcriptional activating sequences. Recombinant DNA expression vectors which contain the transcriptional activating sequences and host cells transformed with these expression vectors are also provided. When properly positioned in an expression vector, the novel transcriptional activating sequences enable regulatable expression of an operably linked gene and enhance the structural stability of the expression vector.Type: GrantFiled: November 23, 1993Date of Patent: November 19, 1996Assignee: Eli Lilly and CompanyInventors: Rama M. Belagaje, Charles L. Hershberger, Hansen M. Hsiung, Paul R. Rosteck, Jr., Jane L. Sterner
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Patent number: 5573936Abstract: Echinocandin B deacylase is purified to near homogeneity from Actinoplanes utahensis by a process comprising, in order, extracting the soluble enzyme, heating to 60.degree. C., hydrophobic interaction chromatography, (NH.sub.4).sub.2 SO.sub.4 fractionation, gel filtration, cation exchange chromatography, dye-ligand chromatography, gel filtration, and cation-exchange chromatography.Type: GrantFiled: May 18, 1995Date of Patent: November 12, 1996Assignee: Eli Lilly and CompanyInventors: Adam J. Kreuzman, Wu-Kuang Yeh
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Patent number: 5534420Abstract: New glycopeptides prepared by biotransformation of a vancomycin-type antibiotic by an Acinomadura citrea culture (NRRL 18382), which are useful intermediates, and methods of preparing the biotransformed intermediates by adding a vancomycin-type glycopeptide to a growing culture of Actinomadura citrea NRRL 18382 and continuing fermentation under submerged aerobic conditions, are provided.Type: GrantFiled: May 18, 1995Date of Patent: July 9, 1996Assignee: Eli Lilly and CompanyInventors: Manuel Debono, Robert M. Logan, Gary G. Marconi, R. Michael Molloy, Milton J. Zmijewski, Jr.
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Patent number: 5521307Abstract: A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.Type: GrantFiled: February 18, 1992Date of Patent: May 28, 1996Assignee: Eli Lilly and CompanyInventors: Jack W. Fisher, Lowell D. Hatfield, Richard C. Hoying, James E. Ray
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Patent number: 5516655Abstract: The invention provides isolated nucleic acid compounds encoding the multiple drug resistance protein of Aureobasidium pullulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aureobasidium pullulans are also provided. The invention further provides assays which utilize these transformed host cells.Type: GrantFiled: April 20, 1994Date of Patent: May 14, 1996Assignee: Eli Lilly and CompanyInventors: Robert B. Peery, Paul L. Skatrud
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Patent number: 5508177Abstract: The present invention provides processes for isolating in substantially purified form water-soluble penicillin binding protein 2a of Staphylococcus aureus.Type: GrantFiled: May 14, 1993Date of Patent: April 16, 1996Assignee: Eli Lilly and CompanyInventors: Joe E. Dotzlaf, Sandhya K. Ghag, Wu-Kuang Yeh
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Patent number: 5500346Abstract: Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide transporter and in immunoassays to identify agents taken up into the cell by the human influx peptide transporter mechanism. The monoclonal antibodies are also useful for the detection and treatment of carcinomas derived from the gastrointestinal tract and pancreatic duct.Type: GrantFiled: June 29, 1993Date of Patent: March 19, 1996Assignee: Eli Lilly and CompanyInventors: Stuart W. Bright, Anne H. Dantzig, Linda B. Tabas, J. Richard Sportsman